Advanced search
Publication Cover
Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 122, 2016 - Issue 2
Submit an article Journal homepage
506
Views
55
CrossRef citations to date
0
Altmetric
Original Article

Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model

Arij HarzallahBiochemistry Laboratory, Research Laboratory LR12ES05: Lab-NAFS ‘Nutrition – Functional Food & Vascular Health’, Faculty of Medicine, University of Monastir, Monastir, Tunisia and
,
Mohamed HammamiBiochemistry Laboratory, Research Laboratory LR12ES05: Lab-NAFS ‘Nutrition – Functional Food & Vascular Health’, Faculty of Medicine, University of Monastir, Monastir, Tunisia and
,
Malgorzata A. KępczyńskaBuckingham Institute for Translational Medicine, Clore Laboratory, University of Buckingham, Buckingham, UK
,
David C. HislopBuckingham Institute for Translational Medicine, Clore Laboratory, University of Buckingham, Buckingham, UK
,
Jonathan R. S. ArchBuckingham Institute for Translational Medicine, Clore Laboratory, University of Buckingham, Buckingham, UK
,
Michael A. CawthorneBuckingham Institute for Translational Medicine, Clore Laboratory, University of Buckingham, Buckingham, UK
&
Mohamed S. ZaibiBuckingham Institute for Translational Medicine, Clore Laboratory, University of Buckingham, Buckingham, UKCorrespondence[email protected]
 show all
Pages 75-87 | Received 23 Dec 2015, Accepted 25 Jan 2016, Published online: 26 Feb 2016

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Nicolas Jeria, Sebastian Cornejo, Gabriel Prado, Andres Bustamante, Diego F Garcia-Diaz, Paula Jimenez, Rodrigo Valenzuela, Carlos Poblete-Aro & Francisca Echeverria. (2023) Beneficial Effects of Bioactive Compounds Obtained from Agro-Industrial By-Products on Obesity and Metabolic Syndrome Components. Food Reviews International 39:7, pages 3753-3782.
Read now
Shahrokh Bagheri, Reza Mohammadrezaei Khorramabadi, Vahideh Assadollahi, Peyman Khosravi, Ahmad Cheraghi Venol, Saeed Veiskerami & Hassan Ahmadvand. (2023) The effects of pomegranate peel extract on the gene expressions of antioxidant enzymes in a rat model of alloxan-induced diabetes. Archives of Physiology and Biochemistry 129:4, pages 870-878.
Read now
Nilgün Yenil, Fadim Yemiş, İsrafil Sabikoglu, Najma Memon & Ali Güler. (2023) Comparative Analyses of Few West Turkish Varieties of Pomegranate (Punica granatum L.) Peels for Phenolic Content Using Liquid Chromatography. Polycyclic Aromatic Compounds 43:5, pages 3941-3957.
Read now
P. Ramlagan, P. Rondeau, V. S. Neergheen, E. Bourdon & T. Bahorun. (2021) The Prophylactic Activity of Punica granatum L. mesocarp Protects Preadipocytes against Ribosylated BSA-Induced Toxicity. Journal of the American College of Nutrition 40:6, pages 502-516.
Read now
Meryem Berrichi, Chahid Benammar, Babar Murtaza, Aziz Hichami, Meriem Belarbi & Naim Akhtar Khan. (2021) Zizyphus lotus L. fruit attenuates obesity-associated alterations: in vivo mechanisms. Archives of Physiology and Biochemistry 127:2, pages 119-126.
Read now

Articles from other publishers (50)

Ghanya Al-Naqeb, Aliki Kalmpourtzidou, Rachele De Giuseppe & Hellas Cena. (2023) Beneficial Effects of Plant Oils Supplementation on Multiple Sclerosis: A Comprehensive Review of Clinical and Experimental Studies. Nutrients 15:22, pages 4827.
Crossref
Joanna Niewiadomska, Ewa Kumiega, Michał Płóciennik, Jacek Gajek & Agnieszka Noszczyk-Nowak. (2023) Effects of Punica granatum L. peel extract supplementation on body weight, cardiac function, and haematological and biochemical parameters in an animal model of metabolic syndrome . Journal of Veterinary Research 67:2, pages 219-232.
Crossref
Angelene Lyn Xin Kwok, Himali Balasooriya & Ken Ng. (2023) Efficacy of ellagic acid and ellagitannins on diabetes mellitus: A meta-analysis of preclinical and clinical trials. Food Bioscience 53, pages 102573.
Crossref
Bhupinder Kumar, Shah Alam Khan & Md Jawaid Akhtar. 2023. Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods. Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods 171 209 .
Zahra Amri, Ikram Ben Amor, Amira Zarrouk, Raja Chaaba, Jalel Gargouri, Mohamed Hammami & Sonia Hammami. (2022) Anti-glycation, antiplatelet and antioxidant effects of different pomegranate parts. BMC Complementary Medicine and Therapies 22:1.
Crossref
Hassan Rakhshandeh, Vafa Baradaran Rahimi, Zahra Habibi, Zahra Sirousi & Vahid Reza Askari. (2022) Punica granatum seed oil detracts peritoneal adhesion: Perusing antioxidant, anti‐inflammatory, antifibrotic, and antiangiogenic impacts . Physiological Reports 10:24.
Crossref
Mohammad Javad Emami Kazemabad, Sara Asgari Toni, Neda Tizro, Parisa Alsadat Dadkhah, Hanieh Amani, Shima Akhavan Rezayat, Zahra Sheikh, Mohammad Mohammadi, Dorsa Alijanzadeh, Farnoosh Alimohammadi, Mehregan Shahrokhi, Gisou Erabi, Masoud Noroozi, Mohammad Amin Karimi, Sara Honari & Niloofar Deravi. (2022) Pharmacotherapeutic potential of pomegranate in age-related neurological disorders. Frontiers in Aging Neuroscience 14.
Crossref
R. Harischandra Naik, M.S. Pallavi, Nandini, A. Shwetha, M. Bheemanna & R. Udaykumar Nidoni. (2022) Simultaneous determination of pesticide residues in pomegranate whole fruit and arils using LC-MS/MS. Food Chemistry 387, pages 132865.
Crossref
Manuela Machado, Eduardo M. Costa, Sara Silva, Luís M. Rodriguez-Alcalá, Ana M. Gomes & Manuela Pintado. (2022) Pomegranate Oil’s Potential as an Anti-Obesity Ingredient. Molecules 27:15, pages 4958.
Crossref
Uroosa Noor, Shashi Soni & Ena Gupta. (2022) Punica granatum Peel Waste - An Underutilized Substrate of Therapeutic Potential: An Overview . Recent Advances in Food, Nutrition & Agriculture 13:2, pages 103-119.
Crossref
Haizhao Song, Xinchun Shen, Rou Deng, Qiang Chu & Xiaodong Zheng. (2022) Pomegranate peel anthocyanins prevent diet-induced obesity and insulin resistance in association with modulation of the gut microbiota in mice. European Journal of Nutrition 61:4, pages 1837-1847.
Crossref
A. Mnari Bhouri, H. Ghnimi, Z. Amri, N. Koubaa & M. Hammami. (2022) Effect of tunisian pomegranate peel extract on the oxidative stability of corn oil under heating conditions. Grasas y Aceites 73:1, pages e449.
Crossref
Haizhao Song, Xinchun Shen, Qiang Chu & Xiaodong Zheng. (2021) Pomegranate fruit pulp polyphenols reduce diet‐induced obesity with modulation of gut microbiota in mice. Journal of the Science of Food and Agriculture 102:5, pages 1968-1977.
Crossref
María de la Luz Cádiz-Gurrea, Álvaro Fernández-Ochoa, María del Carmen Villegas-Aguilar, David Arráez-Román & Antonio Segura-Carretero. (2022) Therapeutic Targets for Phenolic Compounds from Agro-industrial By-products against Obesity. Current Medicinal Chemistry 29:6, pages 1083-1098.
Crossref
Fawzyah Abdullah Mohammed Al-Ghamdi. (2022) Pomegranate peel extracts effects to reduce mono sodium glutamate toxic effects on chicken embryos: Morphological studies. Saudi Journal of Biological Sciences 29:2, pages 975-983.
Crossref
Gaofeng Yuan. 2022. Advances in Dietary Lipids and Human Health. Advances in Dietary Lipids and Human Health 251 271 .
Chinyere S. Dike, Chinna N. Orish, Chukwuemeka R. Nwokocha, Francis D. Sikoki, Bolaji B. Babatunde, Chiara Frazzoli & Orish E. Orisakwe. (2021) Phytowaste as nutraceuticals in boosting public health. Clinical Phytoscience 7:1.
Crossref
Gaurav Kumar, Sanjay Kumar Dey & Suman Kundu. (2021) Herbs and their bioactive ingredients in cardio-protection: Underlying molecular mechanisms and evidences from clinical studies. Phytomedicine 92, pages 153753.
Crossref
Francisca Echeverria, Paula Andrea Jimenez Patino, Mauricio Castro-Sepulveda, Andres Bustamante, Paula Andrea Garcia Concha, Carlos Poblete-Aro, Rodrigo Valenzuela & Diego F. Garcia-Diaz. (2020) Microencapsulated pomegranate peel extract induces mitochondrial complex IV activity and prevents mitochondrial cristae alteration in brown adipose tissue in mice fed on a high-fat diet. British Journal of Nutrition 126:6, pages 825-836.
Crossref
Khojasteh Malekmohammad, Evgeny E. Bezsonov & Mahmoud Rafieian-Kopaei. (2021) Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms. Frontiers in Cardiovascular Medicine 8.
Crossref
Gowtham Subramanian, Deepankumar Shanmugamprema, Ramya Subramani, Karthi Muthuswamy, Vinithra Ponnusamy, Kalpana Tankay, Thirunavukkarasu Velusamy, Vasanth Krishnan & Selvakumar Subramaniam. (2021) Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy . Molecular Nutrition & Food Research 65:10, pages 2001224.
Crossref
Caitlin R. Coker, Bailey N. Keller, Amy C. Arnold & Yuval Silberman. (2021) Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function. Frontiers in Behavioral Neuroscience 14.
Crossref
Monire Seyed Hashemi, Nasim Namiranian, Hemaseh Tavahen, Abolfazl Dehghanpour, Mohammad Hadi Rad, Saeedeh Jam-Ashkezari, Majid Emtiazy & Mohammad Hashem Hashempur. (2021) Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial. Complementary Medicine Research 28:3, pages 226-233.
Crossref
Antonio J. Amor, Carmen Gómez-Guerrero, Emilio Ortega, Aleix Sala-Vila & Iolanda Lázaro. (2020) Ellagic Acid as a Tool to Limit the Diabetes Burden: Updated Evidence. Antioxidants 9:12, pages 1226.
Crossref
Zahra Amri, Mohamed Raâfet Ben Khedher, Mohamed Sghaier Zaibi, Wafa Kharroubi, Mouna Turki, Fatma Ayadi & Mohamed Hammami. (2020) Anti-diabetic effects of pomegranate extracts in long-term high fructose-fat fed rats. Clinical Phytoscience 6:1.
Crossref
Jie Xu, Ke Cao, Lin Zhao, Zhihui Feng, Zhizhong Dong, Jianke Li & Jiankang Liu. (2021) The effects and mechanisms of pomegranate in the prevention and treatment of metabolic syndrome. Traditional Medicine and Modern Medicine 03:04, pages 223-237.
Crossref
Mariam Fourati, Slim Smaoui, Hajer Ben Hlima, Khaoula Elhadef, Olfa Ben Braïek, Karim Ennouri, Ahlem Chakchouk Mtibaa & Lotfi Mellouli. (2020) Bioactive Compounds and Pharmacological Potential of Pomegranate (Punica granatum) Seeds - A Review. Plant Foods for Human Nutrition 75:4, pages 477-486.
Crossref
Nathalie T.B. Delgado, Wender N. Rouver & Roger L. dos Santos. (2020) Protective Effects of Pomegranate in Endothelial Dysfunction. Current Pharmaceutical Design 26:30, pages 3684-3699.
Crossref
Valentina Parisi, Antonio Vassallo, Claudio Pisano, Giacomo Signorino, Francesco Cardile, Milena Sorrentino, Fabiana Colelli, Alessandra Fucci, Egildo Luca D’Andrea, Nunziatina Tommasi, Alessandra Braca & Marinella Leo. (2020) A Herbal Mixture from Propolis, Pomegranate, and Grape Pomace Endowed with Anti-Inflammatory Activity in an In Vivo Rheumatoid Arthritis Model. Molecules 25:9, pages 2255.
Crossref
Tatiana V. Kirichenko, Vasily N. Sukhorukov, Alexander M. Markin, Nikita G. Nikiforov, Ping-Yen Liu, Igor A. Sobenin, Vadim V. Tarasov, Alexander N. Orekhov & Gjumrakch Aliev. (2020) Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis. Frontiers in Pharmacology 11.
Crossref
Vafa Baradaran Rahimi, Mobarakeh Ghadiri, Mobina Ramezani & Vahid Reza Askari. (2020) Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies. Phytotherapy Research 34:4, pages 685-720.
Crossref
Marcelo Florencio Passos Silva, Patricia Lucio Alves, Rafaela Fadoni Alponti, Paulo Flavio Silveira & Fernando Maurício Francis Abdalla. (2019) Effects of obesity induced by high-calorie diet and its treatment with exenatide on muscarinic acetylcholine receptors in rat hippocampus. Biochemical Pharmacology 169, pages 113630.
Crossref
Yaser Khajebishak, Laleh Payahoo, Mohammadreza Alivand, Hamed Hamishehkar, Majid Mobasseri, Vahide Ebrahimzadeh, Mahdiye Alipour & Beitollah Alipour. (2019) Effect of pomegranate seed oil supplementation on the GLUT‐4 gene expression and glycemic control in obese people with type 2 diabetes: A randomized controlled clinical trial. Journal of Cellular Physiology 234:11, pages 19621-19628.
Crossref
Nadia M. El-Beih, Gamal Ramadan, Enas A. El-Husseiny & Aya M. Hussein. (2019) Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats. Molecular Biology Reports 46:4, pages 3701-3711.
Crossref
Chen Hou, Weimin Zhang, Jianke Li, Lin Du, Ou Lv, Shengjuan Zhao & Jia Li. (2019) Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders. Molecular Nutrition & Food Research 63:16, pages 1800773.
Crossref
Yaser Khajebishak, Laleh Payahoo, Mohammadreza Alivand & Beitollah Alipour. (2018) Punicic acid: A potential compound of pomegranate seed oil in Type 2 diabetes mellitus management. Journal of Cellular Physiology 234:3, pages 2112-2120.
Crossref
Michael Adu‐Frimpong, Caleb Kesse Firempong, Emmanuel Omari‐Siaw, Qilong Wang, Yusif Mohammed Mukhtar, Wenwen Deng, Qingtong Yu, Ximing Xu & Jiangnan Yu. (2018) Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol‐bound punicic acid for increased antihepatotoxic activity. Drug Development Research 80:2, pages 230-245.
Crossref
Yaser Khajebishak, Laleh Payahoo, Hamed Hamishehkar, Mohammadreza Alivand, Mahdieh Alipour, Mohammad Solhi & Beitullah Alipour. (2019) Effect of pomegranate seed oil on the expression of PPAR-γ and pro-inflammatory biomarkers in obese type 2 diabetic patients. Nutrition & Food Science ahead-of-print:ahead-of-print.
Crossref
Luis Vázquez, Marta Corzo-Martínez, Pablo Arranz-Martínez, Elvira Barroso, Guillermo Reglero & Carlos Torres. 2019. Bioactive Molecules in Food. Bioactive Molecules in Food 467 527 .
Michael Adu‐Frimpong, Emmanuel Omari‐Siaw, Yusif Mohammed Mukhtar, Ximing Xu & Jiangnan Yu. (2018) Formulation of Pomegranate Seed Oil: A Promising Approach of Improving Stability and Health‐Promoting Properties. European Journal of Lipid Science and Technology 120:12, pages 1800177.
Crossref
Lin Du, Jianke Li, Xitong Zhang, Lifang Wang & Weimin Zhang. (2018) Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of MAPKs activation. Journal of Functional Foods 43, pages 62-69.
Crossref
Mohamed R. Ben Khedher, Mohamed Hammami, Jonathan R.S. Arch, David C. Hislop, Dominic Eze, Edward T. Wargent, Małgorzata A. Kępczyńska & Mohamed S. Zaibi. (2018) Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone . PeerJ 6, pages e4166.
Crossref
Luis Vázquez, Marta Corzo-Martínez, Pablo Arranz-Martínez, Elvira Barroso, Guillermo Reglero & Carlos Torres. 2017. Sweeteners. Sweeteners 1 61 .
Muhmmad Asim Shabbir, Moazzam Rafiq Khan, Muhammad Saeed, Imran Pasha, Anees Ahmed Khalil & Naila Siraj. (2017) Punicic acid: A striking health substance to combat metabolic syndromes in humans. Lipids in Health and Disease 16:1.
Crossref
Zahra Amri, Asma Ghorbel, Mouna Turki, Férièle Messadi Akrout, Fatma Ayadi, Abdelfateh Elfeki & Mohamed Hammami. (2017) Effect of pomegranate extracts on brain antioxidant markers and cholinesterase activity in high fat-high fructose diet induced obesity in rat model. BMC Complementary and Alternative Medicine 17:1.
Crossref
Ramin Ghorbanzadeh & Karamatollah Rezaei. (2017) Optimization of an Aqueous Extraction Process for Pomegranate Seed Oil. Journal of the American Oil Chemists' Society 94:12, pages 1491-1501.
Crossref
Patricia Lucio Alves, Fernando Mauricio Francis Abdalla, Rafaela Fadoni Alponti & Paulo Flavio Silveira. (2017) Anti-obesogenic and hypolipidemic effects of a glucagon-like peptide-1 receptor agonist derived from the saliva of the Gila monster. Toxicon 135, pages 1-11.
Crossref
Francesca Danesi & Lynnette Ferguson. (2017) Could Pomegranate Juice Help in the Control of Inflammatory Diseases?. Nutrients 9:9, pages 958.
Crossref
Richard G. Peterson, Charles Van Jackson, Karen M. Zimmerman, Jorge Alsina-Fernandez, M. Dodson Michael, Paul J. Emmerson & Tamer Coskun. (2017) Glucose dysregulation and response to common anti-diabetic agents in the FATZO/Pco mouse. PLOS ONE 12:6, pages e0179856.
Crossref
Soudamini Mohapatra & Lekha S.. (2016) Residue level and dissipation of carbendazim in/on pomegranate fruits and soil. Environmental Monitoring and Assessment 188:7.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.