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Pharmaceutical Biology Volume 49, 2011 - Issue 5
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Research Article

Ginsenoside Rg1 protects primary cultured rat hippocampal neurons from cell apoptosis induced by β-amyloid protein

Li GongDepartment of Traditional Chinese Integrated Western Medicine Qilu Hospital of Shandong University, Jinan, Shandong
,
Shu-Ling LiDepartment of Traditional Chinese Integrated Western Medicine Qilu Hospital of Shandong University, Jinan, ShandongCorrespondence[email protected]
,
Hui LiMedical Department, Dezhou University, Dezhou, Shandong P.R. China
&
Lei ZhangDepartment of Neurosurgery General Hospital of Jinan Military Area Command of Chinese PLA, Jinan, Shandong P.R. China.
Pages 501-507 | Received 11 Apr 2010, Accepted 02 Sep 2010, Published online: 26 Mar 2011

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Fangfei Liu, Yating Shen, Jiabin Li, Lixia Bi, Xiaoli Ye, Yanhong Li & Du Zhi. (2023) Characteristics of ginsenoside Rd-induced effects on rat intestinal contractility with irritable bowel syndrome. Natural Product Research 37:18, pages 3152-3157.
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Mohammad Reza Tabandeh, Hadis Jafari, Seyed Ahmad Hosseini & Mahmod Hashemitabar. (2015) Ginsenoside Rb1 stimulates adiponectin signaling in C2C12 muscle cells through up-regulation of AdipoR1 and AdipoR2 proteins. Pharmaceutical Biology 53:1, pages 125-132.
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Dapeng Chen, Yongjian Xiong, Chunling Jiang, Bochao Lv, Fangfei Liu, Li Wang & Yuan Lin. (2014) Effects of ginsenosides on rat jejunal contractility. Pharmaceutical Biology 52:2, pages 162-168.
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Nan Li, Yu-han Duan, Lei Chen & Kun Zhang. (2023) Iron metabolism: An emerging therapeutic target underlying the anti-Alzheimer's disease effect of ginseng. Journal of Trace Elements in Medicine and Biology 79, pages 127252.
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Alev Duygu Acun, Deniz Kantar, Hakan Er, Orhan Erkan, Narin Derin & Piraye Yargıcoglu. (2023) Investigation of Cyclo-Z Therapeutic Effect on Insulin Pathway in Alzheimer's Rat Model: Biochemical and Electrophysiological Parameters. Molecular Neurobiology 60:7, pages 4030-4048.
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Zhiqiang Xu, Xue Li, Guodong Shen, Yunxuan Zou, Hongning Zhang, Kangyong Yang & Yongzhan Zhu. (2022) The Protective Effect of Ginsenoside Rg1 on Apoptosis in Human Ankle Joint Traumatic Arthritis Chondrocytes. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-7.
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Jing Lu, Xian Wang, Anxin Wu, Yi Cao, Xiaolin Dai, Youdan Liang & Xiaofang Li. (2022) Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics. Phytotherapy Research 36:4, pages 1523-1544.
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Edward J. Calabrese. (2020) Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects. Molecules 25:11, pages 2719.
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Li Gao, Feng Zhou, Ke-xin Wang, Yu-zhi Zhou, Guan-hua Du & Xue-mei Qin. (2020) Baicalein protects PC12 cells from Aβ25–35-induced cytotoxicity via inhibition of apoptosis and metabolic disorders. Life Sciences 248, pages 117471.
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Enis Hidisoglu & Piraye Yargicoglu. (2020) Auditory evoked potentials might have the potential to serve as early indicators related to amyloid beta peptide toxicity. Advances in Medical Sciences 65:1, pages 223-232.
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Miriama Simunkova, Saleh H. Alwasel, Ibrahim M. Alhazza, Klaudia Jomova, Vojtech Kollar, Miroslav Rusko & Marian Valko. (2019) Management of oxidative stress and other pathologies in Alzheimer’s disease. Archives of Toxicology 93:9, pages 2491-2513.
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Yujuan Li, Bingmei Wang, Cong Liu, Xiaoting Zhu, Pengqi Zhang, Hongkui Yu, Yunqiang Li, Zhuohan Li & Mingquan Li. (2019) Inhibiting c-Jun N-terminal kinase (JNK)-mediated apoptotic signaling pathway in PC12 cells by a polysaccharide (CCP) from Coptis chinensis against Amyloid-β (Aβ)-induced neurotoxicity. International Journal of Biological Macromolecules 134, pages 565-574.
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Ge Li, Ning Zhang, Fang Geng, Guoliang Liu, Bin Liu, Xia Lei, Guang Li & Xi Chen. (2019) High-throughput metabolomics and ingenuity pathway approach reveals the pharmacological effect and targets of Ginsenoside Rg1 in Alzheimer’s disease mice. Scientific Reports 9:1.
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Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Xiaokui Huo, Zhihao Liu, Huijun Sun, Xiaobo Yang, Pengyuan Sun, Xiaodong Ma, Qiang Meng & Kexin Liu. (2018) Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride‐induced acute liver injury by activating Nrf2 signaling pathway in mice . Environmental Toxicology 33:10, pages 1050-1060.
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Enis Hidisoglu, Deniz Kantar‐Gok, Hakan Er, Alev Duygu Acun & Piraye Yargicoglu. (2018) Alterations in spontaneous delta and gamma activity might provide clues to detect changes induced by amyloid‐β administration. European Journal of Neuroscience 47:8, pages 1013-1023.
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Seo-Yun Choi, Kui-Jin Kim, Ji-Hyeon Song & Boo-Yong Lee. (2018) Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells. Journal of Ginseng Research 42:2, pages 225-228.
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Lulin Nie, Junxia Xia, Honglian Li, Zaijun Zhang, Ying Yang, Xinfeng Huang, Zhendan He, Jianjun Liu & Xifei Yang. (2017) Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity 2017, pages 1-17.
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JUNZHENG HU, YANQING GU & WEIMIN FAN. (2016) Rg1 protects rat bone marrow stem cells against hydrogen peroxide-induced cell apoptosis through the PI3K/Akt pathway. Molecular Medicine Reports 14:1, pages 406-412.
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Qian-kun Quan, Xi Li, Hai-feng Yuan, Yi Wang & Wen-li Liu. (2016) Ginsenoside Rg1 inhibits high-voltage-activated calcium channel currents in hippocampal neurons of beta-amyloid peptide-exposed rat brain slices. Chinese Journal of Integrative Medicine.
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Zhi-Yong Wang, Jian-Gang Liu, Hao Li & Hui-Ming Yang. (2016) Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review. The American Journal of Chinese Medicine 44:08, pages 1525-1541.
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An-Sik Chung & Kyeong Mee Park. 2016. 131 158 .
Bao-Ying Hu, Xian-Jin Liu, Ren Qiang, Zheng-Lin Jiang, Li-Hua Xu, Guo-Hua Wang, Xia Li & Bin Peng. (2014) Treatment with ginseng total saponins improves the neurorestoration of rat after traumatic brain injury. Journal of Ethnopharmacology 155:2, pages 1243-1255.
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Yumin Huang, Dongying Wu & Weimin Fan. (2014) Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Akt signaling. Molecular and Cellular Biochemistry 392:1-2, pages 249-257.
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WEI-XU HU, QIN XIANG, ZHU WEN, DAN HE, XIAO-MU WU & GUO-ZHU HU. (2014) Neuroprotective effect of Atractylodes macrocephalaon polysaccharides in vitro on neuronal apoptosis induced by hypoxia. Molecular Medicine Reports 9:6, pages 2573-2581.
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Imogen Smith, Elizabeth M Williamson, Sophie Putnam, Jonathan Farrimond & Benjamin J Whalley. (2014) Effects and mechanisms of ginseng and ginsenosides on cognition. Nutrition Reviews 72:5, pages 319-333.
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Xiao-Wen Zhou, Zheng Zhang, Chao-Fen Su, Ruo-Hua Lv, Xing Zhou, Liang Cai, Chen-Yu Wang, Li Yan, Wei Zhang & Huan-Min Luo. (2013) Methyl 3,4-dihydroxybenzoate protects primary cortical neurons against Aβ 25-35 -induced neurotoxicity through mitochondria pathway . Journal of Neuroscience Research 91:9, pages 1215-1225.
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Xiaomin Hou, Chunsheng Li, Wei Gu, Zhijun Guo, Wenpeng Yin & Da Zhang. (2013) Effect of Shenfu on inflammatory cytokine release and brain edema after prolonged cardiac arrest in the swine. The American Journal of Emergency Medicine 31:8, pages 1159-1164.
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Wen-Fang Chen, Li-Ping Zhou, Lei Chen, Lin Wu, Quan-Gui Gao & Man-Sau Wong. (2013) Involvement of IGF-I receptor and estrogen receptor pathways in the protective effects of ginsenoside Rg1 against Aβ25–35-induced toxicity in PC12 cells. Neurochemistry International 62:8, pages 1065-1071.
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QianKun Quan, Jue Wang, Xi Li & Yi Wang. (2013) Ginsenoside Rg1 Decreases Aβ1–42 Level by Upregulating PPARγ and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease. PLoS ONE 8:3, pages e59155.
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Wei Li, Yanqi Chu, Lan Zhang, Linlin Yin & Lin Li. (2012) Ginsenoside Rg1 prevents SK-N-SH neuroblastoma cell apoptosis induced by supernatant from Aβ1–40-stimulated THP-1 monocytes. Brain Research Bulletin 88:5, pages 501-506.
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Suresh Kumar, Edward J. Okello & J. Robin Harris. 2012. Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease. Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease 295 326 .

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