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Amyloid
The Journal of Protein Folding Disorders
Volume 5, 1998 - Issue 3
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Original Article

Analysis of x-ray diffraction patterns from amyloid of biopsied vitreous humor and kidney of transthyretin (TTR) Met30 familial amyloidotic polyneuropathy (FAP) patients: axially arrayed TTR monomers constitute the protofilament

Hideyo Inouye Department of Biology, Boston College, Chestnut Hill, MA, USACorrespondence[email protected]@bc.edu
,
Francisco S. Domingue Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal
,
Ana M. Damas Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
,
Maria J. Saraiva Instituto de Ciencias Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal
,
Erik Lundgren Department of Cell Molecular Biology, University of Ume, Sweden
,
Ola Sandgren Department of Ophthalmology, University of Umei, Sweden
&
Daniel A. Kirschner Department of Biology, Boston College, Chestnut Hill, MA, USA
 show all
Pages 163-174 | Received 28 Apr 1998, Accepted 07 Jul 1998, Published online: 06 Jul 2009

Citations (34)

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Yoshiki Sekijima, Takahiko Tokuda, Fuyuki Kametani, Kikuko Tanaka, Kei Maruyama & Shu-Ichi Ikeda. (2001) Serum transthyretin monomer in patients with familial amyloid polyneuropathy. Amyloid 8:4, pages 257-262.
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Miguel Munar-Qués, Luis Salvá-Ladaria, Pilar Mulet-perera, Manuel Solé, Francisco R. López-Andreu & Maria J.M. Saraiva. (2000) Vitreous amyloidosis after liver transplantation in patients with familial amyloid polyneuropathy: Ocular synthesis of mutant transthyretin. Amyloid 7:4, pages 266-269.
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Articles from other publishers (32)

Gerald Stubbs & Jan Stöhr. (2017) Structural Biology of PrP Prions. Cold Spring Harbor Perspectives in Medicine 7:6, pages a024455.
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Minna Groenning, Raul I. Campos, Daniel Hirschberg, Per Hammarström & Bente Vestergaard. (2015) Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils. Scientific Reports 5:1.
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Takamura Nagasaka. 2012. Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease. Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease 565 607 .
Maria João Saraiva & Isabel Santos Cardoso. 2012. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases 407 432 .
Ricardo H. Pires, Maria J. Saraiva, Ana M. Damas & Miklós S. Z. Kellermayer. (2011) Structure and assembly–disassembly properties of wild‐type transthyretin amyloid protofibrils observed with atomic force microscopy. Journal of Molecular Recognition 24:3, pages 467-476.
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Simon E. KolstoeSteve P. Wood. (2010) Drug targets for amyloidosis. Biochemical Society Transactions 38:2, pages 466-470.
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Steve P. Wood & Alun R. Coker. 2008. Protein Science Encyclopedia. Protein Science Encyclopedia 189 209 .
XiaoYang Luo, Hideyo Inouye, Abby A.R. Gross, Marla M. Hidalgo, Deepak Sharma, Daniel Lee, Robin L. Avila, Mario Salmona & Daniel A. Kirschner. (2007) Cytoplasmic Domain of Zebrafish Myelin Protein Zero: Adhesive Role Depends on β-Conformation. Biophysical Journal 93:10, pages 3515-3528.
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Lu?s Gales, Maria J. Saraiva & Ana M. Damas. (2007) Structural basis for the protective role of sulfite against transthyretin amyloid formation. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1774:1, pages 59-64.
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Hideyo Inouye, Deepak Sharma, Warren J. Goux & Daniel A. Kirschner. (2006) Structure of Core Domain of Fibril-Forming PHF/Tau Fragments. Biophysical Journal 90:5, pages 1774-1789.
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Hideyo Inouye, Deepak Sharma & Daniel A. Kirschner. 2006. Misbehaving Proteins. Misbehaving Proteins 167 191 .
O. Sumner Makin & Louise C. Serpell. (2005) Structures for amyloid fibrils. The FEBS Journal 272:23, pages 5950-5961.
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Takayuki Kurosawa, Shuichi Igarashi, Masatoyo Nishizawa & Osamu Onodera. (2005) Selective silencing of a mutant transthyretin allele by small interfering RNAs. Biochemical and Biophysical Research Communications 337:3, pages 1012-1018.
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S. P. Wood & A. R. Coker. 2005. Amyloid Proteins. Amyloid Proteins 189 209 .
Ana Margarida Damas & Maria João Saraiva. 2005. Amyloid Proteins. Amyloid Proteins 571 588 .
Luís GALES, Sandra MACEDO-RIBEIRO, Gemma ARSEQUELL, Gregorio VALENCIA, Maria João SARAIVA & Ana Margarida DAMAS. (2005) Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor. Biochemical Journal 388:2, pages 615-621.
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Lisa Craig, Michael E. Pique & John A. Tainer. (2004) Type IV pilus structure and bacterial pathogenicity. Nature Reviews Microbiology 2:5, pages 363-378.
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Jeremy P. Bond, Sean P. Deverin, Hideyo Inouye, Omar M.A. El-Agnaf, Martha M. Teeter & Daniel A. Kirschner. (2003) Assemblies of Alzheimer’s peptides Aβ25–35 and Aβ31–35: reverse-turn conformation and side-chain interactions revealed by X-ray diffraction. Journal of Structural Biology 141:2, pages 156-170.
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I Cardoso, C.S Goldsbury, S.A M?ller, V Olivieri, S Wirtz, A.M Damas, U Aebi & M.J Saraiva. (2002) Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils 1 1Edited by M. Moody. Journal of Molecular Biology 317:5, pages 683-695.
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Mónica Mendes Sousa, Isabel Cardoso, Rui Fernandes, António Guimarães & Maria João Saraiva. (2001) Deposition of Transthyretin in Early Stages of Familial Amyloidotic Polyneuropathy. The American Journal of Pathology 159:6, pages 1993-2000.
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Alexandre Quintas, Daniela C. Vaz, Isabel Cardoso, Maria João M. Saraiva & Rui M.M. Brito. (2001) Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants. Journal of Biological Chemistry 276:29, pages 27207-27213.
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Maria João Mascarenhas Saraiva. (2001) Transthyretin amyloidosis: a tale of weak interactions. FEBS Letters 498:2-3, pages 201-203.
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Maria Jo�o Mascarenhas Saraiva. (2001) Transthyretin mutations in hyperthyroxinemia and amyloid diseases. Human Mutation 17:6, pages 493-503.
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Maria Paula Sebastião, Victor Lamzin, Maria João Saraiva & Ana Margarida Damas. (2001) Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution. Journal of Molecular Biology 306:4, pages 733-744.
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Aaron K. Chamberlain, Cait E. MacPhee, Jesús Zurdo, Ludmilla A. Morozova-Roche, H. Allen O. Hill, Christopher M. Dobson & Jason J. Davis. (2000) Ultrastructural Organization of Amyloid Fibrils byAtomic Force Microscopy. Biophysical Journal 79:6, pages 3282-3293.
Crossref
Clara Redondo, Ana Margarida Damas, Anders Olofsson, Erik Lundgren & Maria João M. Saraiva. (2000) Search for intermediate structures in transthyretin fibrillogenesis: soluble tetrameric Tyr78Phe TTR expresses a specific epitope present only in amyloid fibrils. Journal of Molecular Biology 304:3, pages 461-470.
Crossref
Andreas Hörnberg, Therese Eneqvist, Anders Olofsson, Erik Lundgren & A.Elisabeth Sauer-Eriksson. (2000) A comparative analysis of 23 structures of the amyloidogenic protein transthyretin. Journal of Molecular Biology 302:3, pages 649-669.
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Amareth Lim, Alexander M. Makhov, Jeremy Bond, Hideyo Inouye, Lawreen H. Connors, Jack D. Griffith, Bruce W. Erickson, Daniel A. Kirschner & Catherine E. Costello. (2000) Betabellins 15D and 16D, de Novo Designed ?-Sandwich Proteins That Have Amyloidogenic Properties. Journal of Structural Biology 130:2-3, pages 363-370.
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Gregor Damaschun, Hilde Damaschun, Heinz Fabian, Klaus Gast, Reinhard Kr�ber, Martin Wieske & Dietrich Zirwer. (2000) Conversion of yeast phosphoglycerate kinase into amyloid-like structure. Proteins: Structure, Function, and Genetics 39:3, pages 204-211.
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Jean-Christophe Rochet & Peter T LansburyJrJr. (2000) Amyloid fibrillogenesis: themes and variations. Current Opinion in Structural Biology 10:1, pages 60-68.
Crossref
Alexandre Quintas, Maria João M. Saraiva & Rui M.M. Brito. (1999) The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution. Journal of Biological Chemistry 274:46, pages 32943-32949.
Crossref
Gundars Goldsteins, Håkan Persson, Karin Andersson, Anders Olofsson, Ingrid Dacklin, Åsa Edvinsson, Maria João Saraiva & Erik Lundgren. (1999) Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proceedings of the National Academy of Sciences 96:6, pages 3108-3113.
Crossref

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