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Review Article

Clara cell protein (CC16): characteristics and potential applications as biomarker of lung toxicity

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Pages 3-8 | Received 20 Oct 1995, Accepted 24 Oct 1995, Published online: 27 Sep 2008

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Read on this site (7)

Lin Zhao, Yifang Zhu, Zhangjian Chen, Huadong Xu, Jingwen Zhou, Shichuan Tang, Zhizhen Xu, Fanling Kong, Xinwei Li, Yifei Zhang, Xianzuo Li, Ji Zhang & Guang Jia. (2018) Cardiopulmonary effects induced by occupational exposure to titanium dioxide nanoparticles. Nanotoxicology 12:2, pages 169-184.
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Nahida Haddam, Sekkal Samira, Xavier Dumont, Abdesselem Taleb, Vincent Haufroid, Dominique Lison & Alfred Bernard. (2009) Lung epithelium injury biomarkers in workers exposed to sulphur dioxide in a non-ferrous smelter. Biomarkers 14:5, pages 292-298.
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Tadeusz Halatek, Halina Sinczuk-Walczak & Konrad Rydzynski. (2008) Early neurotoxic effects of inhalation exposure to aluminum and/or manganese assessed by serum levels of phospholipid-binding Clara cells protein. Journal of Environmental Science and Health, Part A 43:2, pages 118-124.
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Alfred Bernard. (2008) Critical review of Clara cell protein: sound science?. Biomarkers 13:3, pages 237-243.
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Karine Berthoin, Fabrice Broeckaert, Marjorie Robin, Vincent Haufroid, Claire De Burbure & Alfred Bernard. (2004) Serum pneumoproteins and biomarkers of exposure to urban air pollution: a cross-sectional comparison of policemen and foresters. Biomarkers 9:4-5, pages 341-352.
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Martin Petrek, Cedric Hermans, Vítězslav Kolek, Jarmila Fialová & Alfred Bernard. (2002) Clara cell protein (CC16) in serum and bronchoalveolar lavage fluid of subjects exposed to asbestos. Biomarkers 7:1, pages 58-67.
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MARCO DELLOMO, CEDRIC HERMANS, GIACOMO MUZI, VINCENT HAUFROID, ALFRED BERNARD, PATRIZIA CARRIERI & GIUSEPPE ABBRITTI. (2000) Serum Clara cell protein (CC16) in healthy young smokers. Biomarkers 5:2, pages 158-164.
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Articles from other publishers (28)

Natalie Iannuzo, Alane Blythe C. Dy, Stefano Guerra, Paul R. Langlais & Julie G. Ledford. (2023) The Impact of CC16 on Pulmonary Epithelial-Driven Host Responses during Mycoplasma pneumoniae Infection in Mouse Tracheal Epithelial Cells. Cells 12:15, pages 1984.
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Sarah J.D. Nauwelaerts, Nina Van Goethem, Koen De Cremer, Natalia Bustos Sierra, Jordy Vercauteren, Christophe Stroobants, Alfred Bernard, Tim Nawrot, Nancy H.C. Roosens & Sigrid C.J. De Keersmaecker. (2023) Noninvasive integrative approach applied to children in the context of recent air pollution exposure demonstrates association between fractional exhaled nitric oxide (FeNO) and urinary CC16. Environmental Research 216, pages 114441.
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Sarah J. D. Nauwelaerts, Nancy H. C. Roosens, Alfred Bernard, Sigrid C. J. De Keersmaecker & Koen De Cremer. (2021) Development of a multiplex mass spectrometry method for simultaneous quantification of urinary proteins related to respiratory health. Scientific Reports 11:1.
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Yishuo Gu, Wei He, Yanhua Wang, Juan Chen, Hongfei Wang, Panjun Gao, Siwen Yang, Xiaojun Zhu, Wenjun Ma & Tao Li. (2020) Respiratory effects induced by occupational exposure to refractory ceramic fibers. Journal of Applied Toxicology 41:3, pages 421-441.
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Joana Barbosa, Juliana Faria, Fernanda Garcez, Sandra Leal, Luís Pedro Afonso, Ana Vanessa Nascimento, Roxana Moreira, Frederico C. Pereira, Odília Queirós, Félix Carvalho & Ricardo Jorge Dinis-Oliveira. (2021) Repeated Administration of Clinically Relevant Doses of the Prescription Opioids Tramadol and Tapentadol Causes Lung, Cardiac, and Brain Toxicity in Wistar Rats. Pharmaceuticals 14:2, pages 97.
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Ege Gulec Balbay, Ozlem Ataoglu, Merve Ercelik, Ibrahim Ethem Sahin, Ozlem Admis & Peri Meram Arbak. (2020) Serum Clara cell secretory protein (CC-16) in non-smoking patients with obstructive sleep apnea. Sleep and Breathing 24:4, pages 1607-1612.
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Yanhua Wang, Huawei Duan, Tao Meng, Meili Shen, Qianpeng Ji, Jie Xing, Qingrong Wang, Ting Wang, Yong Niu, Tao Yu, Zhong Liu, Hongbing Jia, Yuliang Zhan, Wen Chen, Zhihu Zhang, Wenge Su, Yufei Dai, Xuchun Zhang & Yuxin Zheng. (2018) Reduced serum club cell protein as a pulmonary damage marker for chronic fine particulate matter exposure in Chinese population. Environment International 112, pages 207-217.
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Katerina Kaidoglou, Maria Bousnaki, Constantini Samara & Elpida-Niki Emmanouil-Nikoloussi. (2017) Secretoglobin 1A1 (SCGB1A1) protein expressed immunohistochemically in neonatal mice lung Club cells after exposure at heavy traffic sites in Northern Greece. Reproductive Toxicology 72, pages 24.
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Sultan Ahmed, Evana Akhtar, Adity Roy, Ondine S. von Ehrenstein, Marie Vahter, Yukiko Wagatsuma & Rubhana Raqib. (2017) Arsenic exposure alters lung function and airway inflammation in children: A cohort study in rural Bangladesh. Environment International 101, pages 108-116.
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Kerstin Romberg, Leif Bjermer & Ellen Tufvesson. (2011) Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers. Respiratory Medicine 105:1, pages 31-36.
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Fernando Gil & Antonio F. Hernández. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
John T. Coppens, Laura S. Van Winkle, Kent Pinkerton & Charles G. Plopper. (2007) Distribution of Clara cell secretory protein expression in the tracheobronchial airways of rhesus monkeys. American Journal of Physiology-Lung Cellular and Molecular Physiology 292:5, pages L1155-L1162.
Crossref
John Timbrell. 2005. Metabonomics in Toxicity Assessment. Metabonomics in Toxicity Assessment 27 74 .
Birgitta Json Lagerkvist, Alfred Bernard, Anders Blomberg, Erik Bergstrom, Bertil Forsberg, Karin Holmstrom, Kjell Karp, Nils-Goran Lundstrom, Bo Segerstedt, Mona Svensson & Gunnar Nordberg. (2004) Pulmonary Epithelial Integrity in Children: Relationship to Ambient Ozone Exposure and Swimming Pool Attendance. Environmental Health Perspectives 112:17, pages 1768-1771.
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X.M. Gioldassi, H. Papadimitriou, V. Mikraki & N.K. Karamanos. (2004) Clara cell secretory protein: determination of serum levels by an enzyme immunoassay and its importance as an indicator of bronchial asthma in children. Journal of Pharmaceutical and Biomedical Analysis 34:4, pages 823-826.
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Jefferey L. Burgess, Mark L. Witten, Christopher J. Nanson, Tracy A. Hysong, Duane L. Sherrill, Stuart F. Quan, Richard Gerkin & Alfred M. Bernard. (2003) Serum pneumoproteins: A cross‐sectional comparison of firefighters and police. American Journal of Industrial Medicine 44:3, pages 246-253.
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Shang-Ying Tsai, Hsin-Chien Lee, Chiao-Chicy Chen & Chao-Hsien Lee. (2003) Plasma levels of soluble transferrin receptors and Clara cell protein (CC16) during bipolar mania and subsequent remission. Journal of Psychiatric Research 37:3, pages 229-235.
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C. Hermans, M. Petrek, V. Kolek, B. Weynand, T. Pieters, M. Lambert & A. Bernard. (2001) Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis. European Respiratory Journal 18:3, pages 507-514.
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Fernando Gil & Antonio Pla. (2001) Biomarkers as biological indicators of xenobiotic exposure. Journal of Applied Toxicology 21:4, pages 245-255.
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Michel Aubier & Jacques Lambrozo. (2000) Pollution atmosphérique liée aux transports. Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie 323:7, pages 641-649.
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Ian R DoyleTerence E NicholasAndrew D Bersten. (2002) PARTITIONING LUNG AND PLASMA PROTEINS: CIRCULATING SURFACTANT PROTEINS AS BIOMARKERS OF ALVEOLOCAPILLARY PERMEABILITY ‡ . Clinical and Experimental Pharmacology and Physiology 26:3, pages 185-197.
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CEDRIC HERMANS & ALFRED BERNARD. (1999) Lung Epithelium–specific Proteins. American Journal of Respiratory and Critical Care Medicine 159:2, pages 646-678.
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IAN R. DOYLE, CEDRIC HERMANS, ALFRED BERNARD, TERENCE E. NICHOLAS & ANDREW D. BERSTEN. (1998) Clearance of Clara Cell Secretory Protein 16 (CC16) and Surfactant Proteins A and B from Blood in Acute Respiratory Failure. American Journal of Respiratory and Critical Care Medicine 158:5, pages 1528-1535.
Crossref
John A. Timbrell. (1998) Biomarkers in toxicology. Toxicology 129:1, pages 1-12.
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Cedric Hermans, Osman Aly, Britt-Inger Nyberg, Christer Peterson & Alfred Bernard. (1998) Determinants of Clara cell protein (CC16) concentration in serum: a reassessment with two different immunoassays. Clinica Chimica Acta 272:2, pages 101-110.
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C. HERMANS, O. LESUR, B. WEYNAND, TH. PIETERS, M. LAMBERT & A. BERNARD. (1998) Clara Cell Protein (CC16) in Pleural Fluids. American Journal of Respiratory and Critical Care Medicine 157:3, pages 962-969.
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A. Bernard & C. Hermans. (1997) Biomonitoring of early effects on the kidney or the lung. Science of The Total Environment 199:1-2, pages 205-211.
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A Bernard, C Hermans & G Van Houte. (1997) Transient increase of serum Clara cell protein (CC16) after exposure to smoke.. Occupational and Environmental Medicine 54:1, pages 63-65.
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