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Amyloid
The Journal of Protein Folding Disorders
Volume 7, 2000 - Issue 3
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Original Article

Amyloid peptide channels: Blockade by zinc and inhibition by Congo red (amyloid channel block)

Yutaka Hirakura Department of Psychiatry, Neuropsychiatric Institute, Brain Research Institute, Los Angeles, CA, USA; Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA, USA; West Los Angeles VA Medical Center, Los Angeles, CA, USA
,
Wendy W. Yiu Department of Psychiatry, Neuropsychiatric Institute, Brain Research Institute, Los Angeles, CA, USA; Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA, USA; West Los Angeles VA Medical Center, Los Angeles, CA, USA
,
Andrew Yamamoto Department of Psychiatry, Neuropsychiatric Institute, Brain Research Institute, Los Angeles, CA, USA; Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA, USA; West Los Angeles VA Medical Center, Los Angeles, CA, USA
&
Bruce L. Kagan Department of Psychiatry, Neuropsychiatric Institute, Brain Research Institute, Los Angeles, CA, USA; Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA, USA; West Los Angeles VA Medical Center, Los Angeles, CA, USACorrespondence[email protected]
Pages 194-199 | Received 28 Apr 1999, Accepted 26 Oct 1999, Published online: 06 Jul 2009

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Yutaka Hirakura, Isabel Carreras, Jean D. Sipe & Bruce L. Kagan. (2002) Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid 9:1, pages 13-23.
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Yutuka Hirakura & Bruce L. Kagan. (2001) Pore formation by beta-2-microglobulin: A mechanism for the pathogenesis of dialysis associated amyloidosis. Amyloid 8:2, pages 94-100.
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Articles from other publishers (58)

Daniela Meleleo, Giuseppe Cibelli, Anna Valenzano, Maria Mastrodonato & Rosanna Mallamaci. (2023) The Effect of Calcium Ions on hIAPP Channel Activity: Possible Implications in T2DM. Membranes 13:11, pages 878.
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Sidney S. Dicke, Michał Maj, Caitlyn R. Fields & Martin T. Zanni. (2022) Metastable intermediate during hIAPP aggregation catalyzed by membranes as detected with 2D IR spectroscopy. RSC Chemical Biology 3:7, pages 931-940.
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Hang Zhao, Xuerong Huang & Zhiqian Tong. (2021) Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives. ChemMedChem 16:22, pages 3376-3390.
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Michele F. M. Sciacca, Carmelo La Rosa & Danilo Milardi. (2021) Amyloid-Mediated Mechanisms of Membrane Disruption. Biophysica 1:2, pages 137-156.
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Federica Scollo & Carmelo La Rosa. (2020) Amyloidogenic Intrinsically Disordered Proteins: New Insights into Their Self-Assembly and Their Interaction with Membranes. Life 10:8, pages 144.
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M. Meghna, B. Athira, T.S. Saranya & Asha Asokan Manakadan. (2019) in silico Single Nucleotide Polymorphism Prediction and Design for Targeting Amyloid Precursor Protein in Alzheimers Disease. Asian Journal of Chemistry 31:9, pages 1959-1965.
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Michael C. Owen, David Gnutt, Mimi Gao, Sebastian K. T. S. Wärmländer, Jüri Jarvet, Astrid Gräslund, Roland Winter, Simon Ebbinghaus & Birgit Strodel. (2019) Effects of in vivo conditions on amyloid aggregation . Chemical Society Reviews 48:14, pages 3946-3996.
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S. S. Efimova & O. S. Ostroumova. (2019) Mechanisms of Regulation of Amyloid-Induced Permeability of Model Lipid Membranes by Polyphenols. Cell and Tissue Biology 13:4, pages 312-320.
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Aleksandr Kakinen, Ibrahim Javed, Ava Faridi, Thomas P. Davis & Pu Chun Ke. (2018) Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860:9, pages 1803-1809.
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Min Li, Wanrong Zhang, Wei Wang, Qing He, Mengmei Yin, Xue Qin, Tongyu Zhang & Ting Wu. (2017) Imidazole improves cognition and balances Alzheimer's‐like intracellular calcium homeostasis in transgenic Drosophila model. Neurourology and Urodynamics 37:4, pages 1250-1257.
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Zhuoyang Lu, Hua Li, Chen Hou, Yunhua Peng, Jiangang Long & Jiankang Liu. (2016) Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells. European Biophysics Journal 46:5, pages 415-424.
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Pu Chun Ke, Marc-Antonie Sani, Feng Ding, Aleksandr Kakinen, Ibrahim Javed, Frances Separovic, Thomas P. Davis & Raffaele Mezzenga. (2017) Implications of peptide assemblies in amyloid diseases. Chemical Society Reviews 46:21, pages 6492-6531.
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Yanting Xing, Emily H. Pilkington, Miaoyi Wang, Cameron J. Nowell, Aleksandr Kakinen, Yunxiang Sun, Bo Wang, Thomas P. Davis, Feng Ding & Pu Chun Ke. (2017) Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide. Physical Chemistry Chemical Physics 19:45, pages 30627-30635.
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Antonio Magrì, Diego La Mendola, Vincenzo Giuseppe Nicoletti, Giuseppe Pappalardo & Enrico Rizzarelli. (2016) New Insight in Copper‐Ion Binding to Human Islet Amyloid: The Contribution of Metal‐Complex Speciation To Reveal the Polypeptide Toxicity. Chemistry – A European Journal 22:37, pages 13287-13300.
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Judith Miklossy & Patrick L. McGeer. (2016) Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation. Aging 8:4, pages 575-588.
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Jun Xiang Yin, Marwan Maalouf, Pengcheng Han, Minglei Zhao, Ming Gao, Turner Dharshaun, Christopher Ryan, Julian Whitelegge, Jie Wu, David Eisenberg, Eric M. Reiman, Felix E. Schweizer & Jiong Shi. (2016) Ketones block amyloid entry and improve cognition in an Alzheimer's model. Neurobiology of Aging 39, pages 25-37.
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Abhisek Mukherjee, Diego Morales-Scheihing, Peter C. Butler & Claudio Soto. (2015) Type 2 diabetes as a protein misfolding disease. Trends in Molecular Medicine 21:7, pages 439-449.
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Mimi Gao & Roland Winter. (2015) The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP. Journal of Diabetes Research 2015, pages 1-21.
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Ze-bing Huang, Hai-yan Wang, Na-na Sun, Jing-ke Wang, Meng-qin Zhao, Jian-xin Shen, Ming Gao, Ronald P HammerJrJr, Xue-gong Fan & Jie Wu. (2014) Congo red modulates ACh-induced Ca2+ oscillations in single pancreatic acinar cells of mice. Acta Pharmacologica Sinica 35:12, pages 1514-1520.
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Marta S. Fernández. (2014) Human IAPP amyloidogenic properties and pancreatic β-cell death. Cell Calcium 56:5, pages 416-427.
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Zeting Zhang, Chenye Dai, Jia Bai, Guohua Xu, Maili Liu & Conggang Li. (2014) Ca2+ modulating α-synuclein membrane transient interactions revealed by solution NMR spectroscopy. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:3, pages 853-858.
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Martina Pannuzzo, Antonio Raudino, Danilo Milardi, Carmelo La Rosa & Mikko Karttunen. (2013) α-Helical Structures Drive Early Stages of Self-Assembly of Amyloidogenic Amyloid Polypeptide Aggregate Formation in Membranes. Scientific Reports 3:1.
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Vikas Bhat, Max B. Olenick, Brett J. Schuchardt, David C. Mikles, Brian J. Deegan, Caleb B. McDonald, Kenneth L. Seldeen, Dmitry Kurouski, Mohd Hafeez Faridi, Mohammed M. Shareef, Vineet Gupta, Igor K. Lednev & Amjad Farooq. (2013) Heat-induced fibrillation of BclXL apoptotic repressor. Biophysical Chemistry 179, pages 12-25.
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Jeffrey R. Brender, Deborah L. Heyl, Shyamprasad Samisetti, Samuel A. Kotler, Joshua M. Osborne, Ranadheer R. Pesaru & Ayyalusamy Ramamoorthy. (2013) Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20–29) fragments. Physical Chemistry Chemical Physics 15:23, pages 8908.
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Jeffrey R. Brender, Janarthanan Krishnamoorthy, Grazia M. L. Messina, Aniruddha Deb, Subramanian Vivekanandan, Carmelo La Rosa, James E. Penner-Hahn & Ayyalusamy Ramamoorthy. (2013) Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide. Chemical Communications 49:32, pages 3339.
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Michele F.M. Sciacca, Samuel A. Kotler, Jeffrey R. Brender, Jennifer Chen, Dong-kuk Lee & Ayyalusamy Ramamoorthy. (2012) Two-Step Mechanism of Membrane Disruption by Aβ through Membrane Fragmentation and Pore Formation. Biophysical Journal 103:4, pages 702-710.
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Jeffrey R. Brender, Samer Salamekh & Ayyalusamy Ramamoorthy. (2011) Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective. Accounts of Chemical Research 45:3, pages 454-462.
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Theri Leica Degaki, Dahabada H. J. Lopes & Mari Cleide Sogayar. 2012. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases 217 255 .
Andrey Y. Abramov, Maksim Ionov, Evgeny Pavlov & Michael R. Duchen. (2011) Membrane cholesterol content plays a key role in the neurotoxicity of β‐amyloid: implications for Alzheimer’s disease. Aging Cell 10:4, pages 595-603.
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Hyunbum Jang, Fernando Teran Arce, Mirela Mustata, Srinivasan Ramachandran, Ricardo Capone, Ruth Nussinov & Ratnesh Lal. (2011) Antimicrobial Protegrin-1 Forms Amyloid-Like Fibrils with Rapid Kinetics Suggesting a Functional Link. Biophysical Journal 100:7, pages 1775-1783.
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Jeffrey R. Brender, Edgar L. Lee, Kevin Hartman, Pamela T. Wong, Ayyalusamy Ramamoorthy, Duncan G. Steel & Ari Gafni. (2011) Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption. Biophysical Journal 100:3, pages 685-692.
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Masahiro Kawahara, Hironari Koyama, Tetsuya Nagata & Yutaka Sadakane. (2011) Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126. Metallomics 3:7, pages 726.
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Tiehong Zhu, Yinxia Wang, Bingjun He, Jingjing Zang, Qing He & Weihua Zhang. (2011) Islet amyloid polypeptide acts on glucose- stimulated beta cells to reduce voltage-gated calcium channel activation, intracellular Ca2+ concentration, and insulin secretion. Diabetes/Metabolism Research and Reviews 27:1, pages 28-34.
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Hyunbum Jang, Fernando Teran Arce, Srinivasan Ramachandran, Ricardo Capone, Ratnesh Lal & Ruth Nussinov. (2010) β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels. Journal of Molecular Biology 404:5, pages 917-934.
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Hyunbum Jang, Fernando Teran Arce, Srinivasan Ramachandran, Ricardo Capone, Ratnesh Lal & Ruth Nussinov. (2010) Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels. The Journal of Physical Chemistry B 114:29, pages 9445-9451.
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Hyunbum JangFernando Teran ArceSrinivasan RamachandranRicardo CaponeRushana Azimova, Bruce L. Kagan, Ruth Nussinov & Ratnesh Lal. (2010) Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer’s Disease and Down syndrome. Proceedings of the National Academy of Sciences 107:14, pages 6538-6543.
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Hyunbum Jang, Fernando Teran Arce, Ricardo Capone, Srinivasan Ramachandran, Ratnesh Lal & Ruth Nussinov. (2009) Misfolded Amyloid Ion Channels Present Mobile β-Sheet Subunits in Contrast to Conventional Ion Channels. Biophysical Journal 97:11, pages 3029-3037.
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Erene W. Mina, Cristian Lasagna-Reeves, Charles G. Glabe & Rakez Kayed. (2009) Poloxamer 188 Copolymer Membrane Sealant Rescues Toxicity of Amyloid Oligomers In Vitro. Journal of Molecular Biology 391:3, pages 577-585.
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Juan Carlos Diaz, Olga Simakova, Kenneth A. Jacobson, Nelson Arispe & Harvey B. Pollard. (2009) Small molecule blockers of the Alzheimer Aβ calcium channel potently protect neurons from Aβ cytotoxicity. Proceedings of the National Academy of Sciences 106:9, pages 3348-3353.
Crossref
Bruce Kagan. 2008. Protein Science Encyclopedia. Protein Science Encyclopedia 319 342 .
Hyunbum Jang, Jie Zheng, Ratnesh Lal & Ruth Nussinov. (2008) New structures help the modeling of toxic amyloidß ion channels. Trends in Biochemical Sciences 33:2, pages 91-100.
Crossref
Erene W. Mina & Charles G. Glabe. 2008. Advances in Alzheimer’s and Parkinson’s Disease. Advances in Alzheimer’s and Parkinson’s Disease 381 386 .
Nelson Arispe, Juan C. Diaz & Olga Simakova. (2007) Aβ ion channels. Prospects for treating Alzheimer's disease with Aβ channel blockers. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:8, pages 1952-1965.
Crossref
Danielle G. Smith, Roberto Cappai & Kevin J. Barnham. (2007) The redox chemistry of the Alzheimer's disease amyloid β peptide. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:8, pages 1976-1990.
Crossref
Yuri Sokolov, J. Ashot Kozak, Rakez Kayed, Alexandr Chanturiya, Charles Glabe & James E. Hall. (2006) Soluble Amyloid Oligomers Increase Bilayer Conductance by Altering Dielectric Structure. The Journal of General Physiology 128:6, pages 637-647.
Crossref
Christina Priller, Thomas Bauer, Gerda Mitteregger, Bjarne Krebs, Hans A. Kretzschmar & Jochen Herms. (2006) Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein. The Journal of Neuroscience 26:27, pages 7212-7221.
Crossref
Noel D. Lazo, Samir K. Maji, Erica A Fradinger, Gal Bitan & David B. Teplow. 2005. Amyloid Proteins. Amyloid Proteins 384 491 .
Bruce Kagan. 2005. Amyloid Proteins. Amyloid Proteins 318 342 .
Math P. Cuajungco, Christopher J. Frederickson & Ashley I. Bush. 2005. Alzheimer’s Disease. Alzheimer’s Disease 235 254 .
J.D. Green, L. Kreplak, C. Goldsbury, X. Li Blatter, M. Stolz, G.S. Cooper, A. Seelig, J. Kistler & U. Aebi. (2004) Atomic Force Microscopy Reveals Defects Within Mica Supported Lipid Bilayers Induced by the Amyloidogenic Human Amylin Peptide. Journal of Molecular Biology 342:3, pages 877-887.
Crossref
Rekha Srinivasan, Eric M. Jones, Keqian Liu, Jorge Ghiso, Roger E. Marchant & Michael G. Zagorski. (2003) pH-Dependent Amyloid and Protofibril Formation by the ABri Peptide of Familial British Dementia. Journal of Molecular Biology 333:5, pages 1003-1023.
Crossref
J. I. Kourie, B. L. Kenna, D. Tew, M. F. Jobling, C. C. Curtain, C. L. Masters, K. J. Barnham & R. Cappai. (2003) Copper Modulation of Ion Channels of PrP[106–126] Mutant Prion Peptide Fragments. Journal of Membrane Biology 193:1, pages 35-45.
Crossref
Math P. Cuajungco & Kyle Y. Fagét. (2003) Zinc takes the center stage: its paradoxical role in Alzheimer’s disease. Brain Research Reviews 41:1, pages 44-56.
Crossref
Nelson Arispe & Michael Doh. (2002) Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AβP (1–40) and (1–42) peptides. The FASEB Journal 16:12, pages 1526-1536.
Crossref
Joseph I Kourie & Christine L Henry. (2002) Ion channel formation and membrane‐linked pathologies of misfolded hydrophobic proteins: The role of dangerous unchaperoned molecules. Clinical and Experimental Pharmacology and Physiology 29:9, pages 741-753.
Crossref
George Lee, Harvey B Pollard & Nelson Arispe. (2002) Annexin 5 and apolipoprotein E2 protect against Alzheimer’s amyloid-β-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site. Peptides 23:7, pages 1249-1263.
Crossref
Joseph I. Kourie, Peter V. Farrelly & Christine L. Henry. (2001) Channel activity of deamidated isoforms of prion protein fragment 106-126 in planar lipid bilayers. Journal of Neuroscience Research 66:2, pages 214-220.
Crossref
Joseph I Kourie. (2001) Mechanisms of prion-induced modifications in membrane transport properties: Implications for signal transduction and neurotoxicity. Chemico-Biological Interactions 138:1, pages 1-26.
Crossref

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