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Artificial Cells, Blood Substitutes, and Biotechnology Volume 25, 1997 - Issue 6
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Original Article

Validation of the Heat Treatment Step Used in the Production of Diaspirin Crosslinked Hemoglobin (Delhb™) For Viral Deactivation - Effect of Crosslinking

M. Azari Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USAView further author information
,
J. Catarello Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
K. Burhop Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
T. Camacho Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
A. Ebeling Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
T. Estep Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
S. Guzder Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
K. Krause Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
T. Marshall Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
,
K. Rohn Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
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R. Sarajari Blood Substitutes Program, Baxter Healthcare Corporation, Round Lake, Illinois, 60073, USA
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J. A. Boose Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
,
G. Gauvin Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
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R. Horner Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
,
B. Lu Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
,
L. Pearson Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
&
D. Vacante Process Validation Division, Microbiological Associates, Inc., Rockville, Maryland, 20850, USA
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Pages 521-526 | Published online: 04 Aug 2009

Citations (6)

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Sandra M. Erhart, Daniel J. Cole, Piyush M. Patel, John C. Drummond & Kenneth E. Burhop. (2000) Effect of α-α Diaspirin Crosslinked Hemoglobin (DCLHbTM) on the Potency of Sodium Nitroprusside and Nitroglycerine to Decrease Blood Pressure in Rats: A Dose-Response Study. Artificial Cells, Blood Substitutes, and Biotechnology 28:5, pages 385-396.
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Articles from other publishers (5)

Yuju Kim & Ronald Kluger. (2022) Efficient formation of hemoglobin bis-tetramers via selective acetylation of α-subunit amino groups by methyl acetyl phosphate . Organic & Biomolecular Chemistry 20:41, pages 8083-8091.
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Kenneth W. Olsen & Eugene Tarasov. 2011. Chemistry and Biochemistry of Oxygen Therapeutics. Chemistry and Biochemistry of Oxygen Therapeutics 327 344 .
Pierre Sonveaux, Irina I. Lobysheva, Olivier Feron & Timothy J. McMahon. (2007) Transport and Peripheral Bioactivities of Nitrogen Oxides Carried by Red Blood Cell Hemoglobin: Role in Oxygen Delivery. Physiology 22:2, pages 97-112.
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Jean G. Riess. (2001) Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some Physiology Blut ist ein ganz besondrer Saft . Chemical Reviews 101:9, pages 2797-2920.
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Robert M. Winslow. (2000) alphaalpha-Crosslinked Hemoglobin: Was Failure Predicted by Preclinical Testing?. Vox Sanguinis 79:1, pages 1-20.
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