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Original Article

A New Theory of Enterorecirculation of Amino Acids and its use for Depleting Unwanted Amino Acids Using Oral Enzyme-Artificial Cells, as in Removing Phenylalanine in Phenylketonuria

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Pages 1-21 | Published online: 11 Jul 2009

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Binglan Yu & Thomas Ming Swi Chang. (2002) IN VITRO ENZYME KINETICS OF MICROENCAPSULATED TYROSINASE. Artificial Cells, Blood Substitutes, and Biotechnology 30:5-6, pages 533-546.
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Sarah Safos. (1995) Enzyme Replacement Therapy in ENU2 Phenylketonuric Mice Using Oral Microencapsulated Phenylalanine Ammonia-Lyase: A Preliminary Report. Artificial Cells, Blood Substitutes, and Biotechnology 23:6, pages 681-692.
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Peng Gu, Li Xie, Tao Chen, Qin Yang, Xianglong Zhang, Ruofan Liu, Jiayin Guo, Rongjuan Wei, Dongping Li, Yong Jiang, Ye Chen, Wei Gong & Peng Chen. (2023) An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1. Journal of Hepatology.
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Jerry Vockley, Neal Sondheimer, Marja Puurunen, George A. Diaz, Ilona Ginevic, Dorothy K. Grange, Cary Harding, Hope Northrup, John A. PhillipsIIIIII, Shawn Searle, Janet A. Thomas, Roberto Zori, William S. Denney, Sharon L. Ernst, Kristina Humphreys, Nicole McWhorter, Caroline Kurtz & Aoife M. Brennan. (2023) Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial. Nature Metabolism 5:10, pages 1685-1690.
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Kristen Skvorak, Vesna Mitchell, Leann Teadt, Kierra A. Franklin, Hyung-Ok Lee, Nikki Kruse, Callie Huitt-Roehl, Julie Hang, Faye Du, Stephanie Galanie, Steven Guan, Hera Aijaz, Nianliu Zhang, Gabriel Rajkovic, Warren D. Kruger, Moulay Hicham Alaoui Ismaili, Gjalt Huisman, Kerryn McCluskie & Adam P. Silverman. (2023) An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract. Molecular Genetics and Metabolism 139:4, pages 107653.
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Luciana d’Amone, Vikas D. Trivedi, Nikhil U. Nair & Fiorenzo G. Omenetto. (2022) A Silk-Based Platform to Stabilize Phenylalanine Ammonia-lyase for Orally Administered Enzyme Replacement Therapy. Molecular Pharmaceutics 19:12, pages 4625-4630.
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Matthew ChangKangsan Kim, Donghui Choe, Minjeong Kang, Bong Hyun Sung, Haseong Kim, Seung‐Goo Lee, Dae‐Hee Lee & Byung‐Kwan Cho. 2022. Principles in Microbiome Engineering. Principles in Microbiome Engineering 93 119 .
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Els van der Goot, Stefanie N. Vink, Danique van Vliet, Francjan J. van Spronsen, Joana Falcao Salles & Eddy A. van der Zee. (2022) Gut-Microbiome Composition in Response to Phenylketonuria Depends on Dietary Phenylalanine in BTBR Pahenu2 Mice. Frontiers in Nutrition 8.
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Marja K. Puurunen, Jerry Vockley, Shawn L. Searle, Stephanie J. Sacharow, John A. PhillipsIIIIII, William S. Denney, Benjamin D. Goodlett, David A. Wagner, Larry Blankstein, Mary J. Castillo, Mark R. Charbonneau, Vincent M. Isabella, Vasu V. Sethuraman, Richard J. Riese, Caroline B. Kurtz & Aoife M. Brennan. (2021) Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study. Nature Metabolism 3:8, pages 1125-1132.
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Mark R. Charbonneau, William S. Denney, Nicholas G. Horvath, Pasquale Cantarella, Mary J. Castillo, Marja K. Puurunen & Aoife M. Brennan. (2021) Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria. Communications Biology 4:1.
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Francjan J. van Spronsen, Nenad Blau, Cary Harding, Alberto Burlina, Nicola Longo & Annet M. Bosch. (2021) Phenylketonuria. Nature Reviews Disease Primers 7:1.
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Irene Pereira de Sousa, Charlotte Gourmel, Olena Berkovska, Michael Burger & Jean-Christophe Leroux. (2020) A microparticulate based formulation to protect therapeutic enzymes from proteolytic digestion: phenylalanine ammonia lyase as case study. Scientific Reports 10:1.
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Vincent M Isabella, Binh N Ha, Mary Joan Castillo, David J Lubkowicz, Sarah E Rowe, Yves A Millet, Cami L Anderson, Ning Li, Adam B Fisher, Kip A West, Philippa J Reeder, Munira M Momin, Christopher G Bergeron, Sarah E Guilmain, Paul F Miller, Caroline B Kurtz & Dean Falb. (2018) Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nature Biotechnology 36:9, pages 857-864.
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Arturo López-Villalobos, Joost Lücker, Ana Angela López-Quiróz, Edward C. Yeung, Kristoffer Palma & Allison R. Kermode. (2014) Preservation of high phenylalanine ammonia lyase activities in roots of Japanese Striped corn: A potential oral therapeutic to treat phenylketonuria. Cryobiology 68:3, pages 436-445.
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Christineh N. Sarkissian, Tse Siang Kang, Alejandra Gámez, Charles R. Scriver & Raymond C. Stevens. (2011) Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of Phenylketonuria. Molecular Genetics and Metabolism 104:3, pages 249-254.
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Woo-Mi Kim. (2009) Development of Modified Phenylalanine Ammonia-lyase for the Treatment of Phenylketonuria. Biomolecules and Therapeutics 17:1, pages 104-110.
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Kiyoshi Takasuna, Chiba Katsuyoshi & Sunao Manabe. (2009) Pre-clinical QT Risk Assessment in Pharmaceutical Companies - Issues of Current QT Risk Assessment -. Biomolecules and Therapeutics 17:1, pages 1-11.
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Osvaldo Freitas, Clarice Izumi, Marilisa G. Lara & Lewis J. Greene. (2009) New Approaches to the Treatment of Phenylketonuria. Nutrition Reviews 57:3, pages 65-70.
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