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Pharmaceutical Development and Technology Volume 21, 2016 - Issue 2
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Research Article

A mechanistic investigation on the utilization of lactose as a protective agent for multi-unit pellet systems

Wun Chyi ChinDepartment of Pharmacy, GEA-NUS Pharmaceutical Processing Research Laboratory, National University of Singapore, Singapore
,
Lai Wah ChanDepartment of Pharmacy, GEA-NUS Pharmaceutical Processing Research Laboratory, National University of Singapore, Singapore
&
Paul Wan Sia HengDepartment of Pharmacy, GEA-NUS Pharmaceutical Processing Research Laboratory, National University of Singapore, SingaporeCorrespondence[email protected]
Pages 222-230 | Received 22 Aug 2014, Accepted 20 Nov 2014, Published online: 18 Dec 2014

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Mariana Babayeva, Alexander A. Marfo, Ryan Wolfe, Yin C. S. Hlaing, Zvi G. Loewy & Bilge A. Selvi. (2019) Studying the factors that impact the dissolution characteristic of complex drug product. Pharmaceutical Development and Technology 24:10, pages 1200-1209.
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Articles from other publishers (10)

Chuting Shi, Haiyue Zhao, Ying Fang, Lan Shen & Lijie Zhao. (2023) Lactose in tablets: Functionality, critical material attributes, applications, modifications and co-processed excipients. Drug Discovery Today 28:9, pages 103696.
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Daniel Robin Thio, Quinton Aguilera, Janice Ke Xin Yeoh, Paul Wan Sia Heng & Lai Wah Chan. (2023) An evaluation of microcrystalline cellulose attributes affecting compaction-induced pellet coat damage through a multi-faceted analysis. International Journal of Pharmaceutics 643, pages 123245.
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Daniel Robin Thio, Paul Wan Sia Heng & Lai Wah Chan. (2022) MUPS Tableting—Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets. Pharmaceutics 14:12, pages 2812.
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Surendra Agrawal, Joneth Fernandes, Fuzail Shaikh & Vishwa Patel. (2022) Quality aspects in the development of pelletized dosage forms. Heliyon 8:2, pages e08956.
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Ramy N. Elsergany, Lai Wah Chan & Paul Wan Sia Heng. (2020) Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting. International Journal of Pharmaceutics 586, pages 119573.
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Tze Ning Hiew, Yu Harn Tian, Huei Ming Tan & Paul Wan Sia Heng. (2020) A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets. European Journal of Pharmaceutics and Biopharmaceutics 146, pages 93-100.
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Nihad Al-Hashimi, Nazish Begg, Raid Alany, Hany Hassanin & Amr Elshaer. (2018) Oral Modified Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and Nanoparticles. Pharmaceutics 10:4, pages 176.
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Tingting Peng, Peipei Yang, Chune Zhu, Xuejuan Zhang, Xinyi Wang, Hao Ran, Xuequn Bai, Jiwen Zhang, Chuan-yu Wu, Xin Pan & Chuanbin Wu. (2018) Mechanistic investigation on the performance of Huperzine A loaded microparticles based on ultra-fine particle processing system. Powder Technology 326, pages 370-378.
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Tongkai Chen, Jian Li, Ting Chen, Changquan Calvin Sun & Ying Zheng. (2017) Tablets of multi-unit pellet system for controlled drug delivery. Journal of Controlled Release 262, pages 222-231.
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Min Xu, Paul Wan Sia Heng & Celine Valeria Liew. (2016) Formulation and process strategies to minimize coat damage for compaction of coated pellets in a rotary tablet press: A mechanistic view. International Journal of Pharmaceutics 499:1-2, pages 29-37.
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