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Journal of Receptor Research Volume 14, 1994 - Issue 3-4
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Research Article

Modeling of G-Protein Coupled Receptors with Bacteriorhodopsin as a Template. A Novel Approach Based on Interaction Energy Differences

D. Röper Institut für Biochemie Rheinisch-Westfälische Technische Hochschule Aachen Klinikum Pauwelsstr, 30, 52057, Aachen, Germany
,
E. Jacoby Institut für Biochemie Rheinisch-Westfälische Technische Hochschule Aachen Klinikum Pauwelsstr, 30, 52057, Aachen, Germany
,
P. Krüger Institut für Biochemie Rheinisch-Westfälische Technische Hochschule Aachen Klinikum Pauwelsstr, 30, 52057, Aachen, Germany
,
M. Engels Institut für Biochemie Rheinisch-Westfälische Technische Hochschule Aachen Klinikum Pauwelsstr, 30, 52057, Aachen, Germany
,
J. Grötzinger Institut für Biochemie Rheinisch-Westfälische Technische Hochschule Aachen Klinikum Pauwelsstr, 30, 52057, Aachen, Germany
,
A. Wollmer Institut für Biochemie Rheinisch-Westfälische Technische Hochschule Aachen Klinikum Pauwelsstr, 30, 52057, Aachen, Germany
&
W. Straßburger Grünenthal GmbH Forschungszentrum Zieglerstr, 6 52078, Aachen, Germany
 show all
Pages 167-186 | Published online: 26 Sep 2008

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Edgar Jacoby, Alain Boudon, Nathalie Kucharczyk, AndrÉ Michel & Jean-Luc Fauchère. (1997) A Structural Rationale for the Design of Water Soluble Peptide-Derived Neurokinin-1 Antagonists. Journal of Receptors and Signal Transduction 17:6, pages 855-873.
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Articles from other publishers (13)

Michael Sabio & Sidney W. Topiol. 2010. GPCR Molecular Pharmacology and Drug Targeting. GPCR Molecular Pharmacology and Drug Targeting 434 459 .
Sid Topiol & Michael Sabio. (2009) X-ray structure breakthroughs in the GPCR transmembrane region. Biochemical Pharmacology 78:1, pages 11-20.
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Marvin C. GershengornRoman Osman. (2001) Minireview: Insights into G Protein-Coupled Receptor Function Using Molecular Models**The work from our laboratories was supported by USPHS Grant DK-43036.. Endocrinology 142:1, pages 2-10.
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Ulrik Gether. (2000) Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors. Endocrine Reviews 21:1, pages 90-113.
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Andrew J. Morris & Craig C. Malbon. (1999) Physiological Regulation of G Protein-Linked Signaling. Physiological Reviews 79:4, pages 1373-1430.
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Thomas P. Sakmar. 1997. 1 34 .
Cor J. Grol & Johanna M. Jansen. (1996) The high affinity melatonin binding site probed with conformationally restricted ligands—II. Homology modeling of the receptor. Bioorganic & Medicinal Chemistry 4:8, pages 1333-1339.
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Ute Raffetseder, Detlef Roper, Laurence Mery, Claudia Gietz, Andreas Klos, Joachim Grotzinger, Axel Wollmer, Francois Boulay, Jorg Kohl & Wilfried Bautsch. (1996) Site-Directed Mutagenesis of Conserved Charged Residues in the Helical Region of the Human C5a Receptor. Arg206 Determines High-Affinity Binding Sites of C5a Receptor. European Journal of Biochemistry 235:1-2, pages 82-90.
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KONRAD F. KOEHLER, SHASHIDHAR N. RAO & JAMES P. SNYDER. 1996. Guidebook on Molecular Modeling in Drug Design. Guidebook on Molecular Modeling in Drug Design 235 336 .
K. Fahmy, F. Siebert & T.P. Sakmar. (1995) Photoactivated state of rhodopsin and how it can form. Biophysical Chemistry 56:1-2, pages 171-181.
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M. -P. Joseph, B. Maigret, J. -C. Bonnafous, J. Marie & H. A. Scheraga. (1995) A computer modeling postulated mechanism for angiotensin II receptor activation. Journal of Protein Chemistry 14:5, pages 381-398.
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Thomas P. Sakmar & Karim Fahmy. (1995) Properties and Photoactivity of Rhodopsin Mutants. Israel Journal of Chemistry 35:3-4, pages 325-337.
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F. M. L. G. Stamato, M. Paulino, R. Garratt, C. M. Soares & O. Tapia. (1994) Computer assisted simulations and molecular graphics methods in molecular design 2. Proteinases and receptor and transport proteins. Molecular Engineering 4:4, pages 375-414.
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