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Pharmaceutical Biology Volume 51, 2013 - Issue 7
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Original Article

Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6 kinase-1 inhibition in high-fat–high-fructose diet-fed mice

Elumalai ArunkumarDepartment of Biochemistry and Biotechnology, Annamalai University Tamil NaduIndia
,
Dhanapalan KarthikDepartment of Biochemistry and Biotechnology, Annamalai University Tamil NaduIndia
&
Carani Venkatraman AnuradhaDepartment of Biochemistry and Biotechnology, Annamalai University Tamil NaduIndiaCorrespondence[email protected]
Pages 815-824 | Received 09 Nov 2012, Accepted 09 Jan 2013, Published online: 29 Apr 2013

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Min Zhou, William H. Konigsberg, Canhua Hao, Yinbo Pan, Jie Sun & Xiaojing Wang. (2023) Bioactivity and mechanisms of flavonoids in decreasing insulin resistance. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Chaheyla R St Aubin, Amy L Fisher, Jose A Hernandez, Tom L Broderick & Layla Al-Nakkash. (2022) Mitigation of MAFLD in High Fat-High Sucrose-Fructose Fed Mice by a Combination of Genistein Consumption and Exercise Training. Diabetes, Metabolic Syndrome and Obesity 15, pages 2157-2172.
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J. Li, Y. Liu, T. Wang, L. Zhao & W. Feng. (2016) Does genistein lower plasma lipids and homocysteine levels in postmenopausal women? A meta-analysis. Climacteric 19:5, pages 440-447.
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Articles from other publishers (21)

Guanjie Liu, Liu Yang, Yifei Tang, Jiacheng Lin, Fang Wang, Jie Shen, Bin Chang & Xiaoni Kong. (2024) Study on the action mechanism of the Polygonum perfoliatum L. on non-alcoholic fatty liver disease, based on network pharmacology and experimental validation. Journal of Ethnopharmacology 319, pages 117330.
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Elzbieta Izbicka & Robert T. Streeper. (2023) Mitigation of Insulin Resistance by Natural Products from a New Class of Molecules, Membrane-Active Immunomodulators. Pharmaceuticals 16:7, pages 913.
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Meng Li, Mengqi Qian, Qian Jiang, Bie Tan, Yulong Yin & Xinyan Han. (2023) Evidence of Flavonoids on Disease Prevention. Antioxidants 12:2, pages 527.
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Dongyeop Jang, Hayeong Jeong, Chang-Eop Kim & Jungtae Leem. (2021) A System-Level Mechanism of Anmyungambi Decoction for Obesity: A Network Pharmacological Approach. Biomolecules 11:12, pages 1881.
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María Ángeles Martín & Sonia Ramos. (2021) Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity. Cells 10:6, pages 1474.
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Zhihao Jiang, Zhongmiao Yang, Huihui Zhang, Yao Yao & Haitian Ma. (2021) Genistein activated adenosine 5′-monophosphate-activated protein kinase–sirtuin1/peroxisome proliferator-activated receptor γ coactivator-1α pathway potentially through adiponectin and estrogen receptor β signaling to suppress fat deposition in broiler chickens. Poultry Science 100:1, pages 246-255.
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Fahimeh Zamani-Garmsiri, Seyyed Mohammad Reza Hashemnia, Maryam Shabani, Molood Bagherieh, Solaleh Emamgholipour & Reza Meshkani. (2021) Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice. The Journal of Nutritional Biochemistry 87, pages 108505.
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Viviana Sandoval, Hèctor Sanz-Lamora, Giselle Arias, Pedro F. Marrero, Diego Haro & Joana Relat. (2020) Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral. Nutrients 12:8, pages 2393.
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Linpei Wang, Anquan Li, Yinhao Liu, Shiyang Zhan, Lei Zhong, Youqin Du, Dongyao Xu, Wei Wang & Weifeng Huang. (2020) Genistein protects against acetaminophen-induced liver toxicity through augmentation of SIRT1 with induction of Nrf2 signalling. Biochemical and Biophysical Research Communications 527:1, pages 90-97.
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Darya Ghadimi, Mina Hemmati, Negar Karimi & Tooka Khadive. (2020) Soy Isoflavone Genistein Is a Potential Agent for Metabolic Syndrome Treatment: A Narrative Review. Journal of Advances in Medical and Biomedical Research 28:127, pages 64-75.
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Oeuk Jeong & Hyun-Sook Kim. (2019) Dietary chokeberry and dried jujube fruit attenuates high-fat and high-fructose diet-induced dyslipidemia and insulin resistance via activation of the IRS-1/PI3K/Akt pathway in C57BL/6 J mice. Nutrition & Metabolism 16:1.
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Xin Xin, Cheng Chen, Yi-Yang Hu & Qin Feng. (2019) Protective effect of genistein on nonalcoholic fatty liver disease (NAFLD). Biomedicine & Pharmacotherapy 117, pages 109047.
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Benedetta Russo, Fabiana Picconi, Ilaria Malandrucco & Simona Frontoni. (2019) Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials. International Journal of Molecular Sciences 20:9, pages 2061.
Crossref
Carolyn Marcelo, Melissa Warwick, Catherine Marcelo, Manpreet Malik & Rehan Qayyum. (2018) The relationship between urinary genistein levels and serum alanine aminotransferase levels in adults in the USA: National Health and Nutrition Examination Survey 1999–2010. European Journal of Gastroenterology & Hepatology 30:8, pages 904-909.
Crossref
You Jin Kim, Hye Jin Kim, Hyang Mok Ok, Hye Yun Jeong, Won Jun Lee, Connie Weaver & Oran Kwon. (2018) Effect and interactions of Pueraria-Rehmannia and aerobic exercise on metabolic inflexibility and insulin resistance in ovariectomized rats fed with a high-fat diet. Journal of Functional Foods 45, pages 146-154.
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Hossein Rafiei, Kosar Omidian & Brian Bandy. (2018) Protection by different classes of dietary polyphenols against palmitic acid-induced steatosis, nitro-oxidative stress and endoplasmic reticulum stress in HepG2 hepatocytes. Journal of Functional Foods 44, pages 173-182.
Crossref
Barilin Dkhar, Kitboklang Khongsti, Daiahun Thabah, Donkupar Syiem, Kapaettu Satyamoorthy & Bidyadhar Das. (2017) Genistein represses PEPCK‐C expression in an insulin‐independent manner in HepG2 cells and in alloxan‐induced diabetic mice. Journal of Cellular Biochemistry 119:2, pages 1953-1970.
Crossref
Qian Chen, Tingting Wang, Jian Li, Sijian Wang, Feng Qiu, Haiyang Yu, Yi Zhang & Tao Wang. (2017) Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). Nutrients 9:2, pages 96.
Crossref
Jose Serrano, Anna Cassanye, Meritxell Martín-Gari, Ana Granado-Serrano & Manuel Portero-Otín. (2016) Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility. Diseases 4:1, pages 14.
Crossref
Robert Domitrović & Iva Potočnjak. (2015) A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives. Archives of Toxicology 90:1, pages 39-79.
Crossref
Min-Hsiung Pan, Ching-Shu Lai, Mei-Ling Tsai & Chi-Tang Ho. (2014) Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds. Molecular Nutrition & Food Research 58:1, pages 147-171.
Crossref

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