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Research Articles

On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers

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Pages 287-303 | Received 08 Feb 2010, Accepted 18 Feb 2010, Published online: 30 Apr 2010

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Diego Guidolin, Luigi F Agnati, Manuela Marcoli, Dasiel O Borroto-Escuela & Kjell Fuxe. (2015) G-protein-coupled receptor type A heteromers as an emerging therapeutic target. Expert Opinion on Therapeutic Targets 19:2, pages 265-283.
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Luigi Francesco Agnati, Diego Guidolin, Giuseppina Leo, Michele Guescini, Marina Pizzi, Vilberto Stocchi, Pier Francesco Spano, Roberta Ghidoni, Francisco Ciruela, Susanna Genedani & Kjell Fuxe. (2011) Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. Journal of Receptors and Signal Transduction 31:5, pages 315-331.
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Articles from other publishers (22)

Chiara Cervetto, Guido Maura, Diego Guidolin, Sarah Amato, Cristina Ceccoli, Luigi F. Agnati & Manuela Marcoli. (2023) Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders. Neuropharmacology 237, pages 109636.
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Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Chiara Cervetto, Guido Maura & Luigi F. Agnati. (2023) Receptor-receptor interactions and microvesicle exchange as mechanisms modulating signaling between neurons and astrocytes. Neuropharmacology 231, pages 109509.
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Luigi F. Agnati, Diego Guidolin, Chiara Cervetto, Guido Maura & Manuela Marcoli. (2023) Brain Structure and Function: Insights from Chemical Neuroanatomy. Life 13:4, pages 940.
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Manuela Marcoli, Luigi F. Agnati, Rafael Franco, Pietro Cortelli, Deanna Anderlini, Diego Guidolin, Chiara Cervetto & Guido Maura. (2023) Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases. Frontiers in Endocrinology 13.
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Ana B. Caniceiro, Beatriz Bueschbell, Anke C. Schiedel & Irina S. Moreira. (2022) Class A and C GPCR Dimers in Neurodegenerative Diseases. Current Neuropharmacology 20:11, pages 2081-2141.
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Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Guido Maura & Luigi F. Agnati. (2022) Intercellular Communication in the Central Nervous System as Deduced by Chemical Neuroanatomy and Quantitative Analysis of Images: Impact on Neuropharmacology. International Journal of Molecular Sciences 23:10, pages 5805.
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Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Chiara Cervetto, Guido Maura & Luigi F. Agnati. (2021) Receptor–Receptor Interactions and Glial Cell Functions with a Special Focus on G Protein-Coupled Receptors. International Journal of Molecular Sciences 22:16, pages 8656.
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Kavya Prasad, Erik F. J. de Vries, Philip H. Elsinga, Rudi A. J. O. Dierckx & Aren van Waarde. (2021) Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging. International Journal of Molecular Sciences 22:4, pages 1719.
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Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. 2020. Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors. Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors 247 277 .
Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. (2019) Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?. Frontiers in Endocrinology 10.
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Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. (2018) G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication. Reviews in the Neurosciences 29:7, pages 703-726.
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Luigi F. Agnati, Manuela Marcoli, Guido Maura, Amina Woods & Diego Guidolin. (2018) The brain as a “hyper-network”: the key role of neural networks as main producers of the integrated brain actions especially via the “broadcasted” neuroconnectomics. Journal of Neural Transmission 125:6, pages 883-897.
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Batoul Farran. (2017) An update on the physiological and therapeutic relevance of GPCR oligomers. Pharmacological Research 117, pages 303-327.
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Diego Guidolin, Manuela Marcoli, Guido Maura & Luigi F. Agnati. (2017) New dimensions of connectomics and network plasticity in the central nervous system. Reviews in the Neurosciences 28:2, pages 113-132.
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Morag Rose Hunter, Natasha Lillia Grimsey & Michelle Glass. (2016) Sulfation of the FLAG epitope is affected by co-expression of G protein-coupled receptors in a mammalian cell model. Scientific Reports 6:1.
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Diego Guidolin, Cinzia Tortorella, Raffaele De Caro & Luigi F. Agnati. 2016. The Fractal Geometry of the Brain. The Fractal Geometry of the Brain 137 156 .
Luigi F. Agnati, Diego Guidolin, Guido Maura, Manuela Marcoli, Giuseppina Leo, Chiara Carone, Raffaele De Caro, Susanna Genedani, Dasiel O. Borroto-Escuela & Kjell Fuxe. (2014) Information handling by the brain: proposal of a new “paradigm” involving the roamer type of volume transmission and the tunneling nanotube type of wiring transmission. Journal of Neural Transmission 121:12, pages 1431-1449.
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Marc Brugarolas, Gemma Navarro, Eva Martínez-Pinilla, Edgar Angelats, Vicent Casadó, José L. Lanciego & Rafael Franco. (2014) G-Protein-Coupled Receptor Heteromers as Key Players in the Molecular Architecture of the Central Nervous System. CNS Neuroscience & Therapeutics 20:8, pages 703-709.
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Amresh Prakash & Pratibha Mehta Luthra. (2012) Insilico study of the A2AR?D2R kinetics and interfacial contact surface for heteromerization. Amino Acids 43:4, pages 1451-1464.
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Paulina K. Wrzal, Dominic Devost, Darlaine P?trin, Eug?nie Goupil, Christian Iorio-Morin, St?phane A. Laporte, Hans H. Zingg & Terence E. H?bert. (2012) Allosteric interactions between the oxytocin receptor and the ?2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization. Cellular Signalling 24:1, pages 342-350.
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Diego Guidolin, Giovanna Albertin, Michele Guescini, Kjell Fuxe & Luigi F. Agnati. (2011) Central Nervous System and Computation. The Quarterly Review of Biology 86:4, pages 265-285.
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Diego Guidolin, Francisco Ciruela, Susanna Genedani, Michele Guescini, Cinzia Tortorella, Giovanna Albertin, Kjell Fuxe & Luigi Francesco Agnati. (2011) Bioinformatics and mathematical modelling in the study of receptor?receptor interactions and receptor oligomerization. Biochimica et Biophysica Acta (BBA) - Biomembranes 1808:5, pages 1267-1283.
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