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Original Article

C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age

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Pages 244-252 | Received 24 Jan 1995, Accepted 02 May 1995, Published online: 10 Jul 2009

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Steven O. A. Oluwole, Yuanrong Yao, Sebastian Conradi, Krister Kristensson & Håkan Karlsson. (2007) Elevated levels of transcripts encoding a human retroviral envelope protein (syncytin) in muscles from patients with motor neuron disease. Amyotrophic Lateral Sclerosis 8:2, pages 67-72.
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Philippe Monteyne, Pierre G Coulie & Jean-Paul Coutelier. (2000) Analysis of the Fvl alleles involved in the susceptibility of mice to lactate dehydrogenase-elevating virus-induced polioencephalomyelitis. Journal of Neurovirology 6:1, pages 89-93.
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Zongyu Chen, Kehan Li, Raymond RR Rowland & Peter GW Plagemann. (1999) Selective antibody neutralization prevents neuropathogenic lactate dehydrogenase-elevating virus from causing paralytic disease in immunocompetent mice. Journal of Neurovirology 5:2, pages 200-208.
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Zongyu Chen, Kehan Li, Raymond RR Rowland, Grant W Anderson & Peter GW Plagemann. (1998) Lactate Dehydrogenase-Elevating Virus Variants: Cosegregation of Neuropathogenicity and Impaired Capability for High Viremic Persistent Infection. Journal of Neurovirology 4:5, pages 560-568.
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Philippe Monteyne, Mory Meite & Jean-Paul Coutelier. (1997) Involvement of CD4+ cells in the protection of C58 mouse against polioencephalomyelitis induced by lactate dehydrogenase-elevating virus. Journal of Neurovirology 3:5, pages 380-384.
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