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Research Article

Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: Results from an aborted randomised trial

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Pages 128-134 | Received 25 Feb 2010, Accepted 21 Oct 2010, Published online: 30 Nov 2010

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Naren P Rao & Gary Remington. (2013) Investigational drugs for schizophrenia targeting the dopamine receptor: Phase II trials. Expert Opinion on Investigational Drugs 22:7, pages 881-894.
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Taro Kishi, Toshikazu Ikuta, Yuki Matsui, Ken Inada, Yuki Matsuda, Kazuo Mishima & Nakao Iwata. (2018) Effect of discontinuation v. maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episode psychosis: a meta-analysis . Psychological Medicine 49:5, pages 772-779.
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Mark Taylor & Sameer Jauhar. (2019) Are we getting any better at staying better? The long view on relapse and recovery in first episode nonaffective psychosis and schizophrenia. Therapeutic Advances in Psychopharmacology 9, pages 204512531987003.
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Lex Wunderink. (2019) Personalizing antipsychotic treatment: evidence and thoughts on individualized tailoring of antipsychotic dosage in the treatment of psychotic disorders. Therapeutic Advances in Psychopharmacology 9, pages 204512531983656.
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Andrew Thompson, Catherine Winsper, Steven Marwaha, Jon Haynes, Mario Alvarez-Jimenez, Sarah Hetrick, Alba Realpe, Laura Vail, Sarah Dawson & Sarah A. Sullivan. (2018) Maintenance antipsychotic treatment versus discontinuation strategies following remission from first episode psychosis: systematic review. BJPsych Open 4:4, pages 215-225.
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Robin Emsley. (2018) Discontinuing antipsychotic treatment after a first-episode of psychosis: Who, when and how?. Schizophrenia Research 197, pages 59-60.
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D. R. Gotfredsen, R. S. Wils, C. Hjorthøj, S. F. Austin, N. Albert, R. G. Secher, A. A. E. Thorup, O. Mors & M. Nordentoft. (2017) Stability and development of psychotic symptoms and the use of antipsychotic medication – long-term follow-up. Psychological Medicine 47:12, pages 2118-2129.
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M. Alvarez-Jimenez, B. O’Donoghue, A. Thompson, J. F. Gleeson, S. Bendall, C. Gonzalez-Blanch, E. Killackey, L. Wunderink & P. D. McGorry. (2016) Beyond Clinical Remission in First Episode Psychosis: Thoughts on Antipsychotic Maintenance vs. Guided Discontinuation in the Functional Recovery Era. CNS Drugs 30:5, pages 357-368.
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Mei Hung Chi, Chih Yin Hsiao, Kao Chin Chen, Lan-Ting Lee, Hsin Chun Tsai, I Hui Lee, Po See Chen & Yen Kuang Yang. (2016) The readmission rate and medical cost of patients with schizophrenia after first hospitalization — A 10-year follow-up population-based study. Schizophrenia Research 170:1, pages 184-190.
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Wolfgang Gaebel, Mathias Riesbeck, Wolfgang Wölwer, Ansgar Klimke, Matthias Eickhoff, Martina von Wilmsdorff, Walter de Millas, Wolfgang Maier, Stephan Ruhrmann, Peter Falkai, Heinrich Sauer, Andrea Schmitt, Michael Riedel, Stefan Klingberg & Hans-Jürgen Möller. (2016) Predictors for symptom re-exacerbation after targeted stepwise drug discontinuation in first-episode schizophrenia. Schizophrenia Research 170:1, pages 168-176.
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Marc De Hert, Jan Sermon, Paul Geerts, Kristof Vansteelandt, Joseph Peuskens & Johan Detraux. (2015) The Use of Continuous Treatment Versus Placebo or Intermittent Treatment Strategies in Stabilized Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with First- and Second-Generation Antipsychotics. CNS Drugs 29:8, pages 637-658.
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Hannah Steeds, Robin L. Carhart-Harris & James M. Stone. (2014) Drug models of schizophrenia. Therapeutic Advances in Psychopharmacology 5:1, pages 43-58.
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Sofia Brissos, Miguel Ruiz Veguilla, David Taylor & Vicent Balanzá-Martinez. (2014) The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Therapeutic Advances in Psychopharmacology 4:5, pages 198-219.
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Robin Emsley, Bonginkosi Chiliza, Laila Asmal, Stefan du Plessis, Lebogang Phahladira, Evette van Niekerk, Susan J. van Rensburg & Brian H. Harvey. (2014) A randomized, controlled trial of omega-3 fatty acids plus an antioxidant for relapse prevention after antipsychotic discontinuation in first-episode schizophrenia. Schizophrenia Research 158:1-3, pages 230-235.
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Robert B. Zipursky, Natasja M. Menezes & David L. Streiner. (2014) Risk of symptom recurrence with medication discontinuation in first-episode psychosis: A systematic review. Schizophrenia Research 152:2-3, pages 408-414.
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Robin Emsley, Bonginkosi Chiliza, Laila Asmal & Brian H Harvey. (2013) The nature of relapse in schizophrenia. BMC Psychiatry 13:1.
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Robert B. Zipursky, Thomas J. Reilly & Robin M. Murray. (2013) The Myth of Schizophrenia as a Progressive Brain Disease. Schizophrenia Bulletin 39:6, pages 1363-1372.
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Stefan Leucht, Magdolna Tardy, Katja Komossa, Stephan Heres, Werner Kissling, Georgia Salanti & John M Davis. (2012) Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. The Lancet 379:9831, pages 2063-2071.
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Stefan Leucht, Magdolna Tardy, Katja Komossa, Stephan Heres, Werner Kissling & John M Davis. (2012) Maintenance treatment with antipsychotic drugs for schizophrenia. Cochrane Database of Systematic Reviews.
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