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Artificial Cells, Blood Substitutes, and Biotechnology Volume 22, 1994 - Issue 3
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Original Article

Diaspirin Crosslinked Hemoglobin (DCLHbTM): Characterization of the Process and the Product Manufactured Under GMP Requirements for Clinical Studies

M. Azari Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073
,
K. Rohn Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073
&
J. Picken Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073
Pages 701-708 | Published online: 11 Jul 2009

Citations (14)

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Read on this site (2)

M. Azari, A. Ebeling, R Baker, K. Burhop, T. Camacho, T. Estep, S. Guzder, T. Marshall, K. Rohn, R Sarajari, J. A. Boose, G. Gauvin, R Homer, B. Lu, L. Pearson & D. Vacante. (1998) Validation of the Heat Treatment Step Used in the Production of Diaspirln Crosslinked Hemoglobin (DCLHb™) For Viral Inactivation. Artificial Cells, Blood Substitutes, and Biotechnology 26:5-6, pages 577-582.
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M. Azari, J. Catarello, K. Burhop, T. Camacho, A. Ebeling, T. Estep, S. Guzder, K. Krause, T. Marshall, K. Rohn, R. Sarajari, J. A. Boose, G. Gauvin, R. Horner, B. Lu, L. Pearson & D. Vacante. (1997) Validation of the Heat Treatment Step Used in the Production of Diaspirin Crosslinked Hemoglobin (Delhb™) For Viral Deactivation - Effect of Crosslinking. Artificial Cells, Blood Substitutes, and Biotechnology 25:6, pages 521-526.
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Articles from other publishers (12)

Timothy N. Estep. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 287 292 .
Michael Brad StraderAbdu I. Alayash. (2017) Exploring Oxidative Reactions in Hemoglobin Variants Using Mass Spectrometry: Lessons for Engineering Oxidatively Stable Oxygen Therapeutics. Antioxidants & Redox Signaling 26:14, pages 777-793.
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Deanna J. Nelson. 2006. Blood Substitutes. Blood Substitutes 399 414 .
Robert M. Winslow. 2006. Blood Substitutes. Blood Substitutes 386 398 .
Paul W. Buehler & Abdu I. Alayash. (2004) Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion 44:10, pages 1516-1530.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Andreas W. Sielenkämper, Pei Yu, Otto Eichelbrönner, Tammy MacDonald, Claudio M. Martin, Ian H. Chin-Yee & William J. Sibbald. (2000) Diaspirin cross-linked Hb and norepinephrine prevent the sepsis-induced increase in critical O 2 delivery . American Journal of Physiology-Heart and Circulatory Physiology 279:4, pages H1922-H1930.
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Robert M. Winslow. (2000) alphaalpha-Crosslinked Hemoglobin: Was Failure Predicted by Preclinical Testing?. Vox Sanguinis 79:1, pages 1-20.
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Andreas W. Sielenkämper, Otto Eichelbrönner, Claudio M. Martin, Sean W. Madorin, Ian H. Chin-Yee & William J. Sibbald. (2000) Diaspirin cross-linked hemoglobin improves mucosal perfusion in the ileum of septic rats. Critical Care Medicine 28:3, pages 782-787.
Crossref
Robert J. Przybelski, Elaine K. Daily, Jean Micheels, Edward Sloan, Pierre Mols, Luc Corne, Max D. Koenigsberg, William H. Bickell, Dan R. Thompson, Jay D. Harviel & Stephen M. Cohn. (2012) A Safety Assessment of Diaspirin Cross-Linked Hemoglobin (DCLHb) in the Treatment of Hemorrhagic, Hypovolemic Shock. Prehospital and Disaster Medicine 14:4, pages 47-60.
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Ritu SaxenaAnnemarie D. WijnhoudHerwig CartonWerner HackeMarkku KasteRobert J. PrzybelskiKathleen N. SternPeter J. Koudstaal. (1999) Controlled Safety Study of a Hemoglobin-Based Oxygen Carrier, DCLHb, in Acute Ischemic Stroke. Stroke 30:5, pages 993-996.
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Ritu Saxena, Annemarie D. Wijnhoud, Arie J. Man ʼt Veld, Anton H. van den Meiracker, Frans Boomsma, Robert J. Przybelski & Peter J. Koudstaal. (1998) Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man. Journal of Hypertension 16:10, pages 1459-1465.
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