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Research Article

Antimycobacterial activity of usnic acid against resistant and susceptible strains of Mycobacterium tuberculosis and non-tuberculous mycobacteria

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Pages 260-263 | Received 27 Jul 2008, Accepted 09 Apr 2009, Published online: 20 Jan 2010

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Olga A. Luzina & Nariman F. Salakhutdinov. (2018) Usnic acid and its derivatives for pharmaceutical use: a patent review (2000–2017). Expert Opinion on Therapeutic Patents 28:6, pages 477-491.
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A. A. S. Araújo, M. G. D. de Melo, T. K. Rabelo, P. S. Nunes, S. L. Santos, M. R. Serafini, M. R. V. Santos, L. J. Quintans-Júnior & D. P. Gelain. (2015) Review of the biological properties and toxicity of usnic acid. Natural Product Research 29:23, pages 2167-2180.
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Articles from other publishers (31)

Cristina Chircov, Alexandra Cătălina Bîrcă, Lorena Alexandra Dănciulescu, Ionela Andreea Neacșu, Ovidiu-Cristian Oprea, Roxana-Doina Trușcă & Ecaterina Andronescu. (2023) Usnic Acid-Loaded Magnetite Nanoparticles—A Comparative Study between Synthesis Methods. Molecules 28:13, pages 5198.
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Hanxue Wang, Min Xuan, Juanjuan Diao, Nan Xu, Manlin Li, Cheng Huang & Changhong Wang. (2023) Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method. Frontiers in Pharmacology 14.
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Hanxue Wang, Min Xuan, Cheng Huang & Changhong Wang. (2022) Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo. Molecules 27:21, pages 7469.
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Nicoletta Croce, Michele Pitaro, Valentina Gallo & Giovanni Antonini. (2022) Toxicity of Usnic Acid: A Narrative Review. Journal of Toxicology 2022, pages 1-12.
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Himanshu Rai, Rajan Kumar Gupta, Devvret Verma, Shreesh Gupta, Debasis Mitra, Pradeep Kumar Das Mohapatra, Areej Suliman Al-Meshal, Rokayya Sami, Amal Adnan Ashour & Alaa Shafie. (2022) Assessment of Antimicrobial Activity of Lichenic Compounds Isolated from Menegazzia terebrata (Hoffm.) A. Massal . Journal of Biobased Materials and Bioenergy 16:3, pages 418-423.
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Livia da Silva FreitasCarolina da Silva Canielles CapraraLisiane Martins VolcãoRodrigo de Lima Brum, Israel BarbosaFlávio Manoel Rodrigues da SilvaJr.Jr. & Daniela Fernandes Ramos. (2022) Usnic Acid (+) Enantiomer in Alternative In Vitro Control of Burkholderia cepacia and Allelopathic Effect . Applied In Vitro Toxicology 8:2, pages 58-63.
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Taciana Lima Salviano, Daniel Charles dos Santos Macedo, Rafaela de Siqueira Ferraz Carvalho, Marcela Araújo Pereira, Vanessa Santos de Arruda Barbosa, Jaciana dos Santos Aguiar, Fabrício Oliveira Souto, Maria da Paz Carvalho da Silva, Lílian Maria Lapa Montenegro Pimentel, Luanna de Ângelis Correia de Sousa, Bezerra Sidicleia Costa Silva, Teresinha Gonçalves da Silva, Alexandre José da Silva Góes, Nereide Stela Santos Magalhães & Mariane Cajubá de Britto Lira Nogueira. (2021) Fucoidan-Coated Liposomes: A Target System to Deliver the Antimicrobial Drug Usnic Acid to Macrophages Infected with Mycobacterium tuberculosis . Journal of Biomedical Nanotechnology 17:8, pages 1699-1710.
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Elwira Sieniawska, Rafal Sawicki, Wieslaw Truszkiewicz, Andrey S. Marchev & Milen I. Georgiev. (2021) Usnic Acid Treatment Changes the Composition of Mycobacterium tuberculosis Cell Envelope and Alters Bacterial Redox Status. mSystems 6:3.
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D. C. S. Macedo, F. J. F. Almeida, M. S. O. Wanderley, M. S. Ferraz, N. P. S. Santos, A. M. Q. López, N. S. Santos-Magalhães & M. C. B. Lira-Nogueira. (2020) Usnic acid: from an ancient lichen derivative to promising biological and nanotechnology applications. Phytochemistry Reviews 20:3, pages 609-630.
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Asghar Sepahvand, Elżbieta Studzińska-Sroka, Parvin Ramak & Vahid Karimian. (2021) Usnea sp.: Antimicrobial potential, bioactive compounds, ethnopharmacological uses and other pharmacological properties; a review article. Journal of Ethnopharmacology 268, pages 113656.
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Moritz Rauschenbach, Stefan B. Lawrenson, Vincenzo Taresco, Amanda K. Pearce & Rachel K. O'Reilly. (2020) Antimicrobial Hyperbranched Polymer–Usnic Acid Complexes through a Combined ROP‐RAFT Strategy. Macromolecular Rapid Communications 41:18, pages 2000190.
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Laura Rindi. (2020) Efflux Pump Inhibitors against Nontuberculous Mycobacteria. International Journal of Molecular Sciences 21:12, pages 4191.
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Shraddha Pandey, Shashi K. Misra & Nisha Sharma. (2020) Development of Usnic Acid Embedded Eudragit Microspheres for Alleviation of Nosocomial Infections. Anti-Infective Agents 18:1, pages 79-87.
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Veronika Kuhn, Thomas Geisberger, Claudia Huber, Andreas Beck & Wolfgang Eisenreich. (2019) A facile in vivo procedure to analyze metabolic pathways in intact lichens . New Phytologist 224:4, pages 1657-1667.
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Agnieszka Galanty, Paweł Paśko & Irma Podolak. (2019) Enantioselective activity of usnic acid: a comprehensive review and future perspectives. Phytochemistry Reviews 18:2, pages 527-548.
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Marijana Kosanić & Branislav Ranković. 2019. Lichen Secondary Metabolites. Lichen Secondary Metabolites 99 127 .
Branislav Ranković & Marijana Kosanić. 2019. Lichen Secondary Metabolites. Lichen Secondary Metabolites 1 29 .
Daniela Cirillo, Emanuele Borroni, Irene Festoso, Diego Monti, Sergio Romeo, Dominique Mazier & Luisella Verotta. (2018) Synthesis and antimycobacterial activity of (+)-usnic acid conjugates. Archiv der Pharmazie 351:12, pages 1800177.
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Lili FitrianiIrma AfriyantiAfriyani AfriyaniFriardi IsmedErizal Zaini. (2018) Solid Dispersion of Usnic acid–HPMC 2910 Prepared by Spray drying and Freeze drying Techniques. Oriental Journal of Chemistry 34:4, pages 2083-2088.
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Kartsev Victor, Lichitsky Boris, Geronikaki Athina, Petrou Anthi, Smiljkovic Marija, Kostic Marina, Radanovic Oliver & Soković Marina. (2018) Design, synthesis and antimicrobial activity of usnic acid derivatives. MedChemComm 9:5, pages 870-882.
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Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang & Changhong Wang. (2018) Simultaneous determination of usnic, diffractaic, evernic and barbatic acids in rat plasma by ultra-high-performance liquid chromatography-quadrupole exactive Orbitrap mass spectrometry and its application to pharmacokinetic studies. Biomedical Chromatography 32:3, pages e4123.
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Rafaela S Ferraz-Carvalho, Marcela A Pereira, Leonardo A Linhares, Mariane CB Lira-Nogueira, Isabella MF Cavalcanti, Nereide S Santos-Magalhães & Lílian ML Montenegro. (2016) Effects of the encapsulation of usnic acid into liposomes and interactions with antituberculous agents against multidrug-resistant tuberculosis clinical isolates. Memórias do Instituto Oswaldo Cruz 111:5, pages 330-334.
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O. A. Luzina & N. F. Salakhutdinov. (2016) Biological activity of usnic acid and its derivatives: Part 1. Activity against unicellular organisms. Russian Journal of Bioorganic Chemistry 42:2, pages 115-132.
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AA Shtro, VV Zarubaev, OA Luzina, DN Sokolov & NF Salakhutdinov. (2016) Derivatives of usnic acid inhibit broad range of influenza viruses and protect mice from lethal influenza infection. Antiviral Chemistry and Chemotherapy 24:3-4, pages 92-98.
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Marijana Kosanić & Branislav Ranković. 2015. Lichen Secondary Metabolites. Lichen Secondary Metabolites 81 104 .
Branislav Ranković & Marijana Kosanić. 2015. Lichen Secondary Metabolites. Lichen Secondary Metabolites 1 26 .
Anna A. Shtro, Vladimir V. Zarubaev, Olga A. Luzina, Dmitry N. Sokolov, Oleg I. Kiselev & Nariman F. Salakhutdinov. (2014) Novel derivatives of usnic acid effectively inhibiting reproduction of influenza A virus. Bioorganic & Medicinal Chemistry 22:24, pages 6826-6836.
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Andrea Martinelli, Ahmed Bakry, Lucio D’Ilario, Iolanda Francolini, Antonella Piozzi & Vincenzo Taresco. (2014) Release behavior and antibiofilm activity of usnic acid-loaded carboxylated poly(l-lactide) microparticles. European Journal of Pharmaceutics and Biopharmaceutics 88:2, pages 415-423.
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Ina L. LauingerLivia VivasRemo Perozzo, Christopher Stairiker, Alice Tarun, Mire ZlohXujie Zhang, Hua Xu, Peter J. Tonge, Scott G. Franzblau, Duc-Hung Pham, Camila V. Esguerra, Alexander D. Crawford, Louis Maes & Deniz Tasdemir. (2013) Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target . Journal of Natural Products 76:6, pages 1064-1070.
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Iolanda Francolini, Vincenzo Taresco, Fernanda Crisante, Andrea Martinelli, Lucio D'Ilario & Antonella Piozzi. (2013) Water Soluble Usnic Acid-Polyacrylamide Complexes with Enhanced Antimicrobial Activity against Staphylococcus epidermidis. International Journal of Molecular Sciences 14:4, pages 7356-7369.
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Qian Liu, Xiaoping Zhao, Xiaoyan Lu, Xiaohui Fan & Yi Wang. (2012) Proteomic Study on Usnic-Acid-Induced Hepatotoxicity in Rats. Journal of Agricultural and Food Chemistry 60:29, pages 7312-7317.
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