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Original Article

Initial Clinical Experience with a Rationally Designed, Genetically Engineered Recombinant Human Hemoglobin

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Pages 457-465 | Published online: 11 Jul 2009

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Read on this site (7)

Qi Zhang, Yue-Xiang Ma, Zheng Dai, Bin Zhang, Shan-Shou Liu, Wen-Xiu Li, Chuan-Qing Fu, Qian-Mei Wang & Wen Yin. (2023) Tracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review. Drug Design, Development and Therapy 17, pages 2549-2571.
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Xian-Zhong Li, Qin-Hong Yang, Jiu-Feng Yan, Ke Xu, Jia Liu, Xue-Ying He, Xiao-Wei Zhang & Qian Liu. (2007) Characterization of Poly(ethylene glycol)-modified Bovine Hemoglobin By Capillary Zone Electrophoresis. Artificial Cells, Blood Substitutes, and Biotechnology 35:1, pages 1-10.
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Xianzhong Li, Xiaowei Zhang & Qian Liu. (2005) Determination of the Molecular Weight Distribution of the PEGylated Bovine Hemoglobin (PEG-bHb). Artificial Cells, Blood Substitutes, and Biotechnology 33:1, pages 13-25.
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Thomas Ming Swi Chang. (1997) Recent and Future Developments in Modified Hemoglobin and Microencapsulated Hemoglobin as Red Blood Cell Substitutes. Artificial Cells, Blood Substitutes, and Biotechnology 25:1-2, pages 1-24.
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. (1996) Editorial. Artificial Cells, Blood Substitutes, and Biotechnology 24:4, pages ix-xxiv.
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Kwok L. Shum, Albert León, Anna T. Viau, Denis Pilon, Mary Nucci & Robert G. L. Shorr. (1996) The Physiological and Histopathological Response of Dogs to Exchange Transfusion with Polyethylene Glycol-Modified Bovine Hemoglobin (PEG-Hb). Artificial Cells, Blood Substitutes, and Biotechnology 24:6, pages 655-683.
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Thomas F. Zuck, Jean G. Riess & G. P. Biro. (1994) Current Status of Injectable Oxygen Carriers. Critical Reviews in Clinical Laboratory Sciences 31:4, pages 295-324.
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Articles from other publishers (16)

Thomas Ming Swi Chang. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 99 115 .
Michelle Simons, Svetlana Gretton, Gary G.A. Silkstone, Badri S. Rajagopal, Victoria Allen-Baume, Natalie Syrett, Thoufieq Shaik, Nelida Leiva-Eriksson, Luca Ronda, Andrea Mozzarelli, Michael B. StraderAbdu I. AlayashBrandon J. Reeder & Chris E. Cooper. (2018) Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers. Bioscience Reports 38:4.
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Thomas Ming Swi Chang. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 3 26 .
Stefano Bettati & Andrea Mozzarelli. 2011. Chemistry and Biochemistry of Oxygen Therapeutics. Chemistry and Biochemistry of Oxygen Therapeutics 9 22 .
G. Deby-Dupont, Bernadette Remy & Maurice Lamy. 2010. Alternatives to Blood Transfusion in Transfusion Medicine. Alternatives to Blood Transfusion in Transfusion Medicine 368 379 .
M.ª Soledad Asuero & Trinidad Dorado. 2010. Tratado de Medicina Transfusional Perioperatoria. Tratado de Medicina Transfusional Perioperatoria 327 339 .
Y. Smani, P. Labrude, C. Vigneron & B. Faivre. (2007) Les transporteurs d’oxygène à base d’hémoglobine et les tentatives de substituer les globules rouges. Transfusion Clinique et Biologique 14:5, pages 464-473.
Crossref
Sarit Sivan & Noah Lotan. 2006. Wiley Encyclopedia of Biomedical Engineering. Wiley Encyclopedia of Biomedical Engineering.
Robert Larbuisson, Ginette Deby‐Dupont & Maurice Lamy. (2008) Oxygen Carriers in Cardiac Surgery. Transfusion Alternatives in Transfusion Medicine 7:1, pages 42-57.
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Monique Marchand-Arvier, Alexis Caron & Claude Vigneron. (2001) Les transporteurs d'oxygène à base d'hémoglobine. Revue Française des Laboratoires 2001:331, pages 61-62.
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B. Rémy, G. Deby-Dupont, V. D'Ans, P. Ernest & M. Lamy. (1999) Substituts des globules rouges: émulsions de fluorocarbures et solutions d'hémoglobine. Annales Françaises d'Anesthésie et de Réanimation 18:2, pages 211-224.
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T.M.S. Chang. 1998. Biotechnolgy Annual Review. Biotechnolgy Annual Review 75 112 .
Steven H Zuckerman, Glenn F Evans & Nancy Bryan. (1997) Interactions of recombinant hemoglobin (rHb 1.1) and endotoxin in vivo: Effects on systemic tumor necrosis factor and interleukin-6 levels in lethal and sublethal murine models of endotoxemia. Journal of Laboratory and Clinical Medicine 130:4, pages 427-435.
Crossref
David A. Fowler, Gary J. Rosenthal & Jean-Pierre Sommadossi. (1996) Effect of recombinant human hemoglobin on human bone marrow progenitor cells: protection and reversal of 3′ -azido-3′ -deoxythymidine-induced toxicity. Toxicology Letters 85:1, pages 55-62.
Crossref
Stephen B. OlsenDouglas B. TangMark R. JacksonEdward R. GomezBenjamin AyalaBarbara M. Alving. (1996) Enhancement of Platelet Deposition by Cross-Linked Hemoglobin in a Rat Carotid Endarterectomy Model. Circulation 93:2, pages 327-332.
Crossref
Aaron J. MarcusM. Johan Broekman. (1996) Cell-Free Hemoglobin as an Oxygen Carrier Removes Nitric Oxide, Resulting in Defective Thromboregulation. Circulation 93:2, pages 208-209.
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