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Research Article

Induction of apoptosis through tubulin inhibition in human cancer cells by new chromene-based chalcones

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Pages 1551-1560 | Received 03 Oct 2011, Accepted 16 May 2012, Published online: 18 Sep 2012

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Wenjing Liu, Min He, Yongjun Li, Zhiyun Peng & Guangcheng Wang. (2022) A review on synthetic chalcone derivatives as tubulin polymerisation inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 9-38.
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Samina Nazir, Farzana Latif Ansari, Tajammul Hussain, Kehkashan Mazhar, Ambreen Gul Muazzam, Zaheer-ul-Haq Qasmi, Talat Makhmoor, Humera Noureen & Bushra Mirza. (2013) Brine shrimp lethality assay ‘an effective prescreen’: Microwave-assisted synthesis, BSL toxicity and 3DQSAR studies-based designing, docking and antitumor evaluation of potent chalcones. Pharmaceutical Biology 51:9, pages 1091-1103.
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Articles from other publishers (22)

Meng He, Mingjun Yu, Chao Li, Xiaoming Meng, Jiamin Su, Yuting Zhu & Risheng Yao. (2022) Design, Synthesis and Bioactivity Evaluation of Novel Chalcone Derivatives Possessing Tryptophan Moiety with Dual Activities of Anti-Cancer and Partially Restoring the Proliferation of Normal Kidney Cells Pre-Treated with Cisplatin. Anti-Cancer Agents in Medicinal Chemistry 22:10, pages 1945-1961.
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Domenico Iacopetta, Alessia Catalano, Jessica Ceramella, Alexia Barbarossa, Alessia Carocci, Alessia Fazio, Chiara La Torre, Anna Caruso, Marco Ponassi, Camillo Rosano, Carlo Franchini & Maria Stefania Sinicropi. (2020) Synthesis, anticancer and antioxidant properties of new indole and pyranoindole derivatives. Bioorganic Chemistry 105, pages 104440.
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Hassan Mirzaei, Mahdi Abastabar & Saeed Emami. (2020) Indole-derived chalcones as anti-dermatophyte agents: In vitro evaluation and in silico study. Computational Biology and Chemistry 84, pages 107189.
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Fariba Khosravifar, Gholamreza Dehghan, Seyed Kazem Bidoki & Majid Mahdavi. (2019) DNA‐binding activity and cytotoxic and cell‐cycle arrest properties of some new coumarin derivatives: a multispectral and computational investigation. Luminescence 35:1, pages 98-106.
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Mahsa Ansari, Mohammad Shokrzadeh, Saeed Karima, Shima Rajaei, Marjan Fallah, Nasrin Ghassemi-Barghi, Majid Ghasemian & Saeed Emami. (2020) New thiazole-2(3H)-thiones containing 4-(3,4,5-trimethoxyphenyl) moiety as anticancer agents. European Journal of Medicinal Chemistry 185, pages 111784.
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Efraín Polo, Nicol Ibarra-Arellano, Luis Prent-Peñaloza, Alejandro Morales-Bayuelo, José Henao, Antonio Galdámez & Margarita Gutiérrez. (2019) Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors. Bioorganic Chemistry 90, pages 103034.
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Ruchi Verma, Indira Bairy, Mradul Tiwari, G. Varadaraj Bhat & G. Gautham Shenoy. (2018) In silico studies, synthesis and anticancer activity of novel diphenyl ether-based pyridine derivatives. Molecular Diversity 23:3, pages 541-554.
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Malose Mphahlele, Marole Maluleka, Nishal Parbhoo & Sibusiso Malindisa. (2018) Synthesis, Evaluation for Cytotoxicity and Molecular Docking Studies of Benzo[c]furan-Chalcones for Potential to Inhibit Tubulin Polymerization and/or EGFR-Tyrosine Kinase Phosphorylation. International Journal of Molecular Sciences 19:9, pages 2552.
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Adileh Ayati, Tayebeh Oghabi Bakhshaiesh, Setareh Moghimi, Rezvan Esmaeili, Keivan Majidzadeh-A, Maliheh Safavi, Loghman Firoozpour, Saeed Emami & Alireza Foroumadi. (2018) Synthesis and biological evaluation of new coumarins bearing 2,4-diaminothiazole-5-carbonyl moiety. European Journal of Medicinal Chemistry 155, pages 483-491.
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Heather K. Armstrong, Joanna L. Gillis, Ian R. D. Johnson, Zeyad D. Nassar, Max Moldovan, Claire Levrier, Martin C. Sadowski, Mei Yieng Chin, Emma S. Tomlinson Guns, Gerard Tarulli, David J. Lynn, Douglas A. Brooks, Luke A. Selth, Margaret M. Centenera & Lisa M. Butler. (2018) Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion. Scientific Reports 8:1.
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Adileh Ayati, Rezvan Esmaeili, Setareh Moghimi, Tayebeh Oghabi Bakhshaiesh, Zahra Eslami-S, Keivan Majidzadeh-A, Maliheh Safavi, Saeed Emami & Alireza Foroumadi. (2018) Synthesis and biological evaluation of 4-amino-5-cinnamoylthiazoles as chalcone-like anticancer agents. European Journal of Medicinal Chemistry 145, pages 404-412.
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Hassan Aryapour, Maryam Dehdab, Farzin Sohraby & Afshar Bargahi. (2017) Prediction of new chromene-based inhibitors of tubulin using structure-based virtual screening and molecular dynamics simulation methods. Computational Biology and Chemistry 71, pages 89-97.
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Hassan Mirzaei, Mohammad Shokrzadeh, Mona Modanloo, Ali Ziar, Gholam Hossein Riazi & Saeed Emami. (2017) New indole-based chalconoids as tubulin-targeting antiproliferative agents. Bioorganic Chemistry 75, pages 86-98.
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Mahsa Ansari & Saeed Emami. (2016) β-Ionone and its analogs as promising anticancer agents. European Journal of Medicinal Chemistry 123, pages 141-154.
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Debasis Nayak, Manisha Kumari, Sripathi Rajachandar, Sarbani Ashe, Neethi Chandra Thathapudi & Bismita Nayak. (2016) Biofilm Impeding AgNPs Target Skin Carcinoma by Inducing Mitochondrial Membrane Depolarization Mediated through ROS Production. ACS Applied Materials & Interfaces 8:42, pages 28538-28553.
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Hassan Mirzaei & Saeed Emami. (2016) Recent advances of cytotoxic chalconoids targeting tubulin polymerization: Synthesis and biological activity. European Journal of Medicinal Chemistry 121, pages 610-639.
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Neda Amini, Fadzilah Adibah Abdul Majid, Mohsen Marvibaigi, Eko Supriyanto, Saravana Kumar Jaganathan, Wong Tet Soon, Rozita Nasiri & Javad Hamzehalipour. (2016) Cervicare™ induces apoptosis in HeLa and CaSki cells through ROS production and loss of mitochondrial membrane potential. RSC Advances 6:29, pages 24391-24417.
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Shima H. M. E. Ketabforoosh, Asma Kheirollahi, Maliheh Safavi, Nasim Esmati, Sussan K. Ardestani, Saeed Emami, Loghman Firoozpour, Abbas Shafiee & Alireza Foroumadi. (2014) Synthesis and Anti-Cancer Activity Evaluation of New Dimethoxylated Chalcone and Flavanone Analogs. Archiv der Pharmazie 347:11, pages 853-860.
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Samira Rahmani-Nezhad, Maliheh Safavi, Mahboobeh Pordeli, Sussan Kabudanian Ardestani, Leila Khosravani, Yaghoub Pourshojaei, Mohammad Mahdavi, Saeed Emami, Alireza Foroumadi & Abbas Shafiee. (2014) Synthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2H-chromene derivatives as potent anti-breast cancer agents. European Journal of Medicinal Chemistry 86, pages 562-569.
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H. Surya Prakash Rao & A. Veera Bhadra Rao. (2014) Copper‐Catalyzed C(sp 3 )–C(sp 2 ) Cross‐Coupling: Synthesis of 4‐Aryl‐2‐alkyl­amino‐3‐nitro‐4 H ‐chromenes . European Journal of Organic Chemistry 2014:17, pages 3646-3655.
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Chun Wai Mai, Marzieh Yaeghoobi, Noorsaadah Abd-Rahman, Yew Beng Kang & Mallikarjuna Rao Pichika. (2014) Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins. European Journal of Medicinal Chemistry 77, pages 378-387.
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Mohsen Vosooghi, Hoda Yahyavi, Kouros Divsalar, Hashem Shamsa, Asma Kheirollahi, Maliheh Safavi, Sussan Kabudanian Ardestani, Sareh Sadeghi-Neshat, Negar Mohammadhosseini, Najmeh Edraki, Mehdi Khoshneviszadeh, Abbas Shafiee & Alireza Foroumadi. (2013) Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone. DARU Journal of Pharmaceutical Sciences 21:1.
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