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Review Article

Is human exposure to styrene a cause of cytogenetic damage? A re-analysis of the available evidence

Pages 217-225 | Received 16 Nov 1995, Published online: 27 Sep 2008

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E. R. Nestmann, B. S. Lynch & F. Ratpan. (2005) Perspectives On The Genotoxic Risk Of Styrene. Journal of Toxicology and Environmental Health, Part B 8:2, pages 95-107.
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Joshua T. Cohen, Gary Carlson, Gail Charnley, David Coggon, Elizabeth Delzell, John D. Graham, Helmut Greim, Daniel Krewski, Michele Medinsky, Richard Monson, Dennis Paustenbach, Barbara Petersen, Stephen Rappaport, Lorenz Rhomberg, P. Barry Ryan & Kimberly Thompson. (2002) A COMPREHENSIVE EVALUATION OF THE POTENTIAL HEALTH RISKS ASSOCIATED WITH OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO STYRENE. Journal of Toxicology and Environmental Health, Part B 5:1-2, pages 1-263.
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Articles from other publishers (19)

Marcy Banton, Erik Rushton & Anna Steneholm. 2003. Patty's Toxicology. Patty's Toxicology 1 65 .
Solange Costa, Marcello Ceppi, Carla Costa, Susana Silva, Cristiana Pereira, Blanca Laffon, Stefano Bonassi & João Paulo Teixeira. (2016) The cytokinesis-block micronucleus (CBMN) assay in human populations exposed to styrene: A systematic review and meta-analysis. Mutation Research/Reviews in Mutation Research 770, pages 92-105.
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M. Villarini, V. Gianfredi, S. Levorato, S. Vannini, T. Salvatori & M. Moretti. (2016) Occupational exposure to cytostatic/antineoplastic drugs and cytogenetic damage measured using the lymphocyte cytokinesis-block micronucleus assay: A systematic review of the literature and meta-analysis. Mutation Research/Reviews in Mutation Research 770, pages 35-45.
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Sawsan Farouk Helal & Wessam Sabry Elshafy. (2012) Health hazards among workers in plastic industry. Toxicology and Industrial Health 29:9, pages 812-819.
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Fulvio Ricceri, Roger W. Godschalk, Marco Peluso, David H. Phillips, Antonio Agudo, Panagiotis Georgiadis, Steffen Loft, Anne Tjonneland, Ole Raaschou-Nielsen, Domenico Palli, Frederica Perera, Roel Vermeulen, Emanuela Taioli, Radim J. Sram, Armelle Munnia, Fabio Rosa, Alessandra Allione, Giuseppe Matullo & Paolo Vineis. (2010) Bulky DNA Adducts in White Blood Cells: A Pooled Analysis of 3,600 Subjects. Cancer Epidemiology, Biomarkers & Prevention 19:12, pages 3174-3181.
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George Cruzan, James Bus, Marcy Banton, Ralph Gingell & Gary Carlson. (2009) Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: An endpoint/toxic response where data from multiple chemicals converge to support a mode of action. Regulatory Toxicology and Pharmacology 55:2, pages 205-218.
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José Rueff, João P. Teixeira, Luís Silva Santos & Jorge Francisco Gaspar. (2009) Genetic effects and biotoxicity monitoring of occupational styrene exposure. Clinica Chimica Acta 399:1-2, pages 8-23.
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F. Veglia, S. Loft, G. Matullo, M. Peluso, A. Munnia, F. Perera, D. H. Phillips, D. Tang, H. Autrup, O. Raaschou-Nielsen, A. Tjonneland & P. Vineis. (2008) DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis. Carcinogenesis 29:5, pages 932-936.
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Leigh M. Henderson & Günter Speit. (2005) Review of the genotoxicity of styrene in humans. Mutation Research/Reviews in Mutation Research 589:3, pages 158-191.
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João P Teixeira, Jorge Gaspar, Susana Silva, Joana Torres, Susana N Silva, M.Conceição Azevedo, Paula Neves, Blanca Laffon, Josefina Méndez, Carla Gonçalves, Olga Mayan, Peter B Farmer & José Rueff. (2004) Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1. Toxicology 195:2-3, pages 231-242.
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P Vodicka, M Koskinen, R Stetina, P Soucek, L Vodickova, Z Matousu, M Kuricova & K Hemminki. (2003) The role of various biomarkers in the evaluation of styrene genotoxicity. Cancer Detection and Prevention 27:4, pages 275-284.
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Annamaria Buschini, Giuseppe De Palma, Paola Poli, Anna Martino, Carlo Rossi, Paola Mozzoni, Eleonora Scotti, Luca Buzio, Enrico Bergamaschi & Antonio Mutti. (2003) Genetic polymorphism of drug‐metabolizing enzymes and styrene‐induced DNA damage. Environmental and Molecular Mutagenesis 41:4, pages 243-252.
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Blanca Laffon, Eduardo Pásaro & Josefina Méndez. (2002) Evaluation of genotoxic effects in a group of workers exposed to low levels of styrene. Toxicology 171:2-3, pages 175-186.
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Pavel Vodicka, Pavel Soucek, Ad D Tates, Maria Dusinska, Jana Sarmanova, Maria Zamecnikova, Ludmila Vodickova, Mikko Koskinen, Frans A de Zwart, A.T Natarajan & Kari Hemminki. (2001) Association between genetic polymorphisms and biomarkers in styrene-exposed workers. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 482:1-2, pages 89-103.
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Pavel Vodicka, Mikko Koskinen, Ludmila Vodicková, Rudolf Štetina, Petr Šmerák, Ivo Bárta & Kari Hemminki. (2001) DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation. Chemico-Biological Interactions 137:3, pages 213-227.
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Rogelio Tornero-Velez, Suramya Waidyanatha, Hermes Licea Pérez, Siv Osterman-Golkar, Diana Echeverria & Stephen M. Rappaport. (2001) Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 757:1, pages 59-68.
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Gunnar Johanson, Lena Ernstgård, Elisabeth Gullstrand, Agneta Löf, Siv Osterman-Golkar, Carla C. Williams & Susan C.J. Sumner. (2000) Styrene Oxide in Blood, Hemoglobin Adducts, and Urinary Metabolites in Human Volunteers Exposed to 13C8-Styrene Vapors. Toxicology and Applied Pharmacology 168:1, pages 36-49.
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B. Marczynski, M. Peel & X. Baur. (2000) New aspects in genotoxic risk assessment of styrene exposure – a working hypothesis. Medical Hypotheses 54:4, pages 619-623.
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M Somorovská, E Jahnová, J Tulinská, M Zámečnı́ková, J Šarmanová, A Terenová, L Vodičková, A Lı́šková, B Vallová, P Souček, K Hemminki, H Norppa, A Hirvonen, A.D Tates, L Fuortes, M Dušinská & P Vodička. (1999) Biomonitoring of occupational exposure to styrene in a plastics lamination plant. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 428:1-2, pages 255-269.
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