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Research Article

The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic β-cells

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Pages 293-298 | Received 09 Jul 2009, Accepted 30 Jul 2009, Published online: 23 Nov 2009

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Xiang Li, Hong Qin, Ali Anwar, Xingwen Zhang, Fang Yu, Zheng Tan & Zhanhong Tang. (2022) Molecular mechanism analysis of m6A modification-related lncRNA-miRNA-mRNA network in regulating autophagy in acute pancreatitis. Islets 14:1, pages 184-199.
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Beata Pyrzynska, Michal Dwojak, Abdessamad Zerrouqi, Giulia Morlino, Piotr Zapala, Nina Miazek, Agnieszka Zagozdzon, Kamil Bojarczuk, Malgorzata Bobrowicz, Marta Siernicka, Marcin M. Machnicki, Stefania Gobessi, Joanna Barankiewicz, Ewa Lech-Maranda, Dimitar G. Efremov, Przemyslaw Juszczynski, Dinis Calado, Jakub Golab & Magdalena Winiarska. (2018) FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy. OncoImmunology 7:5.
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Yinghui Qiu, Xiaoxiang Gao, Ruoxin Chen, Suyue Lu, Xuzhi Wan, Mohamed A. Farag & Chao Zhao. (2022) Metabolomics and biochemical insights on the regulation of aging-related diabetes by a low-molecular-weight polysaccharide from green microalga Chlorella pyrenoidosa. Food Chemistry: X 14, pages 100316.
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Yuezhen Ouyang, Dan Liu, Lizhu Zhang, Xiaoqing Li, Xinhua Chen & Chao Zhao. (2021) Green Alga Enteromorpha prolifera Oligosaccharide Ameliorates Ageing and Hyperglycemia through Gut–Brain Axis in Age‐Matched Diabetic Mice . Molecular Nutrition & Food Research 66:4, pages 2100564.
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Jeng Yie Chan, Mohammed Bensellam, Ruby C. Y. Lin, Cassandra Liang, Kailun Lee, Jean‐Christophe Jonas & D. Ross Laybutt. (2021) Transcriptome analysis of islets from diabetes‐resistant and diabetes‐prone obese mice reveals novel gene regulatory networks involved in beta‐cell compensation and failure. The FASEB Journal 35:6.
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Hilary A. Coller. (2019) The paradox of metabolism in quiescent stem cells. FEBS Letters 593:20, pages 2817-2839.
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Li-dan Zhao, Di Liang, Xiang-ni Wu, Yang Li, Jing-wen Niu, Chen Zhou, Li Wang, Hua Chen, Wen-jie Zheng, Yun-yun Fei, Fu-lin Tang, Yong-zhe Li, Feng-chun Zhang, Wei He, Xue-tao Cao & Xuan Zhang. (2016) Contribution and underlying mechanisms of CXCR4 overexpression in patients with systemic lupus erythematosus. Cellular & Molecular Immunology 14:10, pages 842-849.
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Wei-Lin Qiu, Yu-Wei Zhang, Ye Feng, Lin-Chen Li, Liu Yang & Cheng-Ran Xu. (2017) Deciphering Pancreatic Islet β Cell and α Cell Maturation Pathways and Characteristic Features at the Single-Cell Level. Cell Metabolism 25:5, pages 1194-1205.e4.
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Markus M. Xie, Tohti Amet, Hong Liu, Qigui Yu & Alexander L. Dent. (2017) AMP kinase promotes Bcl6 expression in both mouse and human T cells. Molecular Immunology 81, pages 67-75.
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QI ZENG, XIAOAN TAO, FANG HUANG, TONG WU, JUAN WANG, XIAO JIANG, ZIRONG KUANG & BIN CHENG. (2016) Overexpression of miR-155 promotes the proliferation and invasion of oral squamous carcinoma cells by regulating BCL6/cyclin D2. International Journal of Molecular Medicine 37:5, pages 1274-1280.
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Anup Shrestha, Saroj Nepal, Mi Jin Kim, Jae Hoon Chang, Sang-Hyun Kim, Gil-Saeng Jeong, Chul-Ho Jeong, Gyu Hwan Park, Sunghee Jung, Jaecheong Lim, Eunha Cho, Soyoung Lee & Pil-Hoon Park. (2016) Critical Role of AMPK/FoxO3A Axis in Globular Adiponectin-Induced Cell Cycle Arrest and Apoptosis in Cancer Cells. Journal of Cellular Physiology 231:2, pages 357-369.
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Hongxiao Jiao, Kai Wang, Fuhua Yang, Struan F. A. Grant, Hakon Hakonarson, R. Arlen Price & Wei-Dong Li. (2015) Pathway-Based Genome-Wide Association Studies for Plasma Triglycerides in Obese Females and Normal-Weight Controls. PLOS ONE 10:8, pages e0134923.
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Yoon Sin Oh. (2015) Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids. Anatomy & Cell Biology 48:1, pages 16.
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Yun Sun Park, Jeong-Woo Kang, Dong Hun Lee, Man Sub Kim, Yesol Bak, Young Yang, Hee Gu Lee, JinTae Hong & Do-Young Yoon. (2014) Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification. Oncotarget 5:18, pages 8765-8777.
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Grace Lin, Christopher R. LaPensee, Zhaohui S. Qin & Jessica Schwartz. (2014) Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3. Molecular and Cellular Endocrinology 395:1-2, pages 19-31.
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Jeffrey D. Coleman, Jerry T. Thompson, Russell W. Smith, Bogdan Prokopczyk & John P. Vanden Heuvel. (2013) Role of Peroxisome Proliferator-Activated Receptor and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells . PPAR Research 2013, pages 1-11.
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Stephen M. Hedrick, Rodrigo Hess Michelini, Andrew L. Doedens, Ananda W. Goldrath & Erica L. Stone. (2012) FOXO transcription factors throughout T cell biology. Nature Reviews Immunology 12:9, pages 649-661.
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Mariana Igoillo-Esteve, Esteban N. Gurzov, Décio L. Eizirik & Miriam Cnop. (2011) The Transcription Factor B-Cell Lymphoma (BCL)-6 Modulates Pancreatic β-Cell Inflammatory Responses. Endocrinology 152:2, pages 447-456.
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Lye T. Lock, Suzanne G. Laychock & Emmanuel S. Tzanakakis. (2011) Pseudoislets in stirred-suspension culture exhibit enhanced cell survival, propagation and insulin secretion. Journal of Biotechnology 151:3, pages 278-286.
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Marisa R. Buchakjian & Sally Kornbluth. (2010) The engine driving the ship: metabolic steering of cell proliferation and death. Nature Reviews Molecular Cell Biology 11:10, pages 715-727.
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