Advanced search
Publication Cover
Pharmaceutical Biology Volume 51, 2013 - Issue 3
Submit an article Journal homepage
2,717
Views
27
CrossRef citations to date
0
Altmetric
Research Article

The effect of silymarin (Silybum marianum) on human skin fibroblasts in an in vitro wound healing model

Roya SharifiDepartment of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
Parvin Pasalar
,
Mohammad KamalinejadDepartment of Pharmacognosy, Faculty of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
,
Ahmad Reza Dehpour
,
Seyed Mohammad TavangarDepartment of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
,
Maliheh PaknejadDepartment of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
Mahbobeh Mehrabani NatanziDepartment of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
Mitra NourbakhshDepartment of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
Hamid Reza Ahmadi Ashtiani
,
Minoo AkbariFood and Drug Control Laboratory and Research Center, Ministry of Health and Medical Education, Tehran, Iran
&
Hossein RastegarFood and Drug Control Laboratory and Research Center, Ministry of Health and Medical Education, Tehran, IranCorrespondence[email protected]
 show all
Pages 298-303 | Received 20 May 2012, Accepted 14 Aug 2012, Published online: 08 Nov 2012

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Nermin M. Sheta, Sylvia A. Boshra, Mohamed A. Mamdouh & Khaled M. Abdel-Haleem. (2022) Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl2 in rats. Drug Delivery 29:1, pages 1299-1311.
Read now
Gajanand Sharma, Yukhti Yachha, Kanika Thakur, Akanksha Mahajan, Gurjeet Kaur, Bhupinder Singh, Kaisar Raza & OP Katare. (2021) Co-delivery of isotretinoin and clindamycin by phospholipid-based mixed micellar system confers synergistic effect for treatment of acne vulgaris. Expert Opinion on Drug Delivery 18:9, pages 1291-1308.
Read now

Articles from other publishers (25)

Yugal Kishore Mohanta, Awdhesh Kumar Mishra, Amilia Nongbet, Ishani Chakrabartty, Saurov Mahanta, Bhaskar Sarma, Jibanjyoti Panda & Sujogya Kumar Panda. (2023) Potential use of the Asteraceae family as a cure for diabetes: A review of ethnopharmacology to modern day drug and nutraceuticals developments. Frontiers in Pharmacology 14.
Crossref
Sally Abdelfattah, Abdelkader Ali Metwally & Maha Nasr. (2023) Silymarin chitosan-modified penetration enhancer microvesicles as a promising wound healing tool. Journal of Drug Delivery Science and Technology 84, pages 104430.
Crossref
Ibrahim Mssillou, Meryem Bakour, Meryem Slighoua, Hassan Laaroussi, Hamza Saghrouchni, Fatima Ez-Zahra Amrati, Badiaa Lyoussi & Elhoussine Derwich. (2022) Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review. Journal of Ethnopharmacology 298, pages 115663.
Crossref
Tatiane Roquete Amparo, Anne Cherem Peixoto da Silva, Janaina Brandão Seibert, Débora dos Santos da Silva, Viviane Martins Rebello dos Santos, Paula Melo de Abreu Vieira, Geraldo Célio Brandão, Gustavo Henrique Bianco de Souza & Bianca Aloise Maneira Corrêa Santos. (2022) In vitro and in silico investigation of the photoprotective and antioxidant potential of Protium spruceanum leaves and its main flavonoids. Journal of Photochemistry and Photobiology A: Chemistry 431, pages 114037.
Crossref
Mohammed Ajjoun, Loubna Kharchoufa, Ilyass Alami Merrouni & Mostafa Elachouri. (2022) Moroccan medicinal plants traditionally used for the treatment of skin diseases: From ethnobotany to clinical trials. Journal of Ethnopharmacology 297, pages 115532.
Crossref
Bahar Kartal, Ebru Alimogulları, Pınar Elçi, Tugba Fatsa & Sema Ören. (2022) The effects of quercetin on wound healing in the human umbilical vein endothelial cells. Cell and Tissue Banking.
Crossref
Karan Wadhwa, Rakesh Pahwa, Manish Kumar, Shobhit Kumar, Prabodh Chander Sharma, Govind Singh, Ravinder Verma, Vineet Mittal, Inderbir Singh, Deepak Kaushik & Philippe Jeandet. (2022) Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules 27:16, pages 5327.
Crossref
Zahra Malekpour-Dehkordi, Mitra Nourbakhsh, Minoo Shahidi, Nazanin Sarraf & Roya Sharifi. (2022) Silymarin diminishes oleic acid-induced lipid accumulation in HepG2 cells by modulating the expression of endoplasmic reticulum stress markers. Journal of Herbal Medicine 33, pages 100565.
Crossref
Shalini Ramalingam, Moola Joghee Nanjan Chandrasekar & Moola Joghee Nanjan. (2022) Plant-based Natural Products for Wound Healing: A Critical Review. Current Drug Research Reviews 14:1, pages 37-60.
Crossref
J. Frankova, J. Juranova, D. Biedermann & J. Ulrichova. (2021) Influence of silymarin components on keratinocytes and 3D reconstructed epidermis. Toxicology in Vitro 74, pages 105162.
Crossref
Prapaporn Chaniad, Supinya Tewtrakul, Teeratad Sudsai, Supat Langyanai & Kantarakorn Kaewdana. (2020) Anti-inflammatory, wound healing and antioxidant potential of compounds from Dioscorea bulbifera L. bulbils. PLOS ONE 15:12, pages e0243632.
Crossref
Anahita Pirtaj Hamedani, Mehdi Behfar & Aliasghar Tehrani. (2020) Effect of Oral Administration of Silymarin on Healing Full-thickness Gastric Wound in Rats. Qom Univ Med Sci J 14:8, pages 10-20.
Crossref
Xin Wang, Zhen Zhang & Shuai-Cheng Wu. (2020) Health Benefits of Silybum marianum : Phytochemistry, Pharmacology, and Applications . Journal of Agricultural and Food Chemistry 68:42, pages 11644-11664.
Crossref
Oya Ustuner, Ceren Anlas, Tulay Bakirel, Fulya Ustun-Alkan, Belgi Diren Sigirci, Seyyal Ak, Huseyin Askin Akpulat, Ceylan Donmez & Ufuk Koca-Caliskan. (2019) In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas. Molecules 24:18, pages 3353.
Crossref
HR Ahmadi Ashtiani, H Rastegar, AA Salarian, F Rahmani, Sh Rezazadeh & H Sedghi Zadeh. (2019) Study the Effect of Silymarin and Vitamin C in Skin Aging Induced by UVB Rays on the Mice Skin Redox System. Journal of Medicinal Plants 3:71, pages 130-144.
Crossref
Jitka Viktorova, Milena Stranska-Zachariasova, Marie Fenclova, Libor Vitek, Jana Hajslova, Vladimir Kren & Tomas Ruml. (2019) Complex Evaluation of Antioxidant Capacity of Milk Thistle Dietary Supplements. Antioxidants 8:8, pages 317.
Crossref
S.A. Tabari, S. Carpi, B. Polini, P. Nieri, M.L. Esfahani, A.A. Moghadamnia, H. Ghorbani, M. Ranaei & S. Kazemi. (2019) Topical application of silymarin enhances cutaneous wound healing in rats. South African Journal of Botany 124, pages 494-498.
Crossref
Jana Juráňová, Juliette Aury-Landas, Karim Boumediene, Catherine Baugé, David Biedermann, Jitka Ulrichová & Jana Franková. (2018) Modulation of Skin Inflammatory Response by Active Components of Silymarin. Molecules 24:1, pages 123.
Crossref
Alexsander R. CarvalhoJr.Jr., Roseana M. Diniz, Mariela A. M. Suarez, Cristiane S. S. e S. Figueiredo, Adrielle Zagmignan, Marcos A. G. Grisotto, Elizabeth S. Fernandes & Luís C. N. da Silva. (2018) Use of Some Asteraceae Plants for the Treatment of Wounds: From Ethnopharmacological Studies to Scientific Evidences. Frontiers in Pharmacology 9.
Crossref
Weijing Cai, Lilibeth A. Salvador-Reyes, Wei Zhang, Qi-Yin Chen, Susan Matthew, Ranjala Ratnayake, Soo Jung Seo, Simon Dolles, Daniel J. Gibson, Valerie J. Paul & Hendrik Luesch. (2017) Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. ACS Chemical Biology 13:1, pages 91-99.
Crossref
Fereshteh Ghorat, Mohammad Azizkhani, Shahriar Naji, Ali Ghorbani Ranjbary & Farzad Doostishoar. (2017) Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing. Iranian Red Crescent Medical Journal 19:1.
Crossref
Monika E. Czerwińska, Katarzyna Duszak, Andrzej Parzonko & Anna K. Kiss. (2016) Chemical Composition and UVA-Protecting Activity of Extracts from Ligustrum vulgare and Olea europaea Leaves. Acta Biologica Cracoviensia s. Botanica 58:2, pages 45-55.
Crossref
Yuanjiang Liao, Xiaochuan Zou, Cun Wang & Xin Zhao. (2016) Insect tea extract attenuates CCl4-induced hepatic damage through its antioxidant capacities in ICR mice. Food Science and Biotechnology 25:2, pages 581-587.
Crossref
Ingrid M. Balsa & William T.N. Culp. (2015) Wound Care. Veterinary Clinics of North America: Small Animal Practice 45:5, pages 1049-1065.
Crossref
Reem T. Atawia, Hala H. Mosli, Mariane G. Tadros, Amani E. Khalifa, Hisham A. Mosli & Ashraf B. Abdel-Naim. (2014) Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB. Naunyn-Schmiedeberg's Archives of Pharmacology 387:12, pages 1131-1140.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.