Advanced search
Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 117, 2011 - Issue 2
Submit an article Journal homepage
793
Views
56
CrossRef citations to date
0
Altmetric
Review Article

Promiscuous affairs of PKB/AKT isoforms in metabolism

Simon M. Schultze
,
Jørgen Jensen
,
Brian A. HemmingsFriedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
,
Oliver TschoppEndocrinology, Diabetology & Clinical Nutrition, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, Switzerland
&
Markus NiessenEndocrinology, Diabetology & Clinical Nutrition, University Hospital of Zurich, Raemistrasse 100, 8091 Zurich, SwitzerlandCorrespondence[email protected]
Pages 70-77 | Received 31 Oct 2010, Accepted 06 Nov 2010, Published online: 10 Jan 2011

Citations (56)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Omar Ramos-Lopez, Jose I. Riezu-Boj, Fermin I. Milagro & J. Alfredo Martinez. (2019) Association of Methylation Signatures at Hepatocellular Carcinoma Pathway Genes with Adiposity and Insulin Resistance Phenotypes. Nutrition and Cancer 71:5, pages 840-851.
Read now
Claudia Eberle, Markus Niessen, Brian A. Hemmings, Oliver Tschopp & Christoph Ament. (2014) Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα−−) in vivo model. Archives of Physiology and Biochemistry 120:3, pages 91-98.
Read now

Articles from other publishers (54)

Sandip Mukherjee, Molee Chakraborty, Eliwaza N. Msengi, Jake Haubner, Jinsong Zhang, Matthew J. Jellinek, Haley L. Carlson, Kelly Pyles, Barbara Ulmasov, Andrew J. Lutkewitte, Danielle Carpenter, Kyle S. McCommis, David A. Ford, Brian N. Finck, Brent A. Neuschwander-Tetri & Anutosh Chakraborty. (2023) Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo. Molecular Metabolism 75, pages 101767.
Crossref
Gagandeep Mann, Michael C. Riddell & Olasunkanmi A. J. Adegoke. (2022) Effects of Acute Muscle Contraction on the Key Molecules in Insulin and Akt Signaling in Skeletal Muscle in Health and in Insulin Resistant States. Diabetology 3:3, pages 423-446.
Crossref
P. Tulay, T. Onal & S. Vatansever. (2021) Molecular regulation of polycystic ovary syndrome: altered gene expression levels in mouse models pretreatment and post-treatment. Zygote 30:3, pages 352-357.
Crossref
Medha Sharma & Chinmoy Sankar Dey. (2021) AKT ISOFORMS-AS160-GLUT4: The defining axis of insulin resistance. Reviews in Endocrine and Metabolic Disorders 22:4, pages 973-986.
Crossref
Colleen L O'Reilly, Selina Uranga & James D Fluckey. (2021) Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes. World Journal of Biological Chemistry 12:5, pages 70-86.
Crossref
Crina E. Tiron, Emilia Patrașcanu, Paula A. Postu, Irina C. Vacarean Trandafir, Adrian Tiron & Ioana Grigoras. (2021) Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study. Current Issues in Molecular Biology 43:1, pages 264-275.
Crossref
Sandip Mukherjee, Jake Haubner & Anutosh Chakraborty. (2020) Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases. Molecules 25:6, pages 1403.
Crossref
Mark W. Pataky, Edward B. Arias, Haiyan Wang, Xiaohua Zheng & Gregory D. Cartee. (2020) Exercise effects on γ3-AMPK activity, phosphorylation of Akt2 and AS160, and insulin-stimulated glucose uptake in insulin-resistant rat skeletal muscle. Journal of Applied Physiology 128:2, pages 410-421.
Crossref
Bhoomika M. Patel & Ramesh K. Goyal. (2019) Liver and insulin resistance: New wine in old bottle!!!. European Journal of Pharmacology 862, pages 172657.
Crossref
Michael G. Sugiyama, Gregory D. Fairn & Costin N. Antonescu. (2019) Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling. Frontiers in Cell and Developmental Biology 7.
Crossref
Jessika Geisebel Oliveira Neto, Thais Bento-Bernardes, Carmen Cabanelas Pazos-Moura & Karen Jesus Oliveira. (2018) Maternal cinnamon intake during lactation led to visceral obesity and hepatic metabolic dysfunction in the adult male offspring. Endocrine 63:3, pages 520-530.
Crossref
Qiuxia Pan, Jiajia Wu, Yueyun Liu, Xiaojuan Li & Jiaxu Chen. (2019) Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats. Molecules 24:3, pages 480.
Crossref
Adriana Roura-Guiberna, Judith Hernandez-Aranda, Carlos Jorge Ramirez-Flores, Ricardo Mondragon-Flores, Nayely Garibay-Nieto, Gloria Queipo-Garcia, Estibalitz Laresgoiti-Servitje, Jae-Won Soh & Jesus Alberto Olivares-Reyes. (2019) Isomers of conjugated linoleic acid induce insulin resistance through a mechanism involving activation of protein kinase Cε in liver cells. Cellular Signalling 53, pages 281-293.
Crossref
Falguni Das, Nandini Ghosh-Choudhury, Doug Yoon Lee, Yves Gorin, Balakuntalam S. Kasinath & Goutam Ghosh Choudhury. (2018) Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression. PLOS ONE 13:11, pages e0207285.
Crossref
Linmu Chen, Jun Zhang, Xiao Deng, Yan Liu, Xi Yang, Qiong Wu & Chao Yu. (2017) Lysophosphatidic acid directly induces macrophage-derived foam cell formation by blocking the expression of SRBI. Biochemical and Biophysical Research Communications 491:3, pages 587-594.
Crossref
Sarah M Leiter, Victoria E R Parker, Alena Welters, Rachel Knox, Nuno Rocha, Graeme Clark, Felicity Payne, Luca Lotta, Julie Harris, Julio Guerrero-Fernández, Isabel González-Casado, Sixto García-Miñaur, Gema Gordo, Nick Wareham, Víctor Martínez-Glez, Michael Allison, Stephen O’Rahilly, Inês Barroso, Thomas Meissner, Susan Davies, Khalid Hussain, Karen Temple, Ana-Coral Barreda-Bonis, Sebastian Kummer & Robert K Semple. (2017) Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase. European Journal of Endocrinology 177:2, pages 175-186.
Crossref
S. da Silva Teixeira, C. Filgueira, D. H. Sieglaff, C. Benod, R. Villagomez, L. J. Minze, A. Zhang, P. Webb & M. T. Nunes. (2017) 3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice. Acta Physiologica 220:2, pages 238-250.
Crossref
Nara Shin, Min-Hee Yi, Sena Kim, Hyunjung Baek, Ursula L. Triantafillu, Jongsun Park & Dong Woon Kim. (2017) Astrocytic Expression of CTMP Following an Excitotoxic Lesion in the Mouse Hippocampus. Experimental Neurobiology 26:1, pages 25-32.
Crossref
Xiaohua Zheng & Gregory D. Cartee. (2016) Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle. Scientific Reports 6:1.
Crossref
Anne M. Cieniewicz, Philip R. Cooper, Jennifer McGehee, Russell B. Lingham & Anthony J. Kihm. (2016) Novel method demonstrates differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation. Cellular Signalling 28:8, pages 1037-1047.
Crossref
Erin E. Talbert & Denis C. Guttridge. (2016) Impaired regeneration: A role for the muscle microenvironment in cancer cachexia. Seminars in Cell & Developmental Biology 54, pages 82-91.
Crossref
Dai Li, Hui Chen, Xiao-Huan Luo, Yang Sun, Wei Xia & Yuan-Chang Xiong. (2016) CX3CR1-Mediated Akt1 Activation Contributes to the Paclitaxel-Induced Painful Peripheral Neuropathy in Rats. Neurochemical Research 41:6, pages 1305-1314.
Crossref
Atul S. Deshmukh. (2016) Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. Hormone Molecular Biology and Clinical Investigation 26:1, pages 13-24.
Crossref
Matthew J. Eramo & Christina A. Mitchell. (2016) Regulation of PtdIns(3,4,5) P 3/Akt signalling by inositol polyphosphate 5-phosphatases . Biochemical Society Transactions 44:1, pages 240-252.
Crossref
Anjum Riaz, Ying Huang & Staffan Johansson. (2016) G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. International Journal of Molecular Sciences 17:2, pages 215.
Crossref
Hamood AlSudais, Kawther Aabed, William Nicola, Katherine Dixon, Jihong Chen & Qiao Li. (2016) Retinoid X Receptor-selective Signaling in the Regulation of Akt/Protein Kinase B Isoform-specific Expression. Journal of Biological Chemistry 291:6, pages 3090-3099.
Crossref
Jo Suda, Don C. Rockey & Serhan Karvar. (2015) RETRACTED ARTICLE: Akt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells. Digestive Diseases and Sciences 61:2, pages 453-463.
Crossref
Sneha Surendran, Victoria N. Jideonwo, Chris Merchun, Miwon Ahn, John Murray, Jennifer Ryan, Kenneth W. Dunn, Janaiah Kota & Núria Morral. (2016) Gene targets of mouse miR-709: regulation of distinct pools. Scientific Reports 6:1.
Crossref
Eric Goetzman. 2015. Mitochondria in Liver Disease. Mitochondria in Liver Disease 451 472 .
Maren G. Dietrich, Richard A. Zuellig, Giatgen A. Spinas, Roger Lehmann, Oliver Tschopp & Markus Niessen. (2015) Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets. Experimental Cell Research 338:1, pages 82-88.
Crossref
Swati S. Jain, Joost J.F.P. Luiken, Laelie A. Snook, Xiao Xia Han, Graham P. Holloway, Jan F.C. Glatz & Arend Bonen. (2015) Fatty acid transport and transporters in muscle are critically regulated by Akt2. FEBS Letters 589:19PartB, pages 2769-2775.
Crossref
Jihong Chen, Yingjian Wang, Munerah Hamed, Natascha Lacroix & Qiao Li. (2015) Molecular Basis for the Regulation of Transcriptional Coactivator p300 in Myogenic Differentiation. Scientific Reports 5:1.
Crossref
Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Ying Wang & Tong Wu. (2015) miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT. PLOS ONE 10:7, pages e0132734.
Crossref
Emelie M. Gårdebjer, Stephen T. Anderson, Marie Pantaleon, Mary E. Wlodek & Karen M. Moritz. (2015) Maternal alcohol intake around the time of conception causes glucose intolerance and insulin insensitivity in rat offspring, which is exacerbated by a postnatal high‐fat diet. The FASEB Journal 29:7, pages 2690-2701.
Crossref
Guido Sebastiani, Agnese Po, Evelina Miele, Giuliana Ventriglia, Elena Ceccarelli, Marco Bugliani, Lorella Marselli, Piero Marchetti, Alberto Gulino, Elisabetta Ferretti & Francesco Dotta. (2014) MicroRNA-124a is hyperexpressed in type 2 diabetic human pancreatic islets and negatively regulates insulin secretion. Acta Diabetologica 52:3, pages 523-530.
Crossref
Shlomit Koren, Lisa M. DiPilato, Matthew J. Emmett, Abigail L. Shearin, Qingwei Chu, Bob Monks & Morris J. Birnbaum. (2015) The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo. Diabetologia 58:5, pages 1063-1070.
Crossref
Simon M. Schultze, Maren Dietrich, Debby Hynx, Andreas Geier, Markus Niessen, Giatgen A. Spinas, Brian A. Hemmings & Oliver Tschopp. (2015) Reduced hepatic lipid content in Pten -haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle . Liver International 35:4, pages 1354-1366.
Crossref
Q. Liu, K. M. Turner, W. K. Alfred Yung, K. Chen & W. Zhang. (2014) Role of AKT signaling in DNA repair and clinical response to cancer therapy. Neuro-Oncology 16:10, pages 1313-1323.
Crossref
Abbe R. ClarkAlex Toker. (2014) Signalling specificity in the Akt pathway in breast cancer. Biochemical Society Transactions 42:5, pages 1349-1355.
Crossref
W. J. Pang, N. Wei, Y. Wang, Y. Xiong, F. F. Chen, W. J. Wu, C. Z. Zhao, S. D. Sun & G. S. Yang. (2014) Obese and lean porcine difference of FoxO1 and its regulation through C/EBP  and PI3K/GSK3  signaling pathway. Journal of Animal Science 92:5, pages 1968-1979.
Crossref
Chris McGloryAmanda WhiteCaroline TreinsBarry Drust, Graeme L. Close, Don P. M. MacLaren, Iain T. Campbell, Andrew Philp, Simon SchenkJames P. Morton & D. Lee Hamilton. (2014) Application of the [γ- 32 P] ATP kinase assay to study anabolic signaling in human skeletal muscle . Journal of Applied Physiology 116:5, pages 504-513.
Crossref
Benjamin G. Challis & Robert K. Semple. (2013) Genetic Disorders of Insulin Action: Far More than Diabetes. Current Obesity Reports 2:4, pages 293-300.
Crossref
Jisoo Park, Kisang Kwon, Seon-Hwan Kim, Min-Hee Yi, Enji Zhang, Gyeyeong Kong, Dong Woon Kim & Jongsun Park. (2013) Astrocytic phosphorylation of PDK1 on Tyr9 following an excitotoxic lesion in the mouse hippocampus. Brain Research 1533, pages 37-43.
Crossref
Weijun Pang, Yu Wang, Ning Wei, Ruxiang Xu, Yan Xiong, Ping Wang, Qingwu Shen & Gongshe Yang. (2013) Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction. PLoS ONE 8:8, pages e71576.
Crossref
Jie Lin, Deepak Sampath, Michelle A. Nannini, Brian B. Lee, Michael Degtyarev, Jason Oeh, Heidi Savage, Zhengyu Guan, Rebecca Hong, Robert Kassees, Leslie B. Lee, Tyler Risom, Stefan Gross, Bianca M. Liederer, Hartmut Koeppen, Nicholas J. Skelton, Jeffrey J. Wallin, Marcia Belvin, Elizabeth Punnoose, Lori S. Friedman & Kui Lin. (2013) Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models. Clinical Cancer Research 19:7, pages 1760-1772.
Crossref
Christopher J. Barker & Per-Olof Berggren. (2013) New Horizons in Cellular Regulation by Inositol Polyphosphates: Insights from the Pancreatic β -Cell . Pharmacological Reviews 65:2, pages 641-669.
Crossref
Lake Q. Jiang, Daniella E. Duque-Guimaraes, Ubiratan F. Machado, Juleen R. Zierath & Anna Krook. (2013) Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients. Diabetes 62:2, pages 355-361.
Crossref
Waqar Ahmad. (2012) Overlapped Metabolic and Therapeutic Links between Alzheimer and Diabetes. Molecular Neurobiology 47:1, pages 399-424.
Crossref
Gaetano Romano. (2013) The Role of the Dysfunctional Akt-Related Pathway in Cancer: Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development. Scientifica 2013, pages 1-12.
Crossref
Pamela Fischer-Posovszky, Daniel Tews, Sina Horenburg, Klaus-Michael Debatin & Martin Wabitsch. (2012) Differential function of Akt1 and Akt2 in human adipocytes. Molecular and Cellular Endocrinology 358:1, pages 135-143.
Crossref
Dara Leto & Alan R. Saltiel. (2012) Regulation of glucose transport by insulin: traffic control of GLUT4. Nature Reviews Molecular Cell Biology 13:6, pages 383-396.
Crossref
Hector Diez, Juan Jose Garrido & Francisco Wandosell. (2012) Specific Roles of Akt iso Forms in Apoptosis and Axon Growth Regulation in Neurons. PLoS ONE 7:4, pages e32715.
Crossref
Simon M. Schultze, Brian A. Hemmings, Markus Niessen & Oliver Tschopp. (2012) PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. Expert Reviews in Molecular Medicine 14.
Crossref
Henrike Sell, Jørgen Jensen & Juergen Eckel. 2012. Animal Models in Diabetes Research. Animal Models in Diabetes Research 255 263 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.