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Journal of Receptors and Signal Transduction Volume 20, 2000 - Issue 1
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Research Article

Functional Receptor Coupling to Gi Is A Mechanism of Agonist-Promoted Desensitization of the β2-Adrenergic Receptor

Nicole M. Tepe Department of Pharmacology, Medicine University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH, 45267-0564
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Stephen B. Liggett Department of Pharmacology, Medicine University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH, 45267-0564
Pages 75-85 | Published online: 26 Sep 2008

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Mihai-Sergiu Jalba. (2008) Three Generations of Ongoing Controversies Concerning the Use of Short Acting Beta-Agonist Therapy in Asthma: A Review. Journal of Asthma 45:1, pages 9-18.
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Articles from other publishers (20)

Wayne C. H. WangSusan H. PauerDan'elle C. SmithMadison A. DixonDavid J. DisimileAlfredo PanebraSteven S. An, Blanca Camoretti-MercadoStephen B. Liggett. (2014) Targeted transgenesis identifies G αs as the bottleneck in β 2 -adrenergic receptor cell signaling and physiological function in airway smooth muscle . American Journal of Physiology-Lung Cellular and Molecular Physiology 307:10, pages L775-L780.
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William E. Schutzer & Scott L. Mader. (2012) Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly. International Journal of Hypertension 2012, pages 1-10.
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Khalid Chakir, Weizhong Zhu, Sharon Tsang, Anthony Yiu-Ho Woo, Dongmei Yang, Xianhua Wang, Xiaokun Zeng, Man-Hee Rhee, Ulrike Mende, Norimichi Koitabashi, Eiki Takimoto, Kendall J. Blumer, Edward G. Lakatta, David A. Kass & Rui-Ping Xiao. (2011) RGS2 is a primary terminator of β2-adrenergic receptor-mediated Gi signaling. Journal of Molecular and Cellular Cardiology 50:6, pages 1000-1007.
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Wayne C. H. Wang, Rachel M. Schillinger, Molly M. Malone & Stephen B. Liggett. (2011) Paradoxical attenuation of β 2 -AR function in airway smooth muscle by G i -mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase . American Journal of Physiology-Lung Cellular and Molecular Physiology 300:3, pages L472-L478.
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Tongguang Wang, Myoung-Hwa Lee, Tory Johnson, Rameeza Allie, Lina Hu, Peter A. Calabresi & Avindra Nath. (2010) Activated T-Cells Inhibit Neurogenesis by Releasing Granzyme B: Rescue by Kv1.3 Blockers. The Journal of Neuroscience 30:14, pages 5020-5027.
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Anne-Marie LompréRoger J. HajjarSian E. HardingEvangelia G. KraniasMartin J. LohseAndrew R. Marks. (2010) Ca 2+ Cycling and New Therapeutic Approaches for Heart Failure . Circulation 121:6, pages 822-830.
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Ruijie Liu, Biswarathan Ramani, Dagoberto Soto, Vania De Arcangelis & Yang Xiang. (2009) Agonist Dose-dependent Phosphorylation by Protein Kinase A and G Protein-coupled Receptor Kinase Regulates β2 Adrenoceptor Coupling to Gi Proteins in Cardiomyocytes. Journal of Biological Chemistry 284:47, pages 32279-32287.
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Syeda M. Kabir, Shyamali Mukherjee, Veera Rajaratnam, Milton G. Smith & Salil K. Das. (2009) Desensitization of β-adrenergic receptors in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. Journal of Biochemical and Molecular Toxicology 23:1, pages 59-70.
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Gökhan M. Mutlu & Phillip Factor. (2008) Alveolar Epithelial β 2 -Adrenergic Receptors . American Journal of Respiratory Cell and Molecular Biology 38:2, pages 127-134.
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Steven M. Swift, Mary Rose Schwarb, Kathryn A. Mihlbachler & Stephen B. Liggett. (2007) Pleiotropic β-Agonist–Promoted Receptor Conformations and Signals Independent of Intrinsic Activity. American Journal of Respiratory Cell and Molecular Biology 36:2, pages 236-243.
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Andrea Barbuti, Benedetta Terragni, Chiara Brioschi & Dario DiFrancesco. (2007) Localization of f-channels to caveolae mediates specific β2-adrenergic receptor modulation of rate in sinoatrial myocytes. Journal of Molecular and Cellular Cardiology 42:1, pages 71-78.
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W. E. Schutzer, H. Xue, J. F. Reed & S. L. Mader. (2006) Effect of Age on Vascular ss2-Adrenergic Receptor Desensitization Is Not Mediated by the Receptor Coupling to G i Proteins. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61:9, pages 899-906.
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Tongguang Wang, Rameeza Allie, Katherine Conant, Norman Haughey, Jadwiga Turchan-Cholewo, Katrin Hahn, Antony Rosen, Joseph Steiner, Sanjay Keswani, Melina Jones, Peter A. Calabresi, Avindra Nath, Tongguang Wang, Rameeza Allie, Katherine Conant, Norman Haughey, Jadwiga Turchan-Cholewo, Katrin Hahn, Antony Rosen, Joseph Steiner, Sanjay Keswani, Melina Jones, Peter A. Calabresi & Avindra Nath. (2006) Granzyme B mediates neurotoxicity through a G‐protein‐coupled receptor. The FASEB Journal 20:8, pages 1209-1211.
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Irene H. Heijink, Edo Vellenga, Jaap Oostendorp, Jan G. R. de Monchy, Dirkje S. Postma & Henk F. Kauffman. (2005) Exposure to TARC alters β 2 -adrenergic receptor signaling in human peripheral blood T lymphocytes . American Journal of Physiology-Lung Cellular and Molecular Physiology 289:1, pages L53-L59.
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I. H. Heijink, M. van den Berge, E. Vellenga, J. G. R. de Monchy, D. S. Postma & H. F. Kauffman. (2004) Altered beta2-adrenergic regulation of T cell activity after allergen challenge in asthma. Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy 34:9, pages 1356-1363.
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Carole Frances, Pierre Nazeyrollas, Alain Prevost, Françoise Moreau, Jean Pisani, Siamak Davani, Jean-Pierre Kantelip & Hervé Millart. (2003) Role of β1- and β2-Adrenoceptor Subtypes in Preconditioning Against Myocardial Dysfunction after Ischemia and Reperfusion. Journal of Cardiovascular Pharmacology 41:3, pages 396-405.
Crossref
Stephen B. Liggett. (2002) Update on current concepts of the molecular basis of β2-adrenergic receptor signaling. Journal of Allergy and Clinical Immunology 110:6, pages S223-S228.
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Asma H. Baig, Francesca M. Swords, Luke A. Noon, Peter J. King, László Hunyady & Adrian J.L. Clark. (2001) Desensitization of the Y1 Cell Adrenocorticotropin Receptor. Journal of Biological Chemistry 276:48, pages 44792-44797.
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Stephen B. Liggett. (2001) β-Adrenergic receptors in the failing heart: the good, the bad, and the unknown. Journal of Clinical Investigation 107:8, pages 947-948.
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Connie M. Drysdale, Dennis W. McGraw, Catharine B. Stack, J. Claiborne Stephens, Richard S. Judson, Krishnan Nandabalan, Kevin Arnold, Gualberto Ruano & Stephen B. Liggett. (2000) Complex promoter and coding region β 2 -adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness . Proceedings of the National Academy of Sciences 97:19, pages 10483-10488.
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