Advanced search
Publication Cover
Pharmaceutical Development and Technology Volume 22, 2017 - Issue 8
Submit an article Journal homepage
244
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Parenteral dosage form development and testing of dimethyl trisulfide, as an antidote candidate to combat cyanide intoxication

Kristof KovacsDepartment of Chemistry, Sam Houston State University, Huntsville, TX, USA and
,
Anna C. DukeDepartment of Chemistry, Sam Houston State University, Huntsville, TX, USA and
,
Marla ShiffletDepartment of Chemistry, Sam Houston State University, Huntsville, TX, USA and
,
Brittany WinnerDepartment of Chemistry, Sam Houston State University, Huntsville, TX, USA and
,
Stephen A. LeeDepartment of Chemistry, Sam Houston State University, Huntsville, TX, USA and
,
Gary A. RockwoodU.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Aberdeen, MD, USA
&
Ilona PetrikovicsDepartment of Chemistry, Sam Houston State University, Huntsville, TX, USA and Correspondence[email protected]
 show all
Pages 958-963 | Received 11 Oct 2015, Accepted 24 Nov 2015, Published online: 07 Jan 2016

Citations (12)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

D. S. Lippner, D. M. Hildenberger, M. O. Rhoomes, J. N. Winborn, H. Dixon, J. McDonough & G. A. Rockwood. (2022) A novel aqueous dimethyl trisulfide formulation is effective at low doses against cyanide toxicity in non-anesthetized mice and rats. Clinical Toxicology 60:1, pages 83-94.
Read now
Tara B. Hendry-Hofer, Alyssa E. Witeof, Dennean S. Lippner, Patrick C. Ng, Sari B. Mahon, Matthew Brenner, Gary A. Rockwood & Vikhyat S. Bebarta. (2019) Intramuscular dimethyl trisulfide: efficacy in a large swine model of acute severe cyanide toxicity. Clinical Toxicology 57:4, pages 265-270.
Read now
Márton Kiss, Ilona Petrikovics & David E. Thompson. (2018) Methemoglobin Forming Effect of Dimethyl Trisulfide in Mice. Hemoglobin 42:5-6, pages 315-319.
Read now
Susan M. DeLeon, Jason D. Downey, Diane M. Hildenberger, Melissa O. Rhoomes, Lamont Booker, Gary A. Rockwood & Kelly A. Basi. (2018) DMTS is an effective treatment in both inhalation and injection models for cyanide poisoning using unanesthetized mice. Clinical Toxicology 56:5, pages 332-341.
Read now

Articles from other publishers (8)

Matthew M Behymer, Huaping Mo, Naoaki Fujii, Vallabh Suresh, Ari S Arzumanian, Adriano Chan, Anjali K Nath, Robyn McCain, Calum A MacRae, Randall Peterson, Gerry R Boss, Vincent Jo Davisson & Gregory T Knipp. (2023) Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers. Toxicological Sciences.
Crossref
Matthew M. Behymer, Huaping Mo, Naoaki Fujii, Vallabh Suresh, Adriano Chan, Jangweon Lee, Anjali K. Nath, Kusumika Saha, Sari B. Mahon, Matthew Brenner, Calum A. MacRae, Randall Peterson, Gerry R. Boss, Gregory T. Knipp & Vincent Jo Davisson. (2022) Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures. Chemical Research in Toxicology 35:11, pages 1983-1996.
Crossref
Eszter Fliszár-Nyúl, Rita Csepregi, Gábor Benkovics, Lajos Szente & Miklós Poór. (2022) Testing the Protective Effects of Sulfobutylether-Βeta-Cyclodextrin (SBECD) and Sugammadex against Chlorpromazine-Induced Acute Toxicity in SH-SY5Y Cell Line and in NMRI Mice. Pharmaceutics 14:9, pages 1888.
Crossref
Nathaniel C. Rice, Noah A. Rauscher, William L. Wilkins, Dennean S. Lippner, Gary A. Rockwood & Todd M. Myers. (2019) Behavioural and physiological assessments of dimethyl trisulfide treatment for acute oral sodium cyanide poisoning. Basic & Clinical Pharmacology & Toxicology 125:3, pages 289-303.
Crossref
Jangwoen Lee, Gary Rockwood, Brian Logue, Erica Manandhar, Ilona Petrikovics, Changhoon Han, Vik Bebarta, Sari B. Mahon, Tanya Burney & Matthew Brenner. (2018) Monitoring Dose Response of Cyanide Antidote Dimethyl Trisulfide in Rabbits Using Diffuse Optical Spectroscopy. Journal of Medical Toxicology 14:4, pages 295-305.
Crossref
Xinmei Dong, Lóránd Kiss, Ilona Petrikovics & David E. Thompson. (2017) Reaction of Dimethyl Trisulfide with Hemoglobin. Chemical Research in Toxicology 30:9, pages 1661-1663.
Crossref
Lóránd Kiss, Secondra Holmes, Ching-En Chou, Xinmei Dong, James Ross, Denise Brown, Brooke Mendenhall, Valerie Coronado, Deepthika De Silva, Gary A. Rockwood, Ilona Petrikovics & David E. Thompson. (2017) Method development for detecting the novel cyanide antidote dimethyl trisulfide from blood and brain, and its interaction with blood. Journal of Chromatography B 1044-1045, pages 149-157.
Crossref
Deepthika De Silva, Steven Lee, Anna Duke, Siva Angalakurthi, Ching-En Chou, Afshin Ebrahimpour, David E. Thompson & Ilona Petrikovics. (2016) Intravascular Residence Time Determination for the Cyanide Antidote Dimethyl Trisulfide in Rat by Using Liquid-Liquid Extraction Coupled with High Performance Liquid Chromatography. Journal of Analytical Methods in Chemistry 2016, pages 1-6.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.