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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 117, 2011 - Issue 3
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Research Article

G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance

Federico Mayor Jr.Correspondence[email protected]
,
Elisa Lucas
,
María Jurado-Pueyo
,
Lucia Garcia-GuerraInstituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Arturo Duperier, 4, 28029 Madrid
,
Iria Nieto-Vazquez
,
Rocio Vila-Bedmar
,
Sonia Fernández-Veledo
&
Cristina Murga
 show all
Pages 125-130 | Received 11 Apr 2011, Accepted 26 Apr 2011, Published online: 26 May 2011

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Elisa Lucas, Marta Cruces-Sande, Ana M. Briones, Mercedes Salaices, Federico Mayor$suffix/text()$suffix/text(), Cristina Murga & Rocio Vila-Bedmar. (2015) Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2. Archives of Physiology and Biochemistry 121:5, pages 163-177.
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Articles from other publishers (27)

Daniela Liccardo, Beatrice Arosio, Graziamaria Corbi & Alessandro Cannavo. (2022) Sex/Gender- and Age-Related Differences in β-Adrenergic Receptor Signaling in Cardiovascular Diseases. Journal of Clinical Medicine 11:15, pages 4280.
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Huijuan Cheng, Paipai Guo, Tiantian Su, Chunru Jiang, Zhenduo Zhu, Wei Wei, Lingling Zhang & Qingtong Wang. (2022) G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions and inflammation. Cellular Signalling 95, pages 110337.
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Rocío Vila-Bedmar, Marta Cruces-Sande, Alba C. Arcones, Hanneke L. D. M. Willemen, Patricia Prieto, Isabel Moreno-Indias, Daniel Díaz-Rodríguez, Sara Francisco, Rafael I. Jaén, Carolina Gutiérrez-Repiso, Cobi J. Heijnen, Lisardo Boscá, Manuel Fresno, Annemieke Kavelaars, Federico MayorJrJr & Cristina Murga. (2020) GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity. Cellular and Molecular Life Sciences 77:23, pages 4957-4976.
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María González-Amor, Rocío Vila-Bedmar, Raquel Rodrigues-Díez, Rosa Moreno-Carriles, Alba C. Arcones, Marta Cruces-Sande, Mercedes Salaices, Federico MayorJr.Jr., Ana M. Briones & Cristina Murga. (2020) Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue. Antioxidants 9:10, pages 953.
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Alessandro Cannavo, Federica Marzano, Andrea Elia, Daniela Liccardo, Leonardo Bencivenga, Giuseppina Gambino, Claudia Perna, Antonio Rapacciuolo, Antonio Cittadini, Nicola Ferrara, Nazareno Paolocci, Walter J. Koch & Giuseppe Rengo. (2019) Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling via G Protein-Coupled Receptor Kinase 2. Frontiers in Pharmacology 10.
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Ni Yang, Shihong Li, Shouqing Liu, Yifan Lv, Liangyu Yu, Yahui Deng, Huqun Li, Maosheng Fang, Yunxiang Huo, Weiyong Li & Shiyong Peng. (2019) Insulin Resistance–Related Proteins Are Overexpressed in Patients and Rats Treated With Olanzapine and Are Reverted by Pueraria in the Rat Model. Journal of Clinical Psychopharmacology 39:3, pages 214-219.
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Ersilia Cipolletta, Jessica Gambardella, Antonella Fiordelisi, Carmine Del Giudice, Eugenio Di Vaia, Michele Ciccarelli, Marina Sala, Pietro Campiglia, Enrico Coscioni, Bruno Trimarco, Daniela Sorriento & Guido Iaccarino. (2019) Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice. International Journal of Molecular Sciences 20:6, pages 1492.
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Cristina Murga, Alba C. Arcones, Marta Cruces-Sande, Ana M. Briones, Mercedes Salaices & Federico Mayor Jr.. (2019) G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases. Frontiers in Pharmacology 10.
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Laurel A. Grisanti, Sarah M. Schumacher, Douglas G. Tilley & Walter J. Koch. (2018) Designer Approaches for G Protein–Coupled Receptor Modulation for Cardiovascular Disease. JACC: Basic to Translational Science 3:4, pages 550-562.
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Sarah M. Schumacher & Walter J. Koch. (2017) Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling. Journal of Cardiovascular Pharmacology 70:3, pages 129-141.
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Kumiko Taguchi, Mari Hida, Mami Hasegawa, Haruka Narimatsu, Takayuki Matsumoto & Tsuneo Kobayashi. (2017) Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis. Scientific Reports 7:1.
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Valeria Rudomanova & Burns C. Blaxall. (2017) Targeting GPCR-Gβγ-GRK2 signaling as a novel strategy for treating cardiorenal pathologies. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:8, pages 1883-1892.
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Elisa Lucas, Rocio Vila-Bedmar, Alba C. Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico MayorJr.Jr. & Cristina Murga. (2016) Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels. Cardiovascular Diabetology 15:1.
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Zhengyu Zha, Xiao-Ran Han, Matthew D Smith, Qun-Ying Lei, Kun-Liang Guan & Yue Xiong. (2016) Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination. Cell Discovery 2:1.
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Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen & Annemieke Kavelaars. 2016. G Protein-Coupled Receptor Kinases. G Protein-Coupled Receptor Kinases 187 213 .
Rocio Vila-BedmarMarta Cruces-SandeElisa LucasHanneke L. D. M. WillemenCobi J. HeijnenAnnemieke KavelaarsFederico MayorJr.Jr. & Cristina Murga. (2015) Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2. Science Signaling 8:386.
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Caitrin Crudden, Marina Ilic, Naida Suleymanova, Claire Worrall, Ada Girnita & Leonard Girnita. (2015) The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment?. Growth Hormone & IGF Research 25:1, pages 2-12.
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L.S. Litvinova, E.V. Kirienkova, I.O. Mazunin, M.A. Vasilenko & N.S. Fattakhov. (2015) Insulin resistance pathogenesis in metabolic obesity. Biomeditsinskaya Khimiya 61:1, pages 70-82.
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Gaetano Santulli. 2015. The Cardiovascular Adrenergic System. The Cardiovascular Adrenergic System 97 116 .
L. S. Litvinova, E. V. Kirienkova, I. O. Mazunin, M. A. Vasilenko & N. S. Fattakhov. (2014) Pathogenesis of insulin resistance in metabolic obesity. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 8:3, pages 192-202.
Crossref
Meryl C. WoodallMichele CiccarelliBenjamin P. WoodallWalter J. Koch. (2014) G Protein–Coupled Receptor Kinase 2. Circulation Research 114:10, pages 1661-1670.
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Victòria Ceperuelo-Mallafré, Xavier Duran, Gisela Pachón, Kelly Roche, Lourdes Garrido-Sánchez, Nuria Vilarrasa, Francisco J. Tinahones, Vicente Vicente, Jordi Pujol, Joan Vendrell & Sonia Fernández-Veledo. (2014) Disruption of GIP/GIPR Axis in Human Adipose Tissue Is Linked to Obesity and Insulin Resistance. The Journal of Clinical Endocrinology & Metabolism 99:5, pages E908-E919.
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Feng Ling Wang, Li Qin Tang, Feng Yang, Ling Na Zhu, Ming Cai & Wei Wei. (2012) Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Molecular Biology Reports 40:3, pages 2405-2418.
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Rocio Vila‐Bedmar, Lucia Garcia‐Guerra, Iria Nieto‐Vazquez, Federico MayorJr.Jr., Margarita Lorenzo, Cristina Murga & Sonia Fernández‐Veledo. (2012) GRK2 contribution to the regulation of energy expenditure and brown fat function. The FASEB Journal 26:8, pages 3503-3514.
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Feng-Ling Wang, Li-Qin Tang & Wei Wei. (2012) The connection between GRKs and various signaling pathways involved in diabetic nephropathy. Molecular Biology Reports 39:7, pages 7717-7726.
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Sandro M. Hirabara, Renata Gorjão, Marco A. Vinolo, Alice C. Rodrigues, Renato T. Nachbar & Rui Curi. (2012) Molecular Targets Related to Inflammation and Insulin Resistance and Potential Interventions. Journal of Biomedicine and Biotechnology 2012, pages 1-16.
Crossref
Hitoshi Kurose. (2011) Atypical Actions of G Protein-Coupled Receptor Kinases. Biomolecules and Therapeutics 19:4, pages 390-397.
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