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Research Article

Optimization and Characterization of a pH-Independent Extended-Release Hydrophuic Matrix Tablet

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Pages 25-31 | Received 17 Jun 1996, Accepted 30 Sep 1996, Published online: 27 Sep 2008

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Natalia Veronica, Paul Wan Sia Heng & Celine Valeria Liew. (2023) Alginate-based matrix tablets for drug delivery. Expert Opinion on Drug Delivery 20:1, pages 115-130.
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Chika Taniguchi, Yohei Kawabata, Koichi Wada, Shizuo Yamada & Satomi Onoue. (2014) Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility. Expert Opinion on Drug Delivery 11:4, pages 505-516.
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Bistra Kostova, Elena Kamenska, Ivo Ivanov, George Momekov, Dimitar Rachev & George Georgiev. (2008) Verapamil Hydrochloride Release Characteristics from New Copolymer Zwitterionic Matrix Tablets. Pharmaceutical Development and Technology 13:4, pages 311-321.
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S. Gutsche, M. Krause & H. Kranz. (2008) Strategies to Overcome pH-Dependent Solubility of Weakly Basic Drugs by Using Different Types of Alginates. Drug Development and Industrial Pharmacy 34:12, pages 1277-1284.
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C. Guthmann, R. Lipp, T. Wagner & H. Kranz. (2007) Development of a Multiple Unit Pellet Formulation for a Weakly Basic Drug. Drug Development and Industrial Pharmacy 33:3, pages 341-349.
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Dale L. Munday. (2003) Film Coated Pellets Containing Verapamil Hydrochloride: Enhanced Dissolution into Neutral Medium. Drug Development and Industrial Pharmacy 29:5, pages 575-583.
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Frederick Walters. (1999) Sequential Simplex Optimization - An Update. Analytical Letters 32:2, pages 193-212.
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Safwan Abdel Rahim, Nizar Al-Zoubi, Heba Khader, Rahaf Alwaraydat & Faisal Al-Akayleh. (2023) Ethanol-induced dose dumping from sodium alginate matrix tablets: Investigation of the effects of medium viscosity and pH. International Journal of Pharmaceutics 632, pages 122568.
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Farah Deeba Zahoor, Kerstin T. MaderPeter Timmins, Jonathan BrownChris Sammon. (2020) Investigation of Within-Tablet Dynamics for Extended Release of a Poorly Soluble Basic Drug from Hydrophilic Matrix Tablets Using ATR–FTIR Imaging. Molecular Pharmaceutics 17:4, pages 1090-1099.
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Peter Timmins, Divyakant Desai, Wei Chen, Patrick Wray, Jonathan Brown & Sarah Hanley. (2016) Advances in mechanistic understanding of release rate control mechanisms of extended-release hydrophilic matrix tablets. Therapeutic Delivery 7:8, pages 553-572.
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Martin Kuentz, René Holm & David P. Elder. (2016) Methodology of oral formulation selection in the pharmaceutical industry. European Journal of Pharmaceutical Sciences 87, pages 136-163.
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Nizar Al-Zoubi, Hatim S. Alkhatib, Ghadah Alobaidi, Safwan Abdel-Rahim, Wasfy Obeidat & Stavros Malamataris. (2015) Optimization of pH-independent chronotherapeutic release of verapamil HCl from three-layer matrix tablets. International Journal of Pharmaceutics 494:1, pages 296-303.
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Ali Nokhodchi, Dasha Palmer, Kofi Asare-Addo, Marina Levina & Ali Rajabi-Siahboomi. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 23 49 .
Ali Mujtaba, Mushir Ali & Kanchan Kohli. (2014) Statistical optimization and characterization of pH-independent extended-release drug delivery of cefpodoxime proxetil using Box–Behnken design. Chemical Engineering Research and Design 92:1, pages 156-165.
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Jonathan Brown, Sarah L. Hanley, Samuel R. Pygall, Paolo Avalle, Hywel D. Williams & Colin D. Melia. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 165 189 .
Colin D. Melia & Peter Timmins. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 87 122 .
Marina Levina & Ali R. Rajabi-Siahboomi. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 53 85 .
Peter Timmins & Samuel R. Pygall. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 257 280 .
Nikhil Malewar, Makarand Avachat, Varsha Pokharkar & Shirish Kulkarni. (2013) Controlled Release of Ropinirole Hydrochloride from a Multiple Barrier Layer Tablet Dosage Form: Effect of Polymer Type on Pharmacokinetics and IVIVC. AAPS PharmSciTech 14:3, pages 1178-1189.
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Sarah J. Nicholson, Peter Timmins, Randy C. Dockens, Alyson Connor, Robert Croop, Peter Ferrie, Jianing Zeng, Andrew B. Dennis & Ian Wilding. (2012) Development of oral extended release formulations of 6‐hydroxybuspirone. Biopharmaceutics & Drug Disposition 33:9, pages 522-535.
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Sandip B. Tiwari, James DiNunzio & Ali Rajabi-Siahboomi. 2011. Controlled Release in Oral Drug Delivery. Controlled Release in Oral Drug Delivery 131 159 .
Shahla Soltanpour & Abolghasem Jouyban. (2009) Solubility of Lamotrigine and Diazepam in Propylene Glycol + Water + Carboxymethyl Cellulose at a Temperature of 298.2 K. Journal of Chemical & Engineering Data 55:8, pages 2890-2893.
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Samuel R. Pygall, Sarah Kujawinski, Peter Timmins & Colin D. Melia. (2010) The suitability of tris(hydroxylmethyl) aminomethane (THAM) as a buffering system for hydroxypropyl methylcellulose (HPMC) hydrophilic matrices containing a weak acid drug. International Journal of Pharmaceutics 387:1-2, pages 93-102.
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Shahla Soltanpour, William E. AcreeJr.Jr. & Abolghasem Jouyban. (2009) Effects of Different Concentrations of Poly(vinyl pyrrolidone) on the Solubility of Lamotrigine and Diazepam in Ethanol + Water Mixtures at 298.2 K. Journal of Chemical & Engineering Data 55:1, pages 570-573.
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Kwang-Ho Cha, Junsung Park, Wonkyung Cho, Dong-Geon Gu, Kihyang Jeong & Sung-Joo Hwang. (2009) Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia. Archives of Pharmacal Research 32:11, pages 1593-1598.
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C. Guthmann, R. Lipp, T. Wagner & H. Kranz. (2008) Development of a novel osmotically driven drug delivery system for weakly basic drugs. European Journal of Pharmaceutics and Biopharmaceutics 69:2, pages 667-674.
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Sandip B. Tiwari & Ali R. Rajabi-Siahboomi. 2008. Drug Delivery Systems. Drug Delivery Systems 217 243 .
Bistra Kostova & Dimitar Rachev. (2007) New co-polymer zwitterionic matrices for sustained release of verapamil hydrochloride. Acta Pharmaceutica 57:4, pages 429-439.
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Sherif I. Farag Badawy & Munir A. Hussain. (2007) Microenvironmental pH Modulation in Solid Dosage Forms. Journal of Pharmaceutical Sciences 96:5, pages 948-959.
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A Dashevsky, K Kolter & R Bodmeier. (2004) pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat® SR 30 D and the enteric polymer dispersion Kollicoat® MAE 30 DP. European Journal of Pharmaceutics and Biopharmaceutics 58:1, pages 45-49.
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A Streubel, J Siepmann, A Dashevsky & R Bodmeier. (2000) pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets. Journal of Controlled Release 67:1, pages 101-110.
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