Publication Cover
Amyloid
The Journal of Protein Folding Disorders
Volume 5, 1998 - Issue 3
91
Views
39
CrossRef citations to date
0
Altmetric
Original Article

Tertiary structures of amyloidogenic and non-amyloidogenic transthyretin variants: new model for amyloid fibril formation

, &
Pages 175-187 | Received 07 Jul 1997, Accepted 06 May 1998, Published online: 06 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Michael Rosenzweig, Martha Skinner, Tatiana Prokaeva, Roger Théberge, Catherine Costello, Brian M. Drachman & Lawreen H. Connors. (2007) A new transthyretin variant (Glu61Gly) associated with cardiomyopathy. Amyloid 14:1, pages 65-71.
Read now
Amareth Lim, Tatiana Prokaeva, Lawreen H. Connors, Rodney H. Falk, Martha Skinner & Catherine E. Costello. (2002) Identification of a novel transthyretin Thr59Lys/Arg104His. A case of compound heterozygosity in a Chinese patient diagnosed with familial transthyretin amyloidosis. Amyloid 9:2, pages 134-140.
Read now

Articles from other publishers (37)

Nataliya V. Slovesnova, Artem S. Minin, Anna V. Belousova, Aleksey A. Ustyugov, Kirill D. Chaprov, Alexey P. Krinochkin, Maria I. Valieva, Yaroslav K. Shtaitz, Ekaterina S. Starnovskaya, Igor L. Nikonov, Anton N. Tsmokalyuk, Grigory A. Kim, Sougata Santra, Dmitry S. Kopchuk, Emiliya V. Nosova & Grigory V. Zyryanov. (2022) New TEMPO–Appended 2,2′-Bipyridine-Based Eu(III), Tb(III), Gd(III) and Sm(III) Complexes: Synthesis, Photophysical Studies and Testing Photoluminescence-Based Bioimaging Abilities. Molecules 27:23, pages 8414.
Crossref
Julian Hartmann & Martin Zacharias. (2022) Analysis of amyloidogenic transthyretin mutations using continuum solvent free energy calculations. Proteins: Structure, Function, and Bioinformatics 90:12, pages 2080-2090.
Crossref
Filipa Bezerra, Christoph Niemietz, Hartmut H. J. Schmidt, Andree Zibert, Shuling Guo, Brett P. Monia, Paula Gonçalves, Maria João Saraiva & Maria Rosário Almeida. (2021) In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis. International Journal of Molecular Sciences 22:17, pages 9488.
Crossref
Filipa Bezerra, Maria João Saraiva & Maria Rosário Almeida. (2020) Modulation of the Mechanisms Driving Transthyretin Amyloidosis. Frontiers in Molecular Neuroscience 13.
Crossref
Celia M. Torres-Arancivia, Deborah Chang, William E. Hackett, Joseph Zaia & Lawreen H. Connors. (2020) Glycosylation of Serum Clusterin in Wild-Type Transthyretin-Associated (ATTRwt) Amyloidosis: A Study of Disease-Associated Compositional Features Using Mass Spectrometry Analyses. Biochemistry 59:45, pages 4367-4378.
Crossref
Katsuhiro Kusaka, Takeshi Yokoyama, Taro Yamada, Naomine Yano, Ichiro Tanaka & Mineyuki Mizuguchi. (2020) Neutron diffraction experiment with the Y116S variant of transthyretin using iBIX at J-PARC: application of a new integration method. Acta Crystallographica Section D Structural Biology 76:11, pages 1050-1056.
Crossref
Valentina Loconte, Ilaria Menozzi, Alberto Ferrari, Claudia Folli, Bruno P. Imbimbo, Giuseppe Zanotti & Rodolfo Berni. (2019) Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. Journal of Structural Biology 208:2, pages 165-173.
Crossref
Hannah A. Davies, Daniel J. Rigden, Marie M. Phelan & Jillian Madine. (2017) Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics. Scientific Reports 7:1.
Crossref
Lorena Saelices, Lisa M. Johnson, Wilson Y. Liang, Michael R. Sawaya, Duilio Cascio, Piotr Ruchala, Julian Whitelegge, Lin Jiang, Roland Riek & David S. Eisenberg. (2015) Uncovering the Mechanism of Aggregation of Human Transthyretin. Journal of Biological Chemistry 290:48, pages 28932-28943.
Crossref
Colleen Fearns, Stephen Connelly, Evan T. Powers & Jeffery W. Kelly. 2013. Amyloid Fibrils and Prefibrillar Aggregates. Amyloid Fibrils and Prefibrillar Aggregates 373 394 .
Steven M. Johnson, Stephen Connelly, Colleen Fearns, Evan T. Powers & Jeffery W. Kelly. (2012) The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug. Journal of Molecular Biology 421:2-3, pages 185-203.
Crossref
Xue Xu, Xia Wang, Zhentao Xiao, Yan Li & Yonghua Wang. (2012) Probing the structural and functional link between mutation- and pH-dependent hydration dynamics and amyloidosis of transthyretin. Soft Matter 8:2, pages 324-336.
Crossref
Takamura Nagasaka. 2012. Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease. Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease 565 607 .
Jarrod B. French & Steven E. Ealick. (2011) Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae . Acta Crystallographica Section D Biological Crystallography 67:8, pages 671-677.
Crossref
Laura Cendron, Antonio Trovato, Flavio Seno, Claudia Folli, Beatrice Alfieri, Giuseppe Zanotti & Rodolfo Berni. (2009) Amyloidogenic Potential of Transthyretin Variants. Journal of Biological Chemistry 284:38, pages 25832-25841.
Crossref
A. Bersano, R. Del Bo, E. Ballabio, C. Cinnante, S. Lanfranconi, G.P. Comi, P. Baron, N. Bresolin & L. Candelise. (2009) Transthyretin asn90 variant: Amyloidogenic or non-amyloidogenic role. Journal of the Neurological Sciences 284:1-2, pages 113-115.
Crossref
Vivian Cody & Andrzej Wojtczak. 2009. Recent Advances in Transthyretin Evolution, Structure and Biological Functions. Recent Advances in Transthyretin Evolution, Structure and Biological Functions 1 21 .
Giuseppe Zanotti, Claudia Folli, Laura Cendron, Beatrice Alfieri, Sonia K. Nishida, Francesca Gliubich, Nicola Pasquato, Alessandro Negro & Rodolfo Berni. (2008) Structural and mutational analyses of protein–protein interactions between transthyretin and retinol‐binding protein. The FEBS Journal 275:23, pages 5841-5854.
Crossref
Francesca Lavatelli, David H. Perlman, Brian Spencer, Tatiana Prokaeva, Mark E. McComb, Roger Théberge, Lawreen H. Connors, Vittorio Bellotti, David C. Seldin, Giampaolo Merlini, Martha Skinner & Catherine E. Costello. (2008) Amyloidogenic and Associated Proteins in Systemic Amyloidosis Proteome of Adipose Tissue. Molecular & Cellular Proteomics 7:8, pages 1570-1583.
Crossref
Mineyuki Mizuguchi, Ayumi Hayashi, Makoto Takeuchi, Mizuki Dobashi, Yoshihiro Mori, Hiroyuki Shinoda, Tomoyasu Aizawa, Makoto Demura & Keiichi Kawano. (2008) Unfolding and aggregation of transthyretin by the truncation of 50 N‐terminal amino acids. Proteins: Structure, Function, and Bioinformatics 72:1, pages 261-269.
Crossref
Joy G. Ghosh, Scott A. Houck & John I. Clark. (2008) Interactive sequences in the molecular chaperone, human αB crystallin modulate the fibrillation of amyloidogenic proteins. The International Journal of Biochemistry & Cell Biology 40:5, pages 954-967.
Crossref
Houfang Wang, Yanhui Tang & Ming Lei. (2007) Models for binding cooperativities of inhibitors with transthyretin. Archives of Biochemistry and Biophysics 466:1, pages 85-97.
Crossref
Minna Groenning, Lars Olsen, Marco van de Weert, James M. Flink, Sven Frokjaer & Flemming S. Jørgensen. (2007) Study on the binding of Thioflavin T to β-sheet-rich and non-β-sheet cavities. Journal of Structural Biology 158:3, pages 358-369.
Crossref
Xu Hou, Marie‐Isabel Aguilar & David H. Small. (2007) Transthyretin and familial amyloidotic polyneuropathy. The FEBS Journal 274:7, pages 1637-1650.
Crossref
Joakim Bergström, Ulla Engström, Taro Yamashita, Yukio Ando & Per Westermark. (2006) Surface exposed epitopes and structural heterogeneity of in vivo formed transthyretin amyloid fibrils. Biochemical and Biophysical Research Communications 348:2, pages 532-539.
Crossref
Martino Calamai, Fabrizio Chiti & Christopher M. Dobson. (2005) Amyloid Fibril Formation Can Proceed from Different Conformations of a Partially Unfolded Protein. Biophysical Journal 89:6, pages 4201-4210.
Crossref
Ana Margarida Damas & Maria João Saraiva. 2005. Amyloid Proteins. Amyloid Proteins 571 588 .
R. Luke Wiseman, Steven M. Johnson, Matthew S. Kelker, Ted Foss, Ian A. Wilson & Jeffery W. Kelly. (2005) Kinetic Stabilization of an Oligomeric Protein by a Single Ligand Binding Event. Journal of the American Chemical Society 127:15, pages 5540-5551.
Crossref
Andreas Hörnberg, Anders Olofsson, Therese Eneqvist, Erik Lundgren & A.Elisabeth Sauer-Eriksson. (2004) The β-strand D of transthyretin trapped in two discrete conformations. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1700:1, pages 93-104.
Crossref
Márcia Almeida Liz, Carlos José Faro, Maria João Saraiva & Mónica Mendes Sousa. (2004) Transthyretin, a New Cryptic Protease. Journal of Biological Chemistry 279:20, pages 21431-21438.
Crossref
Amareth Lim, Shantanu Sengupta, Mark E. McComb, Roger Théberge, William G. Wilson, Catherine E. Costello & Donald W. Jacobsen. (2003) In Vitro and in Vivo Interactions of Homocysteine with Human Plasma Transthyretin. Journal of Biological Chemistry 278:50, pages 49707-49713.
Crossref
Merrill D Benson. (2003) The hereditary amyloidoses. Best Practice & Research Clinical Rheumatology 17:6, pages 909-927.
Crossref
George Moraitakis & Julia M. Goodfellow. (2003) Simulations of Human Lysozyme: Probing the Conformations Triggering Amyloidosis. Biophysical Journal 84:4, pages 2149-2158.
Crossref
J. S. Wall, M. Schell, R. Hrncic, F. J. Stevens & A. Solomon. 2003. Monoclonal Gammopathies and the Kidney. Monoclonal Gammopathies and the Kidney 203 214 .
Amareth Lim, Tatiana Prokaeva, Mark E. McComb, Peter B. O'Connor, Roger Théberge, Lawreen H. Connors, Martha Skinner & Catherine E. Costello. (2002) Characterization of Transthyretin Variants in Familial Transthyretin Amyloidosis by Mass Spectrometric Peptide Mapping and DNA Sequence Analysis. Analytical Chemistry 74:4, pages 741-751.
Crossref
Andreas Hörnberg, Therese Eneqvist, Anders Olofsson, Erik Lundgren & A.Elisabeth Sauer-Eriksson. (2000) A comparative analysis of 23 structures of the amyloidogenic protein transthyretin. Journal of Molecular Biology 302:3, pages 649-669.
Crossref
Gundars Goldsteins, Håkan Persson, Karin Andersson, Anders Olofsson, Ingrid Dacklin, Åsa Edvinsson, Maria João Saraiva & Erik Lundgren. (1999) Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proceedings of the National Academy of Sciences 96:6, pages 3108-3113.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.