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Ophthalmic Paediatrics and Genetics Volume 7, 1986 - Issue 3
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Original Article

Macular corneal dystrophy Lack of keratan sulfate in serum and cornea

Gordon K. Klintworth Departments of Ophthalmology and Pathology, Duke University Medical Center, Durham, NC
,
Roger Meyer Department of Ophthalmology, University of Michigan, Ann Arbor, MI
,
Richard Dennis Departments of Ophthalmology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
,
A. Tyl Hewitt Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
,
E. Lee Stock Department of Ophthalmology, Northwestern University Medical School, Chicago, IL
,
Mary Ellen Lenz Departments of Biochemistry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
,
John R. Hassell Laboratory of Developmental Biology and Anomalies, NIH, Bethesda, MD
,
Walter J. Stark Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
,
Klaus E. Kuettner Departments of Biochemistry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
&
Eugene J.-M. A. Thonar Departments of Biochemistry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
 show all
Pages 139-143 | Published online: 08 Jul 2009

Citations (35)

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Ahmad AlAraj, Ahmad AlAmeer & Samar Al-Swailem. (2021) Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy. Clinical Ophthalmology 15, pages 3139-3145.
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Barbara P. Palka, Chie Sotozono, Hidetoshi Tanioka, Tomoya O. Akama, Naoto Yagi, Craig Boote, Robert D. Young, Keith M. Meek, Shigeru Kinoshita & Andrew J. Quantock. (2010) Structural Collagen Alterations in Macular Corneal Dystrophy Occur Mainly in the Posterior Stroma. Current Eye Research 35:7, pages 580-586.
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Andrew J. Quantock, Keith M. Meek, Alan E.A. Ridgway, Anthony J. Bron & Eugene J.-M.A. Thonar. (1990) Macular corneal dystrophy: reduction in both corneal thickness and collagen interfibrillar spacing. Current Eye Research 9:4, pages 393-398.
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Articles from other publishers (32)

Anna Hovakimyan. 2022. Medical Atlas of Cornea and External Diseases in Middle Eastern Populations. Medical Atlas of Cornea and External Diseases in Middle Eastern Populations 251 264 .
Glenn C. Cockerham, Kenneth R. Kenyon & Peter S. Hersh. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 555 643 .
Glenn C. Cockerham, Kenneth R. Kenyon & Peter S. Hersh. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology 1 89 .
Michelle Scarritt, Mark Murdock & Stephen F. Badylak. 2019. Principles of Regenerative Medicine. Principles of Regenerative Medicine 613 626 .
Shruti Aggarwal, Travis Peck, Jeffrey Golen & Zeynel A. Karcioglu. (2018) Macular corneal dystrophy: A review. Survey of Ophthalmology 63:5, pages 609-617.
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Jian Wu, Jelena Rnjak-Kovacina, Yiqin Du, Martha L. Funderburgh, David L. Kaplan & James L. Funderburgh. (2014) Corneal stromal bioequivalents secreted on patterned silk substrates. Biomaterials 35:12, pages 3744-3755.
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I. Cretu, D. Brémond-Gignac, S. Milazzo, B. Jany, J.-F. Ikoli, H. Copin & H. Sevestre. (2012) Dystrophie maculaire de Grœnouw II : à propos d’un cas. Journal Français d'Ophtalmologie 35:10, pages 786-791.
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Ji Myung LeeKyu Yeon HwangHo Sik HwangMan Soo Kim. (2012) Long Term Clinical Results of Penetrating Keratoplasty for Macular Corneal Dystrophy. Journal of the Korean Ophthalmological Society 53:10, pages 1425.
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S. Akhtar, A. J. Bron, A. J. Hayes, K. M. Meek & B. Caterson. (2010) Role of keratan sulphate (sulphated poly -N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 249:3, pages 413-420.
Crossref
Luciene B. De Sousa & Mark J. Mannis. 2011. Cornea. Cornea 823 844 .
Gordon K Klintworth. (2009) Corneal dystrophies. Orphanet Journal of Rare Diseases 4:1.
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Kenneth R. Kenyon, Tomy Starck, Glen Cockerham & Peter S. Hersh. 2008. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology 497 551 .
Saul Merin. 2005. Inherited Eye Diseases. Inherited Eye Diseases 29 99 .
Samar A. Al-Swailem, Ali A. Al-Rajhi & Michael D. Wagoner. (2005) Penetrating keratoplasty for macular corneal dystrophy. Ophthalmology 112:2, pages 220-224.
Crossref
Minoru Fukuda, Nobuyoshi Hiraoka, Tomoya O. Akama & Michiko N. Fukuda. (2001) Carbohydrate-modifying Sulfotransferases: Structure, Function, and Pathophysiology. Journal of Biological Chemistry 276:51, pages 47747-47750.
Crossref
C Cursiefen, C Hofmann-Rummelt, U Schlötzer-Schrehardt, D.-C Fischer, H.-D Haubeck, M Küchle & G.O.H Naumann. (2001) Immunohistochemical Classification of Primary and Recurrent Macular Corneal Dystrophy in Germany: Subclassification of Immunophenotype I A Using a Novel Keratan Sulfate Antibody. Experimental Eye Research 73:5, pages 593-600.
Crossref
Anna H. Plaas, Leigh A. West, Eugene J.A. Thonar, Zeynel A. Karcioglu, Clayton J. Smith, Gordon K. Klintworth & Vincent C. Hascall. (2001) Altered Fine Structures of Corneal and Skeletal Keratan Sulfate and Chondroitin/Dermatan Sulfate in Macular Corneal Dystrophy. Journal of Biological Chemistry 276:43, pages 39788-39796.
Crossref
Kyu Sik Kim, Ja Young Lee, Sung Kun Chung & Nam Ho Baek. (2001) Corneal opacity after repeated photorefractive keratectomy. Journal of Cataract and Refractive Surgery 27:7, pages 1128-1131.
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Tomoya O. Akama, Jun Nakayama, Kohji Nishida, Nobuyoshi Hiraoka, Misa Suzuki, Joseph McAuliffe, Ole Hindsgaul, Minoru Fukuda & Michiko N. Fukuda. (2001) Human Corneal GlcNAc 6-O-Sulfotransferase and Mouse Intestinal GlcNAc 6-O-Sulfotransferase Both Produce Keratan Sulfate. Journal of Biological Chemistry 276:19, pages 16271-16278.
Crossref
Tomoya O. Akama, Kohji Nishida, Jun Nakayama, Hitoshi Watanabe, Kouichi Ozaki, Takahiro Nakamura, Atsuyoshi Dota, Satoshi Kawasaki, Yoshitsugu Inoue, Naoyuki Maeda, Shuji Yamamoto, Tsutomu Fujiwara, Eugene J.-M.A. Thonar, Yoshikazu Shimomura, Shigeru Kinoshita, Akira Tanigami & Michiko N. Fukuda. (2000) Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. Nature Genetics 26:2, pages 237-241.
Crossref
James Funderburgh. 2000. Proteoglycans. Proteoglycans.
Shukti Chakravarti, Terry Magnuson, Jonathan H. Lass, Karl J. Jepsen, Christian LaMantia & Heidi Carroll. (1998) Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican. The Journal of Cell Biology 141:5, pages 1277-1286.
Crossref
GORDON K. KLINTWORTH, ERI OSHIMA, A. AL-RAJHI, A. AL-SAIF, EUGENE J.-M.A. THONAR & ZEYNEL A. KARCIOGLU. (1997) Macular Corneal Dystrophy in Saudi Arabia: A Study of 56 Cases and Recognition of a New Immunophenotype. American Journal of Ophthalmology 124:1, pages 9-18.
Crossref
Andrew J Quantock, Nigel J Fullwood, Eugene J -M A Thonar, Stephen R Waltman, Malcolm S Capel, Mitsutoshi Ito, Steven M Verity & David J Schanzlin. (1997) Macular corneal dystrophy type II: Multiple studies on a cornea with low levels of sulphated keratan sulphate. Eye 11:1, pages 57-67.
Crossref
Fridbert Jonasson, Eri Oshima, Eugene J-M. A. Thonar, Clayton F. Smith, Johann H. Johannsson & Cordon K. Klintworth. (1996) Macular Corneal Dystrophy in Iceland. Ophthalmology 103:7, pages 1111-1117.
Crossref
Andrew J. Quantock. (2014) An erroneous glycosaminoglycan metabolism leads to corneal opacification in macular corneal dystrophy. Glycosylation & Disease 1:3, pages 143-151.
Crossref
Andrew J Quantock, Keith M Meek, Eugene J-M A Thonar & Kerry K Assil. (1993) Synchrotron X-ray diffraction in atypical macular dystrophy. Eye 7:6, pages 779-784.
Crossref
A.J. Quantock, K.M. Meek, P. Brittain, A.E.A. Ridgway & E.J.-M.A. Thonar. (1991) Alteration of the stromal architecture and depletion of keratan sulphate proteoglycans in oedematous human corneas: Histological, immunochemical and x-ray diffraction evidence. Tissue and Cell 23:5, pages 593-606.
Crossref
Elaine R. BermanElaine R. Berman. 1991. Biochemistry of the Eye. Biochemistry of the Eye 89 150 .
Deepak P. Edward, Eugene J.-M.A. Thonar, M. Srinivasan, Beatrice J.Y.T. Yue & Mark O.M. Tso. (1990) Macular Dystrophy of the Cornea. Ophthalmology 97:9, pages 1194-1200.
Crossref
Keith M. Meek, Andrew J. Quantock, Gerald F. Elliott, Alan E.A. Ridgway, Andrew B. Tullo, Anthony J. Bron & Eugene J.-M.A. Thonar. (1989) Macular corneal dystrophy: The macromolecular structure of the stroma observed using electron microscopy and synchrotron X-ray diffraction. Experimental Eye Research 49:6, pages 941-958.
Crossref
C. Julia Yang, Nirmala SundarRaj, J.-M. Eugene, A. Thonar & Gordon K. Klintworth. (1988) Immunohistochemical Evidence of Heterogeneity in Macular Corneal Dystrophy. American Journal of Ophthalmology 106:1, pages 65-71.
Crossref

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