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Original Article

Kinetic Studies of Hepatocyte Udp-Glucuronosyltransferase: Evidence of An Allosteric Enzyme

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Pages 343-356 | Published online: 11 Jul 2009

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Michael B. Fisher, Mary F. Paine, Timothy J. Strelevitz & Steven A. Wrighton. (2001) The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism*†. Drug Metabolism Reviews 33:3-4, pages 273-297.
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Articles from other publishers (14)

Jamie M. Hooft, Yanping Lou, E. James Squires, John P. Cant & Dominique P. Bureau. (2021) Development of a microplate method for the determination of hepatic UDP-glucuronosyltransferase activity in rainbow trout (Oncorhynchus mykiss) and Nile tilapia (Oreochromis niloticus). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 248, pages 109114.
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Nagendra Sai Kumar Achanta, Kuldeep Rajpoot & Rakesh Kumar Tekade. 2021. Biopharmaceutics and Pharmacokinetics Considerations. Biopharmaceutics and Pharmacokinetics Considerations 335 353 .
Hui Peng, Tianbao Yang, Bruce D. Whitaker, Lingfei Shangguan & Jinggui Fang. (2016) Calcium/calmodulin alleviates substrate inhibition in a strawberry UDP-glucosyltransferase involved in fruit anthocyanin biosynthesis. BMC Plant Biology 16:1.
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Alexander V. LyubimovRobert S. Foti, Dan A. Rock, Larry C. Wienkers & Jan L. Wahlstrom. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 68 .
Alexander V. LyubimovRobert S. Foti & Michael B. Fisher. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 71 .
KAMAHLDIN HAGHBEEN, MASOUMEH BABAEI KHALILI, FATMEH SAEID NEMATPOUR, NEMATOLAH GHEIBI, MOSTAFA FAZLI, MEHDI ALIJANIANZADEH, SAMANEH ZOLGHADRI JAHROMI & REYHANEH SARIRI. (2010) SURVEYING ALLOSTERIC COOPERATIVITY AND COOPERATIVE INHIBITION IN MUSHROOM TYROSINASE. Journal of Food Biochemistry 34:2, pages 308-328.
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QING WANG, CINDY YE, RICHARD JIA, ALBERT J. OWEN, ISMAEL J. HIDALGO & JIBIN LI. (2006) INTER-SPECIES COMPARISON OF 7-HYDROXYCOUMARIN GLUCURONIDATION AND SULFATION IN LIVER S9 FRACTIONS. In Vitro Cellular & Developmental Biology - Animal 42:1, pages 8.
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Qing Wang, Cindy YE, Richard Jia, Albert J. Owen, Ismael J. Hidalgo & Jibin Li. (2006) Inter-species comparison of 7-hydroxycoumarin glucuronidation and sulfation in liver S9 fractions. In Vitro Cellular & Developmental Biology - Animal 42:1-2, pages 8-12.
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Paraskevi Tsoutsikos, John O Miners, Alan Stapleton, Anthony Thomas, Benedetta C Sallustio & Kathleen M Knights. (2004) Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7. Biochemical Pharmacology 67:1, pages 191-199.
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Matthew G. Soars, Barbara J. Ring & Steven A. Wrighton. (2003) THE EFFECT OF INCUBATION CONDITIONS ON THE ENZYME KINETICS OF UDP-GLUCURONOSYLTRANSFERASES. Drug Metabolism and Disposition 31:6, pages 762-767.
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J. Andrew Williams, Barbara J. Ring, Varon E. Cantrell, Kristina Campanale, David R. Jones, Stephen D. Hall & Steven A. Wrighton. (2002) Differential Modulation of UDP-Glucuronosyltransferase 1A1 (UGT1A1)-Catalyzed Estradiol-3-glucuronidation by the Addition of UGT1A1 Substrates and Other Compounds to Human Liver Microsomes. Drug Metabolism and Disposition 30:11, pages 1266-1273.
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Lance B. Augustin & Clifford J. Steer. 2002. Encyclopedia of Molecular Biology. Encyclopedia of Molecular Biology.
Lance B. Augustin & Clifford J. Steer. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
J. Matthew Hutzler & Timothy S. Tracy. (2002) Atypical Kinetic Profiles in Drug Metabolism Reactions. Drug Metabolism and Disposition 30:4, pages 355-362.
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