204
Views
38
CrossRef citations to date
0
Altmetric
Research Article

Aberrant overexpression of EZH2 and H3K27me3 serves as poor prognostic biomarker for esophageal squamous cell carcinoma patients

, , , , &
Pages 80-90 | Received 31 Mar 2015, Accepted 01 Nov 2015, Published online: 03 Dec 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

He Huang, Peilin Zhong, Jianxing Zhang, Xinghe Chen, Jinwen Chen, Tian Lin & Qiang Wu. (2022) Human umbilical cord-mesenchymal stem cells-derived exosomes carrying microRNA-15a-5p possess therapeutic effects on Wilms tumor via regulating septin 2. Bioengineered 13:3, pages 6136-6148.
Read now

Articles from other publishers (36)

Mehrdad Hashemi, Naghmeh Nazdari, Ghazaleh Gholamiyan, Mahshid Deldar Abad Paskeh, Ali Moghadas Jafari, Fateme nemati, Elaheh Khodaei, Ghazal Abyari, Nazanin behdadfar, Behnaz raei, Rasoul Raesi, Noushin Nabavi, Peng Hu, Mohsen Rashidi, Afshin Taheriazam & Maliheh Entezari. (2023) EZH2 as a potential therapeutic target for gastrointestinal cancers. Pathology - Research and Practice, pages 154988.
Crossref
Nan Ding, Abin You, Senxia Zhao, Hu Yang, Chunping Lai & Feng Ye. (2023) EZH2 inhibitor Tazemetostat synergizes with JQ-1 in esophageal cancer by inhibiting c-Myc signaling pathway. Medical Oncology 40:10.
Crossref
Yimeng Zhang, Yuexin Zhang, Chao Song, Xilong Zhao, Bo Ai, Yuezhu Wang, Liwei Zhou, Jiang Zhu, Chenchen Feng, Liyan Xu, Qiuyu Wang, Hong Sun, Qiaoli Fang, Xiaozheng Xu, Enmin Li & Chunquan Li. (2023) CRdb: a comprehensive resource for deciphering chromatin regulators in human. Nucleic Acids Research 51:D1, pages D88-D100.
Crossref
Jemma Arakelyan, Daniil A. Rusanov, Meng Rui Chang, Aleksandra V. Asaturova, Galina S. Kireeva, Mana Alshehri, Wee Han Ang & Maria V. Babak. (2023) Targeting emerging cancer hallmarks by transition metal complexes: Epigenetic reprogramming and epitherapies. Part II. Coordination Chemistry Reviews 475, pages 214899.
Crossref
Jianzhang Qin, Yishuai Li, Zhe Li, Xuebo Qin, Xuetao Zhou, Hao Zhang & Shujun Li. (2022) LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1. Clinical Epigenetics 14:1.
Crossref
Amir Abbas Hamidi, Ghazaleh Khalili-Tanha, Zahra Nasrpour Navaei & Meysam Moghbeli. (2022) Long non-coding RNAs as the critical regulators of epithelial mesenchymal transition in colorectal tumor cells: an overview. Cancer Cell International 22:1.
Crossref
Charles Day, Edward Hinchcliffe & James Robinson. (2022) H3K27me3 in Diffuse Midline Glioma and Epithelial Ovarian Cancer: Opposing Epigenetic Changes Leading to the Same Poor Outcomes. Cells 11:21, pages 3376.
Crossref
Chen Hou, Lirong Xiao, Xiang Ren, Lin Cheng, Bo Guo, Meixia Zhang & Naihong Yan. (2022) EZH2-mediated H3K27me3 is a predictive biomarker and therapeutic target in uveal melanoma. Frontiers in Genetics 13.
Crossref
Shicong Zhu, Mei Liu, Fenglin Zhu, Xi Yu, Junsong Wen & Chengyin Li. (2022) Targeting EZH2 prevents the occurrence and mitigates the development of Sjögren's syndrome in mice. International Immunopharmacology 110, pages 109073.
Crossref
Cui Wu, Wu Song, Zhongnan Wang & Bingmei Wang. (2022) Functions of lncRNA DUXAP8 in non-small cell lung cancer. Molecular Biology Reports 49:3, pages 2531-2542.
Crossref
Jing Wang, Shanshan Cong, Han Wu, Yanan He, Xiaoli Liu, Liyuan Sun, Xibo Zhao & Guangmei Zhang. (2021) Identification and Analysis of Potential Autophagy-Related Biomarkers in Endometriosis by WGCNA. Frontiers in Molecular Biosciences 8.
Crossref
Eun Kyung Ko & Brian C. Capell. (2021) Methyltransferases in the Pathogenesis of Keratinocyte Cancers. Cancers 13:14, pages 3402.
Crossref
Sheila Coelho Soares-Lima, Hisham Mehanna, Diego Camuzi, Paulo Thiago de Souza-Santos, Tatiana de Almeida Simão, Pedro Nicolau-Neto, Monique de Souza Almeida Lopes, Cyrille Cuenin, Fazlur Rahman Talukdar, Nikolaos Batis, Izabella Costa, Fernando Dias, Davide Degli Esposti, Mariana Boroni, Zdenko Herceg & Luis Felipe Ribeiro Pinto. (2021) Upper Aerodigestive Tract Squamous Cell Carcinomas Show Distinct Overall DNA Methylation Profiles and Different Molecular Mechanisms behind WNT Signaling Disruption. Cancers 13:12, pages 3014.
Crossref
Phetmany Sihavong, Nakarin Kitkumthorn, Natchalee Srimaneekarn, Dusit Bumalee & Puangwan Lapthanasupkul. (2020) Differential Expression of EZH2 and H3K27me3 in Oral Verrucous Carcinoma and Oral Verrucous Hyperplasia. Head and Neck Pathology 15:2, pages 408-415.
Crossref
Theodore Vougiouklakis, Benjamin J. Bernard, Nupur Nigam, Kyunghee Burkitt, Yusuke Nakamura & Vassiliki Saloura. (2020) Clinicopathologic significance of protein lysine methyltransferases in cancer. Clinical Epigenetics 12:1.
Crossref
Asad Ur Rehman, Mohammad Askandar Iqbal, Real Sumayya Abdul Sattar, Snigdha Saikia, Mohammad Kashif, Wasif Mohammad Ali, Subhash Medhi, Sundeep Singh Saluja & Syed Akhtar Husain. (2020) Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from India. Cancer Cell International 20:1.
Crossref
Feng Li, Jing Zhang, Chao Ma, Ziqian Wang, Yinhua Li, Jimin Zhao & Kangdong Liu. (2020) Targeting Epigenetic Aberrations in Esophageal Squamous Cell Carcinoma. Current Pharmacology Reports 6:6, pages 415-428.
Crossref
Wenfang Cheng, Xiuling Shi, Mingqiang Lin, Qiwei Yao, Jiayu Ma & Jiancheng Li. (2020) LncRNA MAGI2-AS3 Overexpression Sensitizes Esophageal Cancer Cells to Irradiation Through Down-Regulation of HOXB7 via EZH2. Frontiers in Cell and Developmental Biology 8.
Crossref
Long Liao, Zi‐Ting Yao, Wang‐Kai Fang, Qing‐Yu He, Wen Wen Xu & Bin Li. (2020) Epigenetics in Esophageal Cancer: From Mechanisms to Therapeutics. Small Methods 4:10.
Crossref
Menghan Zhou, Yuhang Mao, Shenling Yu, Yiping Li, Rong Yin, Qin Zhang, Tianyu Lu, Rui Sun, Shaofeng Lin, Yanyan Qian, Ying Xu & Hong Fan. (2020) LINC00673 Represses CDKN2C and Promotes the Proliferation of Esophageal Squamous Cell Carcinoma Cells by EZH2-Mediated H3K27 Trimethylation. Frontiers in Oncology 10.
Crossref
Nair Lopes, Margareta P. Correia, Rui Henrique & Carmen Jerónimo. (2020) Epigenetic Alterations in Oesophageal Cancer: Expression and Role of the Involved Enzymes. International Journal of Molecular Sciences 21:10, pages 3522.
Crossref
Zhao-Yang Yang, Fang Yang, Ying-Li Zhang, Bao Liu, Meng Wang, Xuan Hong, Yan Yu, Yao-Hui Zhou & Hai Zeng. (2020) LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression. Cancer Biomarkers 18:1, pages 95-104.
Crossref
Bai-Quan Qiu, Xia-Hui Lin, Xu-Dong Ye, Wei Huang, Xu Pei, Dian Xiong, Xiang Long, Shu-Qiang Zhu, Feng Lu, Kun Lin, Xiao-Qiang Zhang, Jian-Jun Xu, Lu-Lu Sheng, Xue-Mei Zhang, Peng-Fei Zhang & Yong-Bing Wu. (2020) Long non-coding RNA PSMA3-AS1 promotes malignant phenotypes of esophageal cancer by modulating the miR-101/EZH2 axis as a ceRNA. Aging 12:2, pages 1843-1856.
Crossref
Pallabi Patowary, Dhruba K. Bhattacharyya & Pankaj Barah. (2020) Identifying critical genes in esophageal squamous cell carcinoma using an ensemble approach. Informatics in Medicine Unlocked 18, pages 100277.
Crossref
Ziqiang Tian, Zhenhua Li, Yonggang Zhu, Lingjiao Meng, Fei Liu, Meixiang Sang & Guiying Wang. (2019) Hypermethylation-mediated inactivation of miR-124 predicts poor prognosis and promotes tumor growth at least partially through targeting EZH2/H3K27me3 in ESCC. Clinical & Experimental Metastasis 36:4, pages 381-391.
Crossref
GholamReza Karami Madani, Abolfazl Rad, Mehdi Molavi, Sima Ardalan Khales, Mohammad Reza Abbaszadegan & Mohammad Mahdi Forghanifard. (2017) Predicting the Correlation of EZH2 and Cancer Stem Cell Markers in Esophageal Squamous Cell Carcinoma. Journal of Gastrointestinal Cancer 49:4, pages 437-441.
Crossref
Robert Charles Walker & Timothy James Underwood. (2018) Molecular pathways in the development and treatment of oesophageal cancer. Best Practice & Research Clinical Gastroenterology 36-37, pages 9-15.
Crossref
Fei Liu, Meixiang Sang, Lingjiao Meng, Lina Gu, Shina Liu, Juan Li & Cuizhi Geng. (2018) miR‑92b promotes autophagy and suppresses viability and invasion in breast cancer by targeting EZH2. International Journal of Oncology.
Crossref
Yuxin Tong, Yan Li, Hui Gu, Chunyu Wang, Funan Liu, Yangguang Shao & Feng Li. (2018) HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:4, pages 1104-1114.
Crossref
De-Chen Lin, Ming-Rong Wang & H. Phillip Koeffler. (2018) Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology 154:2, pages 374-389.
Crossref
Tongle Zhi, Tianfu Yu, Minhong Pan, Er Nie, Weining Wu, Xiefeng Wang, Ning Liu, Yongping You, Yingyi Wang & Junxia Zhang. (2017) EZH2 alteration driven by microRNA-524-5p and microRNA-324-5p promotes cell proliferation and temozolomide resistance in glioma. Oncotarget 8:56, pages 96239-96248.
Crossref
Elisa Paolicchi, Lorenzo Fornaro, Stefano Landi, Sushilaben Rigas & Francesco Crea. (2017) EZH2 Single Nucleotide Variants (SNVs): Diagnostic and Prognostic Role in 10 Solid Tumor Types. Epigenomes 1:3, pages 18.
Crossref
Yuting Gu, Jing Zhang & Huai Guan. (2017) Expression of EZH2 in endometrial carcinoma and its effects on proliferation and invasion of endometrial carcinoma cells. Oncology Letters.
Crossref
Jianbo Li, Zhifan Zheng & Min Fang. (2017) Impact of pretreatment plasma D-dimer levels and its perioperative change on prognosis in operable esophageal squamous cell carcinoma. Oncotarget 8:45, pages 79537-79545.
Crossref
Ying Cheng, Ying Li, Xin Huang, Wenbin Wei & Yi Qu. (2017) Expression of EZH2 in uveal melanomas patients and associations with prognosis. Oncotarget 8:44, pages 76423-76431.
Crossref
Anthos Christofides, Theodoros Karantanos, Kankana Bardhan & Vassiliki A. Boussiotis. (2016) Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2. Oncotarget 7:51, pages 85624-85640.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.