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Pharmaceutical Development and Technology Volume 20, 2015 - Issue 1
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Research Article

Thermoresponsive fluconazole gels for topical delivery: rheological and mechanical properties, in vitro drug release and anti-fungal efficacy

Sarath C. R. GandraDepartment of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA and
,
Sanko NguyenDepartment of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA and
,
Sami NazzalDepartment of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA
,
Alaadin AlayoubiDepartment of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA
,
Rose JungDepartment of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA and
&
Jerry NesamonyDepartment of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA and Correspondence[email protected]
Pages 41-49 | Received 26 Jul 2013, Accepted 09 Sep 2013, Published online: 25 Oct 2013

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Divya Sharma, Faraj Atassi, Steve Cook, Stacey Marden, Jianyan Wang, Aixiang Xue, David J. Wagner, Guangnong Zhang & Wenzhan Yang. (2021) Experimental design, development and evaluation of extended release subcutaneous thermo-responsive in situ gels for small molecules in drug discovery. Pharmaceutical Development and Technology 26:10, pages 1079-1089.
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Ming-Hua Xie, Min Ge, Jia-Bei Peng, Xiao-Rui Jiang, Ding-Sheng Wang, Li-Qiang Ji, Yin Ying & Zeng Wang. (2019) In-vivo anti-tumor activity of a novel poloxamer-based thermosensitive in situ gel for sustained delivery of norcantharidin. Pharmaceutical Development and Technology 24:5, pages 623-629.
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Articles from other publishers (16)

Kwadwo Mfoafo, Yadollah Omidi & Hossein Omidian. (2023) Thermoresponsive mucoadhesive hybrid gels in advanced drug delivery systems. International Journal of Pharmaceutics 636, pages 122799.
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Denise Bellotti, Maria D’Accolti, Walter Pula, Nicolas Huang, Fanny Simeliere, Elisabetta Caselli, Elisabetta Esposito & Maurizio Remelli. (2023) Calcitermin-Loaded Smart Gels Activity against Candida albicans: A Preliminary In Vitro Study. Gels 9:2, pages 165.
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Heba F. Salem, Adel A. Ali, Yasmine K. Rabea, Fatma I. Abo El-Ela & Rasha A. Khallaf. (2022) Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal. Drug Delivery and Translational Research 12:12, pages 3083-3103.
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Kwadwo Mfoafo, Young Kwon, Yadollah Omidi & Hossein Omidian. (2022) Contemporary applications of thermogelling PEO-PPO-PEO triblock copolymers. Journal of Drug Delivery Science and Technology 70, pages 103182.
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Dalia M.N. Abouhussein. (2021) Enhanced transdermal permeation of BCS class IV aprepitant using binary ethosome: Optimization, characterization and ex vivo permeation. Journal of Drug Delivery Science and Technology 61, pages 102185.
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Michael T. Cook, Peter Haddow, Stewart B. Kirton & William J. McAuley. (2020) Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare. Advanced Functional Materials 31:8, pages 2008123.
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Frank Oppong, Zehui Li, Ehsan Akbari Fakhrabadi, Tanvi Raorane, Paras M. Giri, Matthew W. Liberatore, Jeffrey G. Sarver, Christopher J. Trabbic, Corey E. Hosier, Paul W. Erhardt, William A. Maltese & Jerry Nesamony. (2020) Investigating the Potential to Deliver and Maintain Plasma and Brain Levels of a Novel Practically Insoluble Methuosis Inducing Anticancer Agent 5-Methoxy MOMIPP Through an Injectable In Situ Forming Thermoresponsive Hydrogel Formulation. Journal of Pharmaceutical Sciences 109:9, pages 2719-2728.
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Eun-Sol Ha, Seon-Kwang Lee, Du Hyung Choi, Seong Hoon Jeong, Sung-Joo Hwang & Min-Soo Kim. (2019) Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs. Journal of Pharmaceutical Investigation 50:3, pages 231-250.
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Abeer Khattab, Sarah Marzok & Magdy Ibrahim. (2019) Development of optimized mucoadhesive thermosensitive pluronic based in situ gel for controlled delivery of Latanoprost: Antiglaucoma efficacy and stability approaches. Journal of Drug Delivery Science and Technology 53, pages 101134.
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Rania Hamed, Yasmeen Al-Adhami & Rana Abu-Huwaij. (2019) Concentration of a microemulsion influences the mechanical properties of ibuprofen in situ microgels. International Journal of Pharmaceutics 570, pages 118684.
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Davide Zanon, Chiara Volpato, Riccardo Addobbati, Stefano Loiacono, Alessandra Maestro, Egidio Barbi, Natalia Maximova, Maria Grazia Mamolo & Daniele Zampieri. (2019) Stability of a novel Lidocaine, Adrenaline and Tetracaine sterile thermosensitive gel: A ready-to-use formulation. European Journal of Pharmaceutical Sciences 136, pages 104962.
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Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, A.B. Patil & Om Prakash Katare. (2018) Chitosan-tailored lipidic nanoconstructs of Fusidic acid as promising vehicle for wound infections: An explorative study. International Journal of Biological Macromolecules 115, pages 1012-1025.
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Noha Ibrahim El-sherif, Rehab N. Shamma & Ghada Abdelbary. (2018) In-situ gels and nail lacquers as potential delivery systems for treatment of onychomycosis. A comparative study. Journal of Drug Delivery Science and Technology 43, pages 253-261.
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Dalia M.N. Abouhussein, Abeer Khattab, Noha A. Bayoumi, Ashgan F. Mahmoud & Tamer M. Sakr. (2018) Brain targeted rivastigmine mucoadhesive thermosensitive In situ gel: Optimization, in vitro evaluation, radiolabeling, in vivo pharmacokinetics and biodistribution. Journal of Drug Delivery Science and Technology 43, pages 129-140.
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Komal Parmar, Jayvadan K. Patel, Deepak Bhatia & Yashwant V. Pathak. 2018. Drug Delivery for the Retina and Posterior Segment Disease. Drug Delivery for the Retina and Posterior Segment Disease 397 409 .
Magdalena Wróblewska & Katarzyna Winnicka. (2015) The Effect of Cationic Polyamidoamine Dendrimers on Physicochemical Characteristics of Hydrogels with Erythromycin. International Journal of Molecular Sciences 16:9, pages 20277-20289.
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