Advanced search
Publication Cover
Pharmaceutical Biology Volume 51, 2013 - Issue 6
Submit an article Journal homepage
1,040
Views
19
CrossRef citations to date
0
Altmetric
Research Article

No evidence of hypoglycemia or hypotension in older adults during 6 months of flax lignan supplementation in a randomized controlled trial: A safety evaluation

Jennifer BillinskyCollege of Pharmacy & Nutrition, University of Saskatchewan SaskatoonCanada
,
Riley A. GlewCollege of Pharmacy & Nutrition, University of Saskatchewan SaskatoonCanada
,
Stephen M. CornishDepartment of Kinesiology & Physical Education, University of Lethbridge LethbridgeCanada
,
Susan J. WhitingCollege of Pharmacy & Nutrition, University of Saskatchewan SaskatoonCanadaCorrespondence[email protected]
,
Lilian U. ThorpeCollege of Medicine, University of Saskatchewan SaskatoonCanada
,
Jane AlcornCollege of Pharmacy & Nutrition, University of Saskatchewan SaskatoonCanada
,
Lisa Paus-JenssenCollege of Medicine, University of Saskatchewan SaskatoonCanada
,
Thomas HadjistavropoulosDepartment of Psychology and Centre on Aging and Health, University of Regina ReginaCanada
&
Philip D. ChilibeckCollege of Kinesiology, University of Saskatchewan SaskatoonCanada
 show all
Pages 778-782 | Received 09 Aug 2012, Accepted 04 Jan 2013, Published online: 11 Apr 2013

Citations (19)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Abdul Mueed, Sahar Shibli, Muhammad Jahangir, Saqib Jabbar & Zeyuan Deng. (2023) A comprehensive review of flaxseed (Linum usitatissimum L.): health-affecting compounds, mechanism of toxicity, detoxification, anticancer and potential risk. Critical Reviews in Food Science and Nutrition 63:32, pages 11081-11104.
Read now
Timothy J. Tse, Yajia Guo, Youn Young Shim, Sarah K. Purdy, Ji Hye Kim, Jae Youl Cho, Jane Alcorn & Martin J. T. Reaney. (2023) Availability of bioactive flax lignan from foods and supplements. Critical Reviews in Food Science and Nutrition 63:29, pages 9843-9858.
Read now
Yunyun Di, Franklyn De Silva, Edward S. Krol & Jane Alcorn. (2018) Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3. Nutrition and Cancer 70:2, pages 306-315.
Read now

Articles from other publishers (16)

Abdul Mueed, Zeyuan Deng, Sameh A. Korma, Sahar Shibli & Muhammad Jahangir. (2023) Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives. Food & Function 14:5, pages 2286-2303.
Crossref
Trias Mahmudiono, Saade Abdalkareem Jasim, Yasir Salam Karim, Dmitry Olegovich Bokov, Walid Kamal Abdelbasset, Kholmurod S. Akhmedov, Ghulam Yasin, Lakshmi Thangavelu, Yasser Fakri Mustafa, Shehla Shoukat, Mazin A.A. Najm & Mohammad Amraei. (2022) The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized clinical trials. Phytotherapy Research 36:10, pages 3766-3773.
Crossref
Yajia Guo, Xiaolei Yang, Timothy J. Tse, Sarah K. Purdy, Rana Mustafa, Jianheng Shen, Jane Alcorn & Martin J. T. Reaney. (2021) Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat. Journal of Natural Products 84:11, pages 2845-2850.
Crossref
Salimeh Hajiahmadi, Maryam khosravi, Elham Hosseinzadeh & Mahdieh Hosseinzadeh. (2021) Flaxseed and its products improve glycemic control: A systematic review and meta-analysis. Obesity Medicine 22, pages 100311.
Crossref
Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 1101 1121 .
S. Franklyn De Silva & Jane Alcorn. (2019) Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets. Pharmaceuticals 12:2, pages 68.
Crossref
Mihir Parikh, Thomas Netticadan & Grant N. Pierce. (2018) Flaxseed: its bioactive components and their cardiovascular benefits. American Journal of Physiology-Heart and Circulatory Physiology 314:2, pages H146-H159.
Crossref
Mohsen Mohammadi-Sartang, Zahra Sohrabi, Reza Barati-Boldaji, Hamidreza Raeisi-Dehkordi & Zohreh Mazloom. (2018) Flaxseed supplementation on glucose control and insulin sensitivity: a systematic review and meta-analysis of 25 randomized, placebo-controlled trials. Nutrition Reviews 76:2, pages 125-139.
Crossref
Yunyun Di, Shaoping Ji, Philipp Wolf, Ed S. Krol & Jane Alcorn. (2017) Enterolactone glucuronide and β-glucuronidase in antibody directed enzyme prodrug therapy for targeted prostate cancer cell treatment. AAPS PharmSciTech 18:6, pages 2336-2345.
Crossref
Giuseppe Grosso, Urszula Stepaniak, Agnieszka Micek, Magdalena Kozela, Denes Stefler, Martin Bobak & Andrzej Pajak. (2017) Dietary polyphenol intake and risk of type 2 diabetes in the Polish arm of the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study. British Journal of Nutrition 118:1, pages 60-68.
Crossref
Jane Alcorn, Susan Whiting, Navita Viveky, Yunyun Di, Kerry Mansell, Sharyle Fowler, Lilian Thorpe, Ahmed Almousa, Pui Chi Cheng, Jennifer Jones, Jennifer Billinsky & Thomas Hadjistavropoulos. (2017) Protocol for a 24-Week Randomized Controlled Study of Once-Daily Oral Dose of Flax Lignan to Healthy Older Adults. JMIR Research Protocols 6:2, pages e14.
Crossref
Mohammad Talaei, Bee L. Lee, Choon N. Ong, Rob M. van Dam, Jian M. Yuan, Woon P. Koh & An Pan. (2016) Urine phyto-oestrogen metabolites are not significantly associated with risk of type 2 diabetes: the Singapore Chinese health study. British Journal of Nutrition 115:9, pages 1607-1615.
Crossref
Andrea L. Edel, Michel Aliani & Grant N. Pierce. (2015) Stability of bioactives in flaxseed and flaxseed-fortified foods. Food Research International 77, pages 140-155.
Crossref
Saman Khalesi, Christopher Irwin & Matt Schubert. (2015) Flaxseed Consumption May Reduce Blood Pressure: A Systematic Review and Meta-Analysis of Controlled Trials. The Journal of Nutrition 145:4, pages 758-765.
Crossref
Jatinder Kaur Mukker, Ravi Shankar Prasad Singh, Alister D. Muir, Ed S. Krol & Jane Alcorn. (2015) Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats. British Journal of Nutrition 113:5, pages 749-757.
Crossref
Stephanie P. B. Caligiuri, Andrea L. Edel, Michel Aliani & Grant N. Pierce. (2014) Flaxseed for Hypertension: Implications for Blood Pressure Regulation. Current Hypertension Reports 16:12.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.