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Pharmaceutical Biology Volume 51, 2013 - Issue 4
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Research Article

The G-quadruplex ligand, SYUIQ-FM05, targets proto-oncogene c-kit transcription and induces apoptosis in K562 cells

Fei-Hai ShenCenter of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
,
Jing JinCenter of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
,
Jia LiCenter of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
,
Yan WangCenter of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
,
Shao-Hua ZhuCenter of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
,
Yu-Jing LuInstitute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
,
Tian-Miao OuInstitute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR ChinaCorrespondence[email protected] [email protected]
,
Zhi-Shu HuangInstitute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
,
Min HuangInstitute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
&
Zhi-Ying HuangCenter of Preclinical Screening and Evaluation on New Drug, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, PR China
 show all
Pages 447-454 | Received 08 Dec 2011, Accepted 03 Oct 2012, Published online: 30 Jan 2013

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Sebastian Müller & Raphaël Rodriguez. (2014) G-quadruplex interacting small molecules and drugs: from bench toward bedside. Expert Review of Clinical Pharmacology 7:5, pages 663-679.
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Aleyamma Alexander, Archana Sumohan Pillai, Bose Allben Akash, Nallamuthu Ananthi, Haridas Pal, Israel V.M.V. Enoch & Mhejabeen Sayed. (2023) Supramolecular association of a diguanidine derivative with a porphyrin-cyclodextrin conjugate and its binding to G-Quadruplex DNA. Journal of Molecular Structure 1280, pages 135026.
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Vijay K. Nuthakki, Ramesh Mudududdla & Sandip B. Bharate. (2022) Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids. European Journal of Medicinal Chemistry 227, pages 113938.
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Nils Kosiol, Stefan Juranek, Peter Brossart, Annkristin Heine & Katrin Paeschke. (2021) G-quadruplexes: a promising target for cancer therapy. Molecular Cancer 20:1.
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Saikat Pal & Sandip Paul. (2021) An in silico investigation of the binding modes and pathway of APTO-253 on c-KIT G-quadruplex DNA . Physical Chemistry Chemical Physics 23:5, pages 3361-3376.
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Steven D. Shnyder & Colin W. Wright. 2021. Progress in the Chemistry of Organic Natural Products 115. Progress in the Chemistry of Organic Natural Products 115 177 203 .
Eleonora Zorzan, Ramy Elgendy, Mery Giantin, Mauro Dacasto & Claudia Sissi. (2018) Whole-Transcriptome Profiling of Canine and Human in Vitro Models Exposed to a G-Quadruplex Binding Small Molecule. Scientific Reports 8:1.
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Ushasri Chilakamarthi, Devulapally Koteshwar, Sudhakar Jinka, Narra Vamsi Krishna, Kathyayani Sridharan, Narayana Nagesh & Lingamallu Giribabu. (2018) Novel Amphiphilic G-Quadruplex Binding Synthetic Derivative of TMPyP4 and Its Effect on Cancer Cell Proliferation and Apoptosis Induction. Biochemistry 57:46, pages 6514-6527.
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Agata Głuszyńska, Bernard Juskowiak, Martyna Kuta-Siejkowska, Marcin Hoffmann & Shozeb Haider. (2018) Carbazole Derivatives’ Binding to c-KIT G-Quadruplex DNA. Molecules 23:5, pages 1134.
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Pallabi Sengupta, Samit Chattopadhyay & Subhrangsu Chatterjee. (2017) G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment. Drug Discovery Today 22:8, pages 1165-1186.
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Fedor Kouzine, Damian Wojtowicz, Laura Baranello, Arito Yamane, Steevenson Nelson, Wolfgang Resch, Kyong-Rim Kieffer-Kwon, Craig J. Benham, Rafael Casellas, Teresa M. Przytycka & David Levens. (2017) Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome. Cell Systems 4:3, pages 344-356.e7.
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A. Paulo, C.C. Castillo & S. Neidle. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 308 340 .
Eleonora Zorzan, Silvia Da Ros, Caterina Musetti, Lara Zorro Shahidian, Nuno Filipe Ramos Coelho, Federico Bonsembiante, Sébastien Létard, Maria Elena Gelain, Manlio Palumbo, Patrice Dubreuil, Mery Giantin, Claudia Sissi & Mauro Dacasto. (2016) Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models . Oncotarget 7:16, pages 21658-21675.
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Barira Islam, Petr Stadlbauer, Miroslav Krepl, Jaroslav Koca, Stephen Neidle, Shozeb Haider & Jiri Sponer. (2015) Extended molecular dynamics of a c-kit promoter quadruplex . Nucleic Acids Research 43:18, pages 8673-8693.
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Yue Wu, Li-Peng Zan, Xiao-Dong Wang, Yu-Jing Lu, Tian-Miao Ou, Jing Lin, Zhi-Shu Huang & Lian-Quan Gu. (2014) Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:9, pages 2970-2977.
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