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Artificial Cells, Blood Substitutes, and Biotechnology Volume 22, 1994 - Issue 3
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Original Article

Genetic Engineering of Myoglobin as a Simple Prototype for Hemoglobin-Based Blood Substitutes

J. S. Olson Department of Biochemistry and Cell Biology and the W. M. Keck Center for Computational Biology, Rice University, Houston, Texas, 77251–1892
Pages 429-441 | Published online: 11 Jul 2009

Citations (12)

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John S. Olson, Raymund F. Eich, Lucian P. Smith, Joshua J. Warren & Brian C. Knowles. (1997) Protein Engineering Strategies for Designing More Stable Hemoglobin-based Blood Substitutes. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 227-241.
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Articles from other publishers (11)

Shruti Mathur, Sanjeev Kumar Yadav, Kajal Yadav, Shruti Bhatt & Suman Kundu. (2023) A novel single sensor hemoglobin domain from the thermophilic cyanobacteria Thermosynechococcus elongatus BP-1 exhibits higher pH but lower thermal stability compared to globins from mesophilic organisms. International Journal of Biological Macromolecules 240, pages 124471.
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Sheetal Uppal, Mohd. Asim Khan & Suman Kundu. (2021) Stability and Folding of the Unusually Stable Hemoglobin from Synechocystis is Subtly Optimized and Dependent on the Key Heme Pocket Residues. Protein & Peptide Letters 28:2, pages 164-182.
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Clara Fronticelli & Raymond C. Koehler. (2009) Design of Recombinant Hemoglobins for Use in Transfusion Fluids. Critical Care Clinics 25:2, pages 357-371.
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Philip E. Graves, Douglas P. Henderson, Molly J. Horstman, Brian J. Solomon & John S. Olson. (2008) Enhancing stability and expression of recombinant human hemoglobin in E. coli: Progress in the development of a recombinant HBOC source. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1784:10, pages 1471-1479.
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John S. Olson, Erin W. Foley, Corina Rogge, Ah-Lim Tsai, Michael P. Doyle & Douglas D. Lemon. (2004) No scavenging and the hypertensive effect of hemoglobin-based blood substitutes. Free Radical Biology and Medicine 36:6, pages 685-697.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Abdu I. Alayash, Rakesh P. Patel & Robert E. Cashon. (2001) Redox Reactions of Hemoglobin and Myoglobin: Biological and Toxicological Implications. Antioxidants & Redox Signaling 3:2, pages 313-327.
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Felice D’Agnillo & Abdu I. Alayash. (2000) Site-specific modifications and toxicity of blood substitutes. Advanced Drug Delivery Reviews 40:3, pages 199-212.
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A.I. Alayash. 1998. Blood Substitutes, Present and Future Perspectives. Blood Substitutes, Present and Future Perspectives 201 210 .
Abdu I. Alayash & Robert E. Cashon. (1995) Hemoglobin and free radicals: implications for the development of a safe blood substitute. Molecular Medicine Today 1:3, pages 122-127.
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Melanie S. Rogers, Beth Brockner Ryan, Robert E. Cashon & Abdu I. Alayash. (1995) Effects of polymerization on the oxygen carrying and redox properties of diaspirin cross-linked hemoglobin. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1248:2, pages 135-142.
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