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Pharmaceutical Biology Volume 50, 2012 - Issue 12
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Research Article

In vitro and in vivo anticancer properties of cucurbitacin isolated from Cayaponia racemosa

Gardenia C. G. MilitãoDepartamento de Fisiologia e Farmacologia da Universidade Federal de Pernambuco. Rua prof. Moraes Rego, Cidade Universitária, Recife, PE, BrasilCorrespondence[email protected]
,
Ivana N. F. DantasDepartamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Rua Cel. Nunes de Melo, Fortaleza, CE, Brasil
,
Paulo Michel P. FerreiraDepartamento de Ciências Biológicas, Campus Senador Helvídio Nunes de Barros (CSHNB), Universidade Federal do Piauí, Rua Cícero Eduardo, s/n – Bairro Junco, Picos, Piauí, Brasil
,
Ana Paula N. N. AlvesDepartamento de Clínica Odontológica, Universidade Federal do Ceará, Rua Monsenhor Furtado s/n, Fortaleza, CE, Brasil
,
Davina C. ChavesCampus José Doca, Instituto Federal de Educação Ciência e Tecnologia do Maranhão, Zé Doca-MA
,
Francisco José Q. MonteDepartamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, CE, Brasil
,
Cláudia PessoaDepartamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Rua Cel. Nunes de Melo, Fortaleza, CE, Brasil
,
Manoel Odorico de MoraesDepartamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Rua Cel. Nunes de Melo, Fortaleza, CE, Brasil
&
Letícia V. Costa-LotufoDepartamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Rua Cel. Nunes de Melo, Fortaleza, CE, Brasil
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Pages 1479-1487 | Received 23 Feb 2012, Accepted 10 Apr 2012, Published online: 11 Sep 2012

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Camila dos Reis Oliveira, Joedna Cavalcante Pereira, Andressa Barros Ibiapina, Italo Rossi Roseno Martins, João Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira & Felipe Cavalcanti Carneiro da Silva. (2023) Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies. Journal of Toxicology and Environmental Health, Part B 26:8, pages 417-441.
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Articles from other publishers (14)

Yalew Yiblet. 2023. Biological and Abiotic Stress in Cucurbitaceae Crops. Biological and Abiotic Stress in Cucurbitaceae Crops.
Paulo Michel Pinheiro Ferreira, Renata Rosado Drumond, Jurandy do Nascimento Silva, Ian Jhemes Oliveira Sousa, Marcus Vinicius Oliveira Barros de Alencar, Ana Maria Oliveira Ferreira da Mata, Nayana Bruna Nery Monção, Antonia Maria das Graças Lopes Citó, Ana Fontenele Urano Carvalho, Davi Felipe Farias, Patrícia Marçal da Costa, Adriana Maria Viana Nunes, João Marcelo de Castro e Sousa & Ana Amélia de Carvalho Melo-Cavalcante. (2021) Chemotherapeutic and Safety Profile of a Fraction from Mimosa caesalpiniifolia Stem Bark. Journal of Oncology 2021, pages 1-12.
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Yamil Liscano, Jose Oñate-Garzón & Jean Paul Delgado. (2020) Peptides with Dual Antimicrobial–Anticancer Activity: Strategies to Overcome Peptide Limitations and Rational Design of Anticancer Peptides. Molecules 25:18, pages 4245.
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Parichat Suebsakwong, Jie Wang, Phorntip Khetkam, Natthida Weerapreeyakul, Jing Wu, Yun Du, Zhu-Jun Yao, Jian-Xin Li & Apichart Suksamrarn. (2019) A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model. ACS Medicinal Chemistry Letters 10:10, pages 1400-1406.
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Carlos Alberto Méndez-Cuesta, Ana Laura Esquivel Campos, David Salinas Sánchez, Cuauhtemoc Pérez González & Salud Pérez Gutiérrez. 2019. Pharmacognosy - Medicinal Plants. Pharmacognosy - Medicinal Plants.
Siva Prasad Panda, Bikash Ranjan Jena, Gade Kalyani & Uttam Prasad Panigrahy. (2018) Overexpressed CYP450 mediated apoptosis evaluates cytotoxicity and teratotoxicity of Cucumis callosus. Oriental Pharmacy and Experimental Medicine 18:4, pages 365-375.
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Felipe Finger Banfi, Karla de Sena Guedes, Carla Regina Andrighetti, Ana Carolina Aguiar, Bryan Wender Debiasi, Janaina da Costa Noronha, Domingos de Jesus Rodrigues, Gerardo Magela Vieira Júnior & Bruno Antonio Marinho Sanchez. (2016) Antiplasmodial and Cytotoxic Activities of Toad Venoms from Southern Amazon, Brazil. The Korean Journal of Parasitology 54:4, pages 415-421.
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Paulo Michel Pinheiro Ferreira, Daniel Pereira Bezerra, Jurandy do Nascimento Silva, Marcília Pinheiro da Costa, José Roberto de Oliveira Ferreira, Nylane Maria Nunes Alencar, Ingrid Samantha Tavares de Figueiredo, Alberto José Cavalheiro, Camila Maria Longo Machado, Roger Chammas, Ana Paula Negreiros Nunes Alves, Manoel Odorico de Moraes & Claudia Pessoa. (2016) Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and its component Casearin X: in vivo and ex vivo methods and microscopy examinations. Journal of Ethnopharmacology 186, pages 270-279.
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Patrícia Marçal da Costa, Marcilia Pinheiro da Costa, Adriana Andrade Carvalho, Suellen Melo Tibúrcio Cavalcanti, Marcos Veríssimo de Oliveira Cardoso, Gevânio Bezerra de Oliveira Filho, Daniel de Araújo Viana, Francisco Vagnaldo Fechine-Jamacaru, Ana Cristina Lima Leite, Manoel Odorico de Moraes, Claudia Pessoa & Paulo Michel Pinheiro Ferreira. (2015) Improvement of in vivo anticancer and antiangiogenic potential of thalidomide derivatives. Chemico-Biological Interactions 239, pages 174-183.
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Paulo Michel Pinheiro Ferreira, Gardenia Carmen Gadelha Militão, Daisy Jereissati Barbosa Lima, Nagilla Daniela de Jesus Costa, Kátia da Conceição Machado, André Gonzaga dos Santos, Alberto José Cavalheiro, Vanderlan da Silva Bolzani, Dulce Helena Siqueira Silva & Cláudia Pessoa. (2014) Morphological and biochemical alterations activated by antitumor clerodane diterpenes. Chemico-Biological Interactions 222, pages 112-125.
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Chao-Ming Hung, Chi-Chang Chang, Chen-Wei Lin, Chih-Chen Chen & Yi-Chiang Hsu. (2014) GADD45γ induces G2/M arrest in human pharynx and nasopharyngeal carcinoma cells by cucurbitacin E. Scientific Reports 4:1.
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Davi Felipe Farias, Martônio Ponte Viana, Gustavo Ramos de Oliveira, Magda Aparecida Beneventi, Bruno Marques Soares, Claudia Pessoa, Igor Parra Pessoa, Luciano Paulino Silva, Ilka Maria Vasconcelos, Maria Fátima Grossi de Sá & Ana Fontenele Urano Carvalho. (2014) Evaluation of Cytotoxic and Antimicrobial Effects of Two Bt Cry Proteins on a GMO Safety Perspective . BioMed Research International 2014, pages 1-14.
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Paulo Michel Pinheiro Ferreira, Daisy Jereissati Barbosa Lima, Bryan Wender Debiasi, Bruno Marques Soares, Kátia da Conceição Machado, Janaina da Costa Noronha, Domingos de Jesus Rodrigues, Adilson Paulo Sinhorin, Cláudia Pessoa & Gerardo Magela Vieira Júnior. (2013) Antiproliferative activity of Rhinella marina and Rhaebo guttatus venom extracts from Southern Amazon. Toxicon 72, pages 43-51.
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Lamice Habib, Nathalie Khreich, Alia Jraij, Suzanne Abbas, Jacques Magdalou, Catherine Charcosset & Hélène Greige-Gerges. (2013) Preparation and characterization of liposomes incorporating cucurbitacin E, a natural cytotoxic triterpene. International Journal of Pharmaceutics 448:1, pages 313-319.
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