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Review Article

Hydroxamic acids (therapeutics and mechanism): chemistry, acyl nitroso, nitroxyl, reactive oxygen species, and cell signaling

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Pages 10-19 | Received 10 May 2010, Accepted 26 May 2010, Published online: 30 Jun 2010

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Uri Samuni, Eric Maimon & Sara Goldstein. (2018) A kinetic study of the oxidation of hydroxamic acids by compounds I and II of horseradish peroxidase: Effect of transition metal ions. Journal of Coordination Chemistry 71:11-13, pages 1728-1737.
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María M. Gutiérrez, Alejandra E. Almaraz, Sara E. Bari, José A. Olabe & Valentín T. Amorebieta. (2015) The HNO donor ability of hydroxamic acids upon oxidation with cyanoferrates(III). Journal of Coordination Chemistry 68:17-18, pages 3236-3246.
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Shenyao Wang, Xiaoyu Lv, Zhenyu Zhao, Yixin Chen, Zhong Chen, Wenjun Lin, Haoran Li & Congmin Wang. (2021) Highly Efficient and Reversible Absorption and Oxidation of Low-Concentration Nitric Oxide by Functionalized Ionic Liquids. ACS Sustainable Chemistry & Engineering 9:20, pages 7154-7159.
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Donald J. AbrahamBryan Norman. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 28 .
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Eric Maimon, Amram Samuni & Sara Goldstein. (2018) Nitrogen Dioxide Reaction with Nitroxide Radical Derived from Hydroxamic Acids: The Intermediacy of Acyl Nitroso and Nitroxyl (HNO). The Journal of Physical Chemistry A 122:15, pages 3747-3753.
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Misal Giuseppe Memeo & Paolo Quadrelli. (2017) Generation and Trapping of Nitrosocarbonyl Intermediates. Chemical Reviews 117:3, pages 2108-2200.
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D. Basudhar, G. Bharadwaj, D.J. Salmon & K.M. Miranda. 2017. The Chemistry and Biology of Nitroxyl (HNO). The Chemistry and Biology of Nitroxyl (HNO) 11 36 .
Rita Mocci, Lidia De Luca, Francesco Delogu & Andrea Porcheddu. (2016) An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives. Advanced Synthesis & Catalysis 358:19, pages 3135-3144.
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Sara Goldstein & Amram Samuni. 2015. NOx Related Chemistry. NOx Related Chemistry 315 333 .
Reeta Yadav, Sara Goldstein, Mohamed O. Nasef, Wendy Lee & Uri Samuni. (2014) Synergistic activity of acetohydroxamic acid on prokaryotes under oxidative stress: The role of reactive nitrogen species. Free Radical Biology and Medicine 77, pages 291-297.
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YANXIA ZHAO, DANDAN YU, HONGGE WU, HONGLI LIU, HONGXIA ZHOU, RUNXIA GU, RUIGUANG ZHANG, SHENG ZHANG & GANG WU. (2014) Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo. International Journal of Oncology 44:2, pages 451-458.
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Manish K. Gupta, Gagandip Singh & Swati Gupta. 2013. Hydroxamic Acids. Hydroxamic Acids 173 204 .
Rasika Fernando, Jonathan M. Shirley, Emilio Torres, Hollie K. Jacobs & Aravamudan S. Gopalan. (2012) Preparation of bifunctional isocyanate hydroxamate linkers: synthesis of carbamate and urea tethered polyhydroxamic acid chelators. Tetrahedron Letters 53:47, pages 6367-6371.
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Yuval Samuni, Uri Samuni & Sara Goldstein. (2012) The mechanism underlying nitroxyl and nitric oxide formation from hydroxamic acids. Biochimica et Biophysica Acta (BBA) - General Subjects 1820:10, pages 1560-1566.
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Daniela AndreiDebra J. SalmonSonia DonzelliAzadeh WahabJohn R. KloseMichael L. CitroJoseph E. SaavedraDavid A. WinkKatrina M. MirandaLarry K. Keefer. (2010) Dual Mechanisms of HNO Generation by a Nitroxyl Prodrug of the Diazeniumdiolate (NONOate) Class. Journal of the American Chemical Society 132:46, pages 16526-16532.
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