Advanced search
Publication Cover
Biomarkers Volume 19, 2014 - Issue 3
Submit an article Journal homepage
167
Views
23
CrossRef citations to date
0
Altmetric
Research Article

Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans

Mitchell R. McGillDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, KSUSA
,
Mengde CaoDepartment of Medicine, University of Florida Gainesville, FLUSA;Banyan Laboratories, Inc. Alachua, FLUSA
,
Archie SvetlovBanyan Laboratories, Inc. Alachua, FLUSA
,
Matthew R. SharpeDepartment of Internal Medicine, University of Kansas Hospital Kansas City, KSUSA
,
C. David WilliamsDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, KSUSA
,
Steven C. CurryDepartment of Medical Toxicology, Banner Good Samaritan Medical Center Phoenix, AZUSA;Department of Medicine, and Center for Toxicology and Pharmacology Education and Research, University of Arizona College of Medicine Phoenix, AZUSA
,
Anwar FarhoodDepartment of Pathology, St. David’s North Austin Medical Center Austin, TXUSA
,
Hartmut JaeschkeDepartment of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, KSUSACorrespondence[email protected]
[email protected]
&
Stanislav I. SvetlovDepartment of Medicine, University of Florida Gainesville, FLUSA;Banyan Laboratories, Inc. Alachua, FLUSACorrespondence[email protected]
 show all
Pages 222-230 | Received 10 Oct 2013, Accepted 20 Feb 2014, Published online: 06 Mar 2014

Citations (23)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Yvonne Gloor, Domitille Schvartz & Caroline F.Samer. (2019) Old problem, new solutions: biomarker discovery for acetaminophen liver toxicity. Expert Opinion on Drug Metabolism & Toxicology 15:8, pages 659-669.
Read now
Mitchell R. McGill & Hartmut Jaeschke. (2018) Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation. Expert Review of Molecular Diagnostics 18:9, pages 797-807.
Read now
Yvonne Will & James Dykens. (2014) Mitochondrial toxicity assessment in industry – a decade of technology development and insight. Expert Opinion on Drug Metabolism & Toxicology 10:8, pages 1061-1067.
Read now
Mitchell R McGill & Hartmut Jaeschke. (2014) Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients. Expert Opinion on Drug Metabolism & Toxicology 10:7, pages 1005-1017.
Read now

Articles from other publishers (19)

Mitchell R. McGill & Steven C. Curry. (2023) The Evolution of Circulating Biomarkers for Use in Acetaminophen/Paracetamol-Induced Liver Injury in Humans: A Scoping Review. Livers 3:4, pages 569-596.
Crossref
Kodihalli C. Ravindra, Vishal S. Vaidya, Zhenyu Wang, Joel D. Federspiel, Richard Virgen-Slane, Robert A. Everley, Jane I. Grove, Camilla Stephens, Mireia F. Ocana, Mercedes Robles-Díaz, M. Isabel Lucena, Raul J. Andrade, Edmond Atallah, Alexander L. Gerbes, Sabine Weber, Helena Cortez-Pinto, Andrew J. Fowell, Hyder Hussaini, Einar S. Bjornsson, Janisha Patel, Guido Stirnimann, Sumita Verma, Ahmed M. Elsharkawy, William J. H. Griffiths, Craig Hyde, James W. Dear, Guruprasad P. Aithal & Shashi K. Ramaiah. (2023) Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans. Nature Communications 14:1.
Crossref
Sedigheh Molaei, Fatemeh Amiri, Rasoul Salimi, Shirin Ferdowsi & Marzie Bahadori. (2022) Therapeutic effects of mesenchymal stem cells-conditioned medium derived from suspension cultivation or silymarin on liver failure mice. Molecular Biology Reports 49:11, pages 10315-10325.
Crossref
Joel H Vazquez, Stefanie Kennon-McGill, Stephanie D Byrum, Samuel G Mackintosh, Hartmut Jaeschke, D Keith Williams, William M Lee, Jonathan A Dranoff & Mitchell R McGill. (2022) Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicological Sciences 187:1, pages 25-34.
Crossref
Joel H Vazquez, Melissa M Clemens, Felicia D Allard, Eric U Yee, Stefanie Kennon-McGill, Samuel G Mackintosh, Hartmut Jaeschke, Michael D Hambuchen & Mitchell R McGill. (2020) Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations. Toxicological Sciences 173:2, pages 244-254.
Crossref
Steven C. Curry, Angela Padilla-Jones, Anne-Michelle Ruha, Ayrn D. O’Connor, A Min Kang, Diana G. Wilkins, Hartmut Jaeschke, Kelly Wilhelms & Richard D. Gerkin. (2019) The Relationship Between Circulating Acetaminophen-Protein Adduct Concentrations and Alanine Aminotransferase Activities in Patients With and Without Acetaminophen Overdose and Toxicity. Journal of Medical Toxicology 15:3, pages 143-155.
Crossref
H. Jaeschke, M.L. Bajt & A. Ramachandran. 2018. Comprehensive Toxicology. Comprehensive Toxicology 460 482 .
Mitchell R. McGill, Benjamin L. Woolbright, James L. Weemhoff & Hartmut Jaeschke. 2017. Biomarkers in Liver Disease. Biomarkers in Liver Disease 71 97 .
Shizhen Qin, Yong Zhou, Li Gray, Ulrike Kusebauch, Laurence McEvoy, Daniel J. Antoine, Lucy Hampson, Kevin B. Park, David Campbell, Juan Caballero, Gustavo Glusman, Xiaowei Yan, Taek-Kyun Kim, Yue Yuan, Kai Wang, Lee Rowen, Robert L. Moritz, Gilbert S. Omenn, Munir Pirmohamed & Leroy Hood. (2016) Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients. Journal of Proteome Research 15:10, pages 3724-3740.
Crossref
Ian Maina, Jody A Rule, Frank H WiansJr.Jr., Michael Poirier, Lafaine Grant & William M Lee. (2016) α-Glutathione S -Transferase: A New Biomarker for Liver Injury? . The Journal of Applied Laboratory Medicine 1:2, pages 119-128.
Crossref
Katarzyna Siemionow, Joanna Teul, Paweł Drągowski, Jerzy Pałka & Wojciech Miltyk. (2016) New potential biomarkers of acetaminophen-induced hepatotoxicity. Advances in Medical Sciences 61:2, pages 325-330.
Crossref
Mitchell R. McGill, Benjamin L. Woolbright, James L. Weemhoff & Hartmut Jaeschke. 2016. Biomarkers in Liver Disease. Biomarkers in Liver Disease 1 27 .
Richard D. Beger, Sudeepa Bhattacharyya, Xi Yang, Pritmohinder S. Gill, Laura K. Schnackenberg, Jinchun Sun & Laura P. James. (2015) Translational biomarkers of acetaminophen-induced acute liver injury. Archives of Toxicology 89:9, pages 1497-1522.
Crossref
Gyongyi Szabo & Jan Petrasek. (2015) Inflammasome activation and function in liver disease. Nature Reviews Gastroenterology & Hepatology 12:7, pages 387-400.
Crossref
Xi Yang, William F. Salminen, Qiang Shi, James Greenhaw, Pritmohinder S. Gill, Sudeepa Bhattacharyya, Richard D. Beger, Donna L. Mendrick, William B. Mattes & Laura P. James. (2015) Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children. Toxicology and Applied Pharmacology 284:2, pages 180-187.
Crossref
Hartmut Jaeschke. (2015) Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients. Digestive Diseases 33:4, pages 464-471.
Crossref
Mitchell R. McGill & Hartmut Jaeschke. 2015. Single Cell Sequencing and Systems Immunology. Single Cell Sequencing and Systems Immunology 143 154 .
Benjamin L. Woolbright, Mitchell R. McGill, Vincent S. Staggs, Robert D. Winefield, Parviz Gholami, Mojtaba Olyaee, Matthew R. Sharpe, Steven C. Curry, William M. Lee & Hartmut Jaeschke. (2014) Glycodeoxycholic Acid Levels as Prognostic Biomarker in Acetaminophen-Induced Acute Liver Failure Patients. Toxicological Sciences 142:2, pages 436-444.
Crossref
Yuchao Xie, Mitchell R. McGill, Kenneth Dorko, Sean C. Kumer, Timothy M. Schmitt, Jameson Forster & Hartmut Jaeschke. (2014) Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicology and Applied Pharmacology 279:3, pages 266-274.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.