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Artificial Cells, Blood Substitutes, and Biotechnology Volume 24, 1996 - Issue 6
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Original Article

Transitional Vacuole Formation Following a Bolus Infusion of Peg-Hemoglobin in the Rat

Charles Conover Research and Development Formulations-Toxicology Department, Enzon Inc., 40 Kingsbridge Rd., Piscataway, NJ, 08854
,
Laura Lejeune Research and Development Formulations-Toxicology Department, Enzon Inc., 40 Kingsbridge Rd., Piscataway, NJ, 08854
,
Rita Linberg Research and Development Formulations-Toxicology Department, Enzon Inc., 40 Kingsbridge Rd., Piscataway, NJ, 08854
,
Kwok Shum Research and Development Formulations-Toxicology Department, Enzon Inc., 40 Kingsbridge Rd., Piscataway, NJ, 08854
&
Robert G. L. Shorr Research and Development Formulations-Toxicology Department, Enzon Inc., 40 Kingsbridge Rd., Piscataway, NJ, 08854
Pages 599-611 | Published online: 11 Jul 2009

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Ruth Duncan. (2017) Polymer therapeutics at a crossroads? Finding the path for improved translation in the twenty-first century. Journal of Drug Targeting 25:9-10, pages 759-780.
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Charles Conover, Rita Linberg, Laura Lejeune, Carl Gilbert, Kwok Shum & Robert G. L. Shorr. (1998) Evaluation of the Oxygen Delivery Ability of Peghemoglobin in Sprague-Dawley Rats During Hemodilution. Artificial Cells, Blood Substitutes, and Biotechnology 26:2, pages 199-212.
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Articles from other publishers (31)

Zhipeng Zeng, Shi Chen & Yongming Chen. (2023) Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG. ChemMedChem 18:20.
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Wataru Okamoto, Tomone Usui, Mai Hasegawa, Tatsuhiro Kobayashi, Junya Fujisawa, Kazuaki Taguchi, Kazuaki Matsumoto, Mitsutomo Kohno, Masayuki Iwazaki, Shotaro Shimano, Itsuma Nagao, Hiroto Toyoda, Naoki Matsumura, Hirotaka Tomiyasu, Ryota Tochinai & Teruyuki Komatsu. (2023) Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs. Scientific Reports 13:1.
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Wei Wu, Juan Zhou, Chuandong Wu, Qian Zhou, Xiaoyu Li, Yanlin Zhang, Conglin Zuo, Jun Yin, Ling Hou, Shuyang Wang, Hongyang Gao, Tianhong Luo, Lei Jin, Enhong Zhong, Yingwu Wang & Xiaoping Luo. (2022) PEGylated Recombinant Human Growth Hormone Jintrolong® Exhibits Good Long-Term Safety in Cynomolgus Monkeys and Human Pediatric Growth Hormone Deficiency Patients. Frontiers in Endocrinology 13.
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Ankit Javia, Jigar Vanza, Denish Bardoliwala, Saikat Ghosh, Late Ambikanandan Misra, Mrunali Patel & Hetal Thakkar. (2022) Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview. International Journal of Pharmaceutics 623, pages 121863.
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Junyong Park, Mijeong Bak, Kiyoon Min, Hyun-Woo Kim, Jeong-Haeng Cho, Giyoong Tae & Inchan Kwon. (2021) Effect of C-terminus Conjugation via Different Conjugation Chemistries on In Vivo Activity of Albumin-Conjugated Recombinant GLP-1. Pharmaceutics 13:2, pages 263.
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Migyeong Jo, Sanghwan Ko, Bora Hwang, Sung‐Won Min, Ji Yeon Ha, Ji Chul Lee, Se‐Eun Jang & Sang Taek Jung. (2020) Engineered human FcγRIIa fusion: A novel strategy to extend serum half‐life of therapeutic proteins. Biotechnology and Bioengineering 117:8, pages 2351-2361.
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Filippo Moncalvo, Maria Isabel Martinez Espinoza & Francesco Cellesi. (2020) Nanosized Delivery Systems for Therapeutic Proteins: Clinically Validated Technologies and Advanced Development Strategies. Frontiers in Bioengineering and Biotechnology 8.
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Bibifatima Kaupbayeva & Alan J. Russell. (2020) Polymer-enhanced biomacromolecules. Progress in Polymer Science 101, pages 101194.
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Anthony M. Fletcher, Pierre Tellier, Julie Douville, Peter Mansell, Michael J. Graziano, Raja S. Mangipudy, Thomas A. Brodie & William E. Achanzar. (2019) Adverse vacuolation in multiple tissues in cynomolgus monkeys following repeat-dose administration of a PEGylated protein. Toxicology Letters 317, pages 120-129.
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Armando R. Irizarry Rovira, Bindu M. Bennet, Brad Bolon, Annamaria Braendli-Baiocco, Sundeep Chandra, Renaud Fleurance, Robert Garman, David Hutto, Joan Lane, Annette Romeike, Aaron Sargeant & Bevin Zimmerman. (2018) Scientific and Regulatory Policy Committee Points to Consider: Histopathologic Evaluation in Safety Assessment Studies for PEGylated Pharmaceutical Products. Toxicologic Pathology 46:6, pages 616-635.
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Jinmei Bai, Xiaoying Tang, Yuan Zhang, Jingjing Lin & Minfeng Li. (2018) Amphiphilic diblock copolymer of hydrophilic-functionalized lactone and lactide via switchable organocatalytic polymerization . RSC Advances 8:4, pages 1905-1908.
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Tacey X. Viegas, Zhihao Fang, Kunsang Yoon, Rebecca Weimer & Bekir Dizman. 2018. Engineering of Biomaterials for Drug Delivery Systems. Engineering of Biomaterials for Drug Delivery Systems 173 198 .
Thomas Forest, Qiuwei Xu, Sabu Kuruvilla, Heather Vu, Katerina Vlasakova, Warren E. Glaab, Cathy Hines & Song Xun. (2017) Magnetic Resonance and Ultrastructural Characterization of PEGylation-associated Vacuolation in Nonclinical Models. Toxicologic Pathology 45:5, pages 604-613.
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R. Stidl, S. Fuchs, M. Bossard, J. Siekmann, P. L. Turecek & M. Putz. (2015) Safety of PEGylated recombinant human full‐length coagulation factor VIII (BAX 855) in the overall context of PEG and PEG conjugates. Haemophilia 22:1, pages 54-64.
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Yizhi Qi & Ashutosh Chilkoti. (2015) Protein–polymer conjugation — moving beyond PEGylation. Current Opinion in Chemical Biology 28, pages 181-193.
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Zhijian He, Lei Miao, Rainer Jordan, Devika S-Manickam, Robert Luxenhofer & Alexander V. Kabanov. (2015) A Low Protein Binding Cationic Poly(2-oxazoline) as Non-Viral Vector. Macromolecular Bioscience 15:7, pages 1004-1020.
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Emma M. Pelegri-O’Day, En-Wei Lin & Heather D. Maynard. (2014) Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation. Journal of the American Chemical Society 136:41, pages 14323-14332.
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Andreas Baumann, Dietrich Tuerck, Saileta Prabhu, Leslie Dickmann & Jennifer Sims. (2014) Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?. Drug Discovery Today 19:10, pages 1623-1631.
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Athina Anastasaki, Alice J. Haddleton, Qiang Zhang, Alexandre Simula, Martijn Droesbeke, Paul Wilson & David M. Haddleton. (2014) Aqueous Copper-Mediated Living Radical Polymerisation of N -Acryloylmorpholine, SET-LRP in Water . Macromolecular Rapid Communications 35:10, pages 965-970.
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Gianfranco Pasut. (2014) Polymers for Protein Conjugation. Polymers 6:1, pages 160-178.
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Chengzao Sun, James L. Trevaskis, Carolyn M. Jodka, Swetha Neravetla, Pete Griffin, Kui Xu, Yan Wang, David G. Parkes, Bruce Forood & Soumitra S. Ghosh. (2013) Bifunctional PEGylated Exenatide-Amylinomimetic Hybrids to Treat Metabolic Disorders: An Example of Long-Acting Dual Hormonal Therapeutics. Journal of Medicinal Chemistry 56:22, pages 9328-9341.
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Gianfranco Pasut & Francesco M. Veronese. (2012) State of the art in PEGylation: The great versatility achieved after forty years of research. Journal of Controlled Release 161:2, pages 461-472.
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Anna Mero, Zhihao Fang, Gianfranco Pasut, Francesco M. Veronese & Tacey X. Viegas. (2012) Selective conjugation of poly(2-ethyl 2-oxazoline) to granulocyte colony stimulating factor. Journal of Controlled Release 159:3, pages 353-361.
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Tacey X. Viegas, Michael D. Bentley, J. Milton Harris, Zhihao Fang, Kunsang Yoon, Bekir Dizman, Rebecca Weimer, Anna Mero, Gianfranco Pasut & Francesco M. Veronese. (2011) Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery. Bioconjugate Chemistry 22:5, pages 976-986.
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Hiromi Sakai, Yasushi Seishi, Yosuke Obata, Shinji Takeoka, Hirohisa Horinouichi, Eishun Tsuchida & Koichi Kobayashi. (2009) FLUID RESUSCITATION WITH ARTIFICIAL OXYGEN CARRIERS IN HEMORRHAGED RATS. Shock 31:2, pages 192-200.
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Rob Webster, Victoria Elliott, B. Kevin Park, Donald Walker, Mark Hankin & Philip Taupin. 2009. PEGylated Protein Drugs: Basic Science and Clinical Applications. PEGylated Protein Drugs: Basic Science and Clinical Applications 127 146 .
Tacey X. Viegas & Francesco M. Veronese. 2009. PEGylated Protein Drugs: Basic Science and Clinical Applications. PEGylated Protein Drugs: Basic Science and Clinical Applications 273 281 .
C.Simone Fishburn. (2008) The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics. Journal of Pharmaceutical Sciences 97:10, pages 4167-4183.
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KIM D. VANDEGRIFF, MARK A. YOUNG, PETER E. KEIPERT & ROBERT M. WINSLOW. (2007) The safety profile of Hemospan ® : a new oxygen therapeutic designed using maleimide poly(ethylene) glycol conjugation to human hemoglobin . Transfusion Alternatives in Transfusion Medicine 9:4, pages 213-225.
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Mark A. Young, Ashok Malavalli, Nancy Winslow, Kim D. Vandegriff & Robert M. Winslow. (2007) Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. Translational Research 149:6, pages 333-342.
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Donald J. AbrahamBarbara Campanini, Stefano Bruno, Samanta Raboni & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 385 441 .

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