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Amyloid
The Journal of Protein Folding Disorders
Volume 18, 2011 - Issue 3
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Original Article

The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide

Anat Frydman-MaromDepartment of Molecular Microbiology & Biotechnology, Tel-Aviv University, Tel-Aviv 69978, Israel
,
Ronit Shaltiel-KaryoDepartment of Molecular Microbiology & Biotechnology, Tel-Aviv University, Tel-Aviv 69978, Israel
,
Sari MosheDepartment of Molecular Microbiology & Biotechnology, Tel-Aviv University, Tel-Aviv 69978, Israel
&
Ehud GazitDepartment of Molecular Microbiology & Biotechnology, Tel-Aviv University, Tel-Aviv 69978, IsraelCorrespondence[email protected]
Pages 119-127 | Received 06 Oct 2010, Accepted 18 Apr 2011, Published online: 09 Jun 2011

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Sara Bohman & Gunilla T. Westermark. (2012) Extensive amyloid formation in transplanted microencapsulated mouse and human islets. Amyloid 19:2, pages 87-93.
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Articles from other publishers (30)

Zaida L. Almeida & Rui M. M. Brito. (2022) Amyloid Disassembly: What Can We Learn from Chaperones?. Biomedicines 10:12, pages 3276.
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Issam Hmila, Indulekha P. Sudhakaran, Simona S. Ghanem, Nishant N. Vaikath, Ilaria Poggiolini, Houari Abdesselem & Omar M. A. El-Agnaf. (2022) Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils. ACS Chemical Neuroscience 13:23, pages 3330-3341.
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Asra Nasir Khan & Rizwan Hasan Khan. (2022) Protein misfolding and related human diseases: A comprehensive review of toxicity, proteins involved, and current therapeutic strategies. International Journal of Biological Macromolecules 223, pages 143-160.
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Karin Taş, Beatrice Dalla Volta, Christina Lindner, Omar El Bounkari, Kathleen Hille, Yuan Tian, Xènia Puig-Bosch, Markus Ballmann, Simon Hornung, Martin Ortner, Sophia Prem, Laura Meier, Gerhard Rammes, Martin Haslbeck, Christian Weber, Remco T. A. Megens, Jürgen Bernhagen & Aphrodite Kapurniotu. (2022) Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Nature Communications 13:1.
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Angelo Santoro, Manuela Grimaldi, Michela Buonocore, Ilaria Stillitano, Antonio Gloria, Matteo Santin, Fabrizio Bobba, Matilde Sublimi Saponetti, Elena Ciaglia & Anna Maria D'Ursi. (2022) New Aβ(1–42) ligands from anti-amyloid antibodies: Design, synthesis, and structural interaction. European Journal of Medicinal Chemistry 237, pages 114400.
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Mouli Konar, Debasis Ghosh, Sourav Samanta & Thimmaiah Govindaraju. (2022) Combating amyloid-induced cellular toxicity and stiffness by designer peptidomimetics. RSC Chemical Biology 3:2, pages 220-226.
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Kimberly Jia Yi Low, Anandalakshmi Venkatraman, Jodhbir S. Mehta & Konstantin Pervushin. (2022) Molecular mechanisms of amyloid disaggregation. Journal of Advanced Research 36, pages 113-132.
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Wenjia Lou, Samuel D. Stimple, Alec A. Desai, Emily K. Makowski, Sibel Kalyoncu, Jesper E. Mogensen, Lotte T. Spang, Désirée J. Asgreen, Arne Staby, Karen Duus, Jan Amstrup, Yulei Zhang & Peter M. Tessier. (2020) Directed evolution of conformation‐specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations. Biotechnology and Bioengineering 118:2, pages 797-808.
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Oscar Palomino-Hernandez, Fiamma A. Buratti, Pamela S. Sacco, Giulia Rossetti, Paolo Carloni & Claudio O. Fernandez. (2020) Role of Tyr-39 for the Structural Features of α-Synuclein and for the Interaction with a Strong Modulator of Its Amyloid Assembly. International Journal of Molecular Sciences 21:14, pages 5061.
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John R. Horsley, Blagojce Jovcevski, Kate L. Wegener, Jingxian Yu, Tara L. Pukala & Andrew D. Abell. (2020) Rationally designed peptide-based inhibitor of Aβ42 fibril formation and toxicity: a potential therapeutic strategy for Alzheimer's disease. Biochemical Journal 477:11, pages 2039-2054.
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Kolla Rajasekhar, Sourav Samanta, Vardhaman Bagoband, N. Arul Murugan & Thimmaiah Govindaraju. (2020) Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity. iScience 23:4, pages 101005.
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Valentina Armiento, Anna Spanopoulou & Aphrodite Kapurniotu. (2019) Peptide‐Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration. Angewandte Chemie International Edition 59:9, pages 3372-3384.
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Valentina Armiento, Anna Spanopoulou & Aphrodite Kapurniotu. (2019) Peptid‐basierte molekulare Strategien zum Einsatz bei Proteinfehlfaltung, Proteinaggregation und Zelldegeneration. Angewandte Chemie 132:9, pages 3396-3409.
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Nazareno González, Iñaki Gentile, Hugo A. Garro, Susana Delgado-Ocaña, Carla F. Ramunno, Fiamma A. Buratti, Christian Griesinger & Claudio O. Fernández. (2019) Metal coordination and peripheral substitution modulate the activity of cyclic tetrapyrroles on αS aggregation: a structural and cell-based study. JBIC Journal of Biological Inorganic Chemistry 24:8, pages 1269-1278.
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Xiaoxi Ren, Yun Zhao, Fenqin Xue, Yan Zheng, Haixia Huang, Wei Wang, Yongchang Chang, Hui Yang & Jianliang Zhang. (2019) Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson’s Disease Model. Molecular Therapy - Nucleic Acids 17, pages 726-740.
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Yuan Zheng, Jing Qu, Fenqin Xue, Yan Zheng, Bo Yang, Yongchang Chang, Hui Yang & Jianliang Zhang. (2018) Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation. Molecular Therapy - Nucleic Acids 11, pages 228-242.
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Ariel A. Valiente-Gabioud, Dietmar Riedel, Tiago F. Outeiro, Mauricio A. Menacho-Márquez, Christian Griesinger & Claudio O. Fernández. (2018) Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation. Biophysical Journal 114:5, pages 1036-1045.
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Therese W. Herling, Aviad Levin, Kadi L. Saar, Christopher M. Dobson & Tuomas P. J. Knowles. (2018) Microfluidic approaches for probing amyloid assembly and behaviour. Lab on a Chip 18:7, pages 999-1016.
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Soyoung Yoon, Soohyun Kim, Hana Im & Kyunghee Lee. (2017) Regulation of Amyloid Fibril Formation from Human Islet Amyloid Polypeptide by a Ligand Binding to the Fusion of FK506-binding Protein and the Insertion-in-Flap Domain. Bulletin of the Korean Chemical Society 38:11, pages 1293-1298.
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Sayanti Brahmachari, Ashim Paul, Daniel Segal & Ehud Gazit. (2017) Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules. Future Medicinal Chemistry 9:8, pages 797-810.
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Adam A. Profit, Jayson Vedad & Ruel Z. B. Desamero. (2017) Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation. Bioconjugate Chemistry 28:2, pages 666-677.
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Kadi-Liis Saar, Emma V. Yates, Thomas Müller, Séverine Saunier, Christopher M. Dobson & Tuomas P.J. Knowles. (2016) Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform. Biophysical Journal 110:3, pages 555-560.
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Ann-Louise Bergström, Pekka Kallunki & Karina Fog. (2016) Development of Passive Immunotherapies for Synucleinopathies. Movement Disorders 31:2, pages 203-213.
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Jessica S. FortinMarie-Odile Benoit-Biancamano. (2016) Inhibition of islet amyloid polypeptide aggregation and associated cytotoxicity by nonsteroidal anti-inflammatory drugs. Canadian Journal of Physiology and Pharmacology 94:1, pages 35-48.
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Christopher G. Parsons, Maarten Ruitenberg, Christine E. Freitag, Kamila Sroka-Saidi, Hermann Russ & Gerhard Rammes. (2015) MRZ-99030 – A novel modulator of Aβ aggregation: I – Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD). Neuropharmacology 92, pages 158-169.
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Gerhard Rammes, Andreas Gravius, Maarten Ruitenberg, Nico Wegener, Caroline Chambon, Kamila Sroka-Saidi, Ross Jeggo, Lydia Staniaszek, Dave Spanswick, Eugene O'Hare, Philip Palmer, Eun-Mee Kim, Wolfgang Bywalez, Veronica Egger & Christopher G. Parsons. (2015) MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice. Neuropharmacology 92, pages 170-182.
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R. Pouplana & J. M. Campanera. (2015) Energetic contributions of residues to the formation of early amyloid-β oligomers. Physical Chemistry Chemical Physics 17:4, pages 2823-2837.
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Ramón Cacabelos, Pablo Cacabelos, Clara Torrellas, Iván Tellado & Juan C. Carril. 2014. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 323 556 .
Mikael Trellet, Adrien S. J. Melquiond & Alexandre M. J. J. Bonvin. (2013) A Unified Conformational Selection and Induced Fit Approach to Protein-Peptide Docking. PLoS ONE 8:3, pages e58769.
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Nikolai Lorenzen, Erich E. Wanker & Daniel Otzen. 2013. Amyloid Fibrils and Prefibrillar Aggregates. Amyloid Fibrils and Prefibrillar Aggregates 345 372 .

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