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Artificial Cells, Blood Substitutes, and Biotechnology Volume 22, 1994 - Issue 4
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Original Article

Influence of Perflubron Emulsion Particle Size on Blood Half-Life and Febrile Response in Rats

P. E. Keipert Alliance Pharmaceutical Corp., San Diego, CA, 92121
,
S. Otto Alliance Pharmaceutical Corp., San Diego, CA, 92121
,
S. F. Flaim Alliance Pharmaceutical Corp., San Diego, CA, 92121
,
J. G. Weers Alliance Pharmaceutical Corp., San Diego, CA, 92121
,
E. A. Schutt Alliance Pharmaceutical Corp., San Diego, CA, 92121
,
T. J. Pelura Alliance Pharmaceutical Corp., San Diego, CA, 92121
,
D. H. Klein Alliance Pharmaceutical Corp., San Diego, CA, 92121
&
T. L. Yaksh Dept. of Anesthesiology, University of California, San Diego, CA, 92093
 show all
Pages 1169-1174 | Published online: 11 Jul 2009

Citations (52)

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Xiao Li, Zhongguo Sui, Xin Li, Wen Xu, Qie Guo, Jialin Sun & Fanbo Jing. (2018) Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery. International Journal of Nanomedicine 13, pages 3053-3067.
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Anna Wrobeln, Klaus D. Schlüter, Jürgen Linders, Manfred Zähres, Christian Mayer, Michael Kirsch & Katja B. Ferenz. (2017) Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart . Artificial Cells, Nanomedicine, and Biotechnology 45:4, pages 723-730.
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Wassana Yeeprae, Shigeru Kawakami, Yuriko Higuchi, Fumiyoshi Yamashita & Mitsuru Hashida. (2005) Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice. Journal of Drug Targeting 13:8-9, pages 479-487.
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Brian Lyons, Joel P. R. Balkaran, Darcy Dunn-Lawless, Veronica Lucian, Sara B. Keller, Colm S. O’Reilly, Luna Hu, Jeffrey Rubasingham, Malavika Nair, Robert Carlisle, Eleanor Stride, Michael Gray & Constantin Coussios. (2023) Sonosensitive Cavitation Nuclei—A Customisable Platform Technology for Enhanced Therapeutic Delivery. Molecules 28:23, pages 7733.
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Jialiang Zhang, Qiang Feng, Jianbin Xiao, Jinyu Zhang, Jiao Lin & Jianmin Wang. (2023) Microneedle-assisted transdermal delivery of perfluorotripropylamine-based oxygenated emulsion gel loaded with 5-aminolevulinic acid for enhanced photodynamic therapy of cutaneous squamous cell carcinoma. European Journal of Pharmaceutical Sciences 188, pages 106493.
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Charlotte Bérard, Stéphane Desgranges, Noé Dumas, Anthony Novell, Benoit Larrat, Mourad Hamimed, Nicolas Taulier, Marie-Anne Estève, Florian Correard & Christiane Contino-Pépin. (2022) Perfluorocarbon Nanodroplets as Potential Nanocarriers for Brain Delivery Assisted by Focused Ultrasound-Mediated Blood–Brain Barrier Disruption. Pharmaceutics 14:7, pages 1498.
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Peter E. Keipert. 2022. Blood Substitutes and Oxygen Biotherapeutics. Blood Substitutes and Oxygen Biotherapeutics 325 334 .
Ryan Bardsley, Graeme Gardner, Hubert M. Tse & Christopher A. Fraker. (2021) Optical sensor arrays designed for guided manufacture of perfluorocarbon nanoemulsions with a non-synthetic stabilizer. Acta Biomaterialia 136, pages 558-569.
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Ian Vargas, Daniel J. Stephenson, Margaret Baldwin, Joseph P. Gaut, Charles E. Chalfant, Hua Pan & Samuel A. Wickline. (2021) Sustained local inhibition of thrombin preserves renal microarchitecture and function after onset of acute kidney injury. Nanomedicine: Nanotechnology, Biology and Medicine 38, pages 102449.
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Catalina-Paula Spatarelu, Austin Van Namen & Geoffrey P. Luke. (2021) Optically Activatable Double-Drug-Loaded Perfluorocarbon Nanodroplets for On-Demand Image-Guided Drug Delivery. ACS Applied Nano Materials 4:8, pages 8026-8038.
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Mae Jemison & Ronke Olabisi. (2021) Biomaterials for human space exploration: A review of their untapped potential. Acta Biomaterialia 128, pages 77-99.
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Johannes Jägers, Anna Wrobeln & Katja B. Ferenz. (2020) Perfluorocarbon-based oxygen carriers: from physics to physiology. Pflügers Archiv - European Journal of Physiology 473:2, pages 139-150.
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Tamilvanan ShunmugaperumalOly Katari, Tamilvanan Shunmugaperumal, Datta Maroti Pawde & Abhinab Goswami. 2020. Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting. Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting 287 368 .
Dirk Mayer & Katja Bettina Ferenz. (2019) Perfluorocarbons for the treatment of decompression illness: how to bridge the gap between theory and practice. European Journal of Applied Physiology 119:11-12, pages 2421-2433.
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Eric Lambert, Vijay S Gorantla & Jelena M Janjic. (2019) Pharmaceutical design and development of perfluorocarbon nanocolloids for oxygen delivery in regenerative medicine. Nanomedicine 14:20, pages 2697-2712.
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Bruce D. Spiess. (2019) Perfluorocarbon Gas Transport: an Overview of Medical History With Yet Unrealized Potentials. Shock 52:1S, pages 7-12.
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Ina Vernikouskaya, Alexander Pochert, Mika Lindén & Volker Rasche. (2018) Quantitative 19F MRI of perfluoro-15-crown-5-ether using uniformity correction of the spin excitation and signal reception. Magnetic Resonance Materials in Physics, Biology and Medicine 32:1, pages 25-36.
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Behrouz Ashrafi, Mohammad Hossein Tootoonchi, Ryan Bardsley, Ruth Damaris Molano, Phillip Ruiz, Ernesto A. PrettoJr.Jr. & Christopher A. Fraker. (2018) Stable perfluorocarbon emulsions for the delivery of halogenated ether anesthetics. Colloids and Surfaces B: Biointerfaces 172, pages 797-805.
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Bruce D. Spiess. 2018. Hematologic Challenges in the Critically Ill. Hematologic Challenges in the Critically Ill 363 389 .
Christine Arthur, Lin Song, William Culp, Aliza Brown, Michael Borrelli, Robert Skinner & Howard Hendrickson. (2016) Tissue Concentration of Dodecafluoropentane (DDFP) Following Repeated IV Administration in the New Zealand White Rabbit. The AAPS Journal 19:2, pages 520-526.
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N. Giuliani, M. Saugy, M. Augsburger & V. Varlet. (2015) Blood monitoring of perfluorocarbon compounds (F-tert-butylcyclohexane, perfluoromethyldecalin and perfluorodecalin) by headspace-gas chromatography-tandem mass spectrometry. Talanta 144, pages 196-203.
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Pan Kee Bae & Bong Hyun Chung. (2014) Multiplexed detection of various breast cancer cells by perfluorocarbon/quantum dot nanoemulsions conjugated with antibodies. Nano Convergence 1:1.
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Jia-Hui Liu, Sheng-Tao Yang, Xin Wang, Haifang Wang, Yamin Liu, Pengju G. Luo, Yuanfang Liu & Ya-Ping Sun. (2014) Carbon Nanoparticles Trapped in Vivo—Similar to Carbon Nanotubes in Time-Dependent Biodistribution. ACS Applied Materials & Interfaces 6:16, pages 14672-14678.
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Junjie Chen, Hua Pan, Gregory M. Lanza & Samuel A. Wickline. (2013) Perfluorocarbon Nanoparticles for Physiological and Molecular Imaging and Therapy. Advances in Chronic Kidney Disease 20:6, pages 466-478.
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Pan Kee Bae, Juyeon Jung, Su Jin Lim, Daehong Kim, Seok-Ki Kim & Bong Hyun Chung. (2013) Bimodal Perfluorocarbon Nanoemulsions for Nasopharyngeal Carcinoma Targeting. Molecular Imaging and Biology 15:4, pages 401-410.
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Céline Giraudeau, Boucif Djemaï, Mohamed Ahmed Ghaly, Fawzi Boumezbeur, Sébastien Mériaux, Philippe Robert, Marc Port, Caroline Robic, Denis Le Bihan, Franck Lethimonnier & Julien Valette. (2012) High sensitivity 19F MRI of a perfluorooctyl bromide emulsion: application to a dynamic biodistribution study and oxygen tension mapping in the mouse liver and spleen. NMR in Biomedicine 25:4, pages 654-660.
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Sun-Joo Lee, Paul H. Schlesinger, Samuel A. Wickline, Gregory M. Lanza & Nathan A. Baker. (2012) Simulation of fusion-mediated nanoemulsion interactions with model lipid bilayers. Soft Matter 8:26, pages 7024.
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Junjie Chen, Gregory M. Lanza & Samuel A. Wickline. (2010) Quantitative magnetic resonance fluorine imaging: today and tomorrow. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2:4, pages 431-440.
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Donald J. AbrahamStefano Bruno, Luca Ronda, Serena Faggiano, Stefano Bettati & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 609 660 .
Megan M. Kaneda, Shelton Caruthers, Gregory M. Lanza & Samuel A. Wickline. (2009) Perfluorocarbon Nanoemulsions for Quantitative Molecular Imaging and Targeted Therapeutics. Annals of Biomedical Engineering 37:10, pages 1922-1933.
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Shelton D. CaruthersTillmann CyrusPatrick M. WinterSamuel A. WicklineGregory M. Lanza. (2009) Anti‐angiogenic perfluorocarbon nanoparticles for diagnosis and treatment of atherosclerosis. WIREs Nanomedicine and Nanobiotechnology 1:3, pages 311-323.
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Valérie Centis & Patrick Vermette. (2008) Physico-chemical properties and cytotoxicity assessment of PEG-modified liposomes containing human hemoglobin. Colloids and Surfaces B: Biointerfaces 65:2, pages 239-246.
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Marla R. Wolfson, Daniel J. Malone, Jichuan Wu, John Hoffman, Allan Rozenberg, Thomas H. Shaffer & Denise Barbut. (2008) Intranasal Perfluorochemical Spray for Preferential Brain Cooling in Sheep. Neurocritical Care 8:3, pages 437-447.
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Shelton D. Caruthers, Anne M. Neubauer, Frank D. Hockett, Rolf Lamerichs, Patrick M. Winter, Michael J. Scott, Patrick J. Gaffney, Samuel A. Wickline & Gregory M. Lanza. (2006) In Vitro Demonstration Using 19F Magnetic Resonance to Augment Molecular Imaging With Paramagnetic Perfluorocarbon Nanoparticles at 1.5 Tesla. Investigative Radiology 41:3, pages 305-312.
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Peter E. Keipert. 2006. Blood Substitutes. Blood Substitutes 312 323 .
Hae Won Kim & A. Gerson Greenburg. (2004) Artificial Oxygen Carriers as Red Blood Cell Substitutes: A Selected Review and Current Status. Artificial Organs 28:9, pages 813-828.
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Jeffry G. Weers, Rebecca A. Arlauskas, Thomas E. Tarara & Timothy J. Pelura. (2004) Characterization of Fluorocarbon-in-Water Emulsions With Added Triglyceride. Langmuir 20:18, pages 7430-7435.
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Jeffry G. Weers & Rebecca A. Arlauskas. (2004) Particle size analysis of perfluorocarbon emulsions in a complex whole blood matrix by sedimentation field-flow fractionation. Colloids and Surfaces B: Biointerfaces 33:3-4, pages 265-269.
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Donald J. AbrahamBarbara Campanini, Stefano Bruno, Samanta Raboni & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 385 441 .
ALAN R. SPITZER, JAY S. GREENSPAN, WILLIAM W. FOX & THOMAS SHAFFER. 2003. Assisted Ventilation of the Neonate. Assisted Ventilation of the Neonate 219 234 .
Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Marie-Pierre Krafft. (2001) Les émulsions de fluorocarbures (PFC) : Des transporteurs d'oxygène injectables efficaces et facilement détectables. Revue Française des Laboratoires 2001:331, pages 55-59.
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Christopher P. Stowell, Jack Levin, Bruce D. Spiess & Robert M. Winslow. (2002) Progress in the development of RBC substitutes. Transfusion 41:2, pages 287-299.
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Robert J. Noveck, E. J. Shannon, Phillip T. Leese, Jolene S. Shorr, Kathryn E. Flaim, Peter E. Keipert & Catherine M. Woods. (2000) Randomized Safety Studies of Intravenous Perflubron Emulsion. II. Effects on Immune Function in Healthy Volunteers. Anesthesia & Analgesia 91:4, pages 812-822.
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Phillip T. Leese, Robert J. Noveck, Jolene S. Shorr, Catherine M. Woods, Kathryn E. Flaim & Peter E. Keipert. (2000) Randomized Safety Studies of Intravenous Perflubron Emulsion. I. Effects on Coagulation Function in Healthy Volunteers. Anesthesia & Analgesia 91:4, pages 804-811.
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Michel Audran, Marie Pierre Krafft, Jacques De Ceaurriz, Jean-Charles Maturin, Marie-Thérèse Sicart, Bénédicte Marion, Guillaume Bougard & Françoise Bressolle. (2000) Determination of perfluorodecalin and perfluoro-N-methylcyclohexylpiperidine in rat blood by gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 745:2, pages 333-343.
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Jean G. Riess. 2000. Fluorine Chemistry at the Millennium. Fluorine Chemistry at the Millennium 385 431 .
Michel Audran, Marie-Pierre Krafft, Jacques De Ceaurriz, Jean-Charles Mathurin, Marie-Thérèse Sicart, Bénédicte Marion, Fabien Fabre & Françoise Bressolle. (1999) Assay method for the perfluorooctyl bromide (perflubron) in rat blood by gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 734:2, pages 267-276.
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G. L. Wolf. 1999. Trends in Contrast Media. Trends in Contrast Media 21 30 .
Marla R. Wolfson, Jay S. Greenspan & Thomas H. Shaffer. (1998) Liquid-assisted ventilation: An alternative respiratory modality. Pediatric Pulmonology 26:1, pages 42-63.
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Jay S. Greenspan, Gerard M. Cleary & Marla R. Wolfson. (1998) Is Liquid Ventilation a Reasonable Alternative?. Clinics in Perinatology 25:1, pages 137-157.
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Marla R. Wolfson & Thomas H. Shaffer. (1997) Liquid-assisted ventilation: From concept to clinical application. Seminars in Neonatology 2:2, pages 115-127.
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