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Review Article

Role of saffron and its constituents on cancer chemoprevention

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Pages 920-924 | Received 30 Aug 2012, Accepted 24 Jan 2013, Published online: 09 Apr 2013

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Abdul Rahaman, Ankita Kumari, Muhammad Adil Farooq, Xin-An Zeng, Sadia Hassan, Ibrahim Khalifa, Rana Muhammad Aadil, Muhammad Farhan Jahangir Chughtai, Adnan Khaliq, Nabeel Ahmad & Mohd Anas Wajid. (2023) Novel Extraction Techniques: An Effective Way to Retrieve the Bioactive Compounds from Saffron (Crocus Sativus). Food Reviews International 39:5, pages 2655-2683.
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G. K. Broadhead, A. Chang, J. Grigg & P. McCluskey. (2016) Efficacy and Safety of Saffron Supplementation: Current Clinical Findings. Critical Reviews in Food Science and Nutrition 56:16, pages 2767-2776.
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Javid A Parray, Azra N Kamili, Rehana Hamid, Zafar A Reshi & Raies A Qadri. (2015) Antibacterial and antioxidant activity of methanol extracts of Crocus sativus L. c.v. Kashmirianus. Frontiers in Life Science 8:1, pages 40-46.
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Shahrbanou Ashrafian, Mahshid Zarrineh, Pia Jensen, Arkadiusz Nawrocki, Hassan Rezadoost, Alireza Madjid Ansari, Leila Farahmand, Alireza Ghassempour & Martin R. Larsen. (2022) Quantitative Phosphoproteomics and Acetylomics of Safranal Anticancer Effects in Triple-Negative Breast Cancer Cells. Journal of Proteome Research 21:11, pages 2566-2585.
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Alberto José López-Jiménez, Lucía Morote, Enrique Niza, María Mondéjar, Ángela Rubio-Moraga, Gianfranco Diretto, Oussama Ahrazem & Lourdes Gómez-Gómez. (2022) Subfunctionalization of D27 Isomerase Genes in Saffron. International Journal of Molecular Sciences 23:18, pages 10543.
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Tahir ul Gani Mir, Atif Khurshid Wani, Jaskaran Singh & Saurabh Shukla. (2022) Therapeutic application and toxicity associated with Crocus sativus (saffron) and its phytochemicals. Pharmacological Research - Modern Chinese Medicine 4, pages 100136.
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Raheleh Shakeri, Bahram Savari, Mahsa N. Sheikholeslami, Tayebeh Radjabian, Jalal Khorshidi & Maliheh Safavi. (2022) Untargeted Metabolomics Analysis of Crocus cancellatus subsp. damascenus (Herb.) B. Mathew Stigmas and Their Anticarcinogenic Effect on Breast Cancer Cells. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-15.
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Neda Roshanravan & Samad Ghaffari. (2021) The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials . Phytotherapy Research 36:1, pages 98-111.
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Zahid Yaqoob Bhat, Tabasum Mohiuddin, Amit Kumar, Alberto José López-Jiménez & Nasheeman Ashraf. (2021) Crocus transcription factors CstMYB1 and CstMYB1R2 modulate apocarotenoid metabolism by regulating carotenogenic genes. Plant Molecular Biology 107:1-2, pages 49-62.
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Azza A. Attia, Heba S. Ramdan, Rasha A. Al-Eisa, Bassant O. A. Adle Fadle & Nahla S. El-Shenawy. (2021) Effect of Saffron Extract on the Hepatotoxicity Induced by Copper Nanoparticles in Male Mice. Molecules 26:10, pages 3045.
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Çiğdem Muştu. (2021) A Research on Properties, History of Saffron (Crocus sativus L.) and its Use in Foods. Food and Health 7:4, pages 300-310.
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Hifzur R. Siddique, Homa Fatma & Mohammad Afsar Khan. 2020. Saffron. Saffron 233 244 .
Elias Begas, Maria Bounitsi, Thomas Kilindris, Evangelos Kouvaras, Konstantinos Makaritsis, Demetrios Kouretas & Eftihia K. Asprodini. (2019) Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food and Chemical Toxicology 130, pages 32-43.
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Olga Mykhailenko, Volodymyr Kovalyov, Olga Goryacha, Liudas Ivanauskas & Victoriya Georgiyants. (2019) Biologically active compounds and pharmacological activities of species of the genus Crocus: A review. Phytochemistry 162, pages 56-89.
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Di Zhou, Gang Chen, Jian Wang & Ning Li. (2017) Natural Cancer Chemopreventive Reagents from Food and Herbals. Current Pharmacology Reports 3:3, pages 138-149.
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Jun-ling Li, Shi-li Wang, Jin-xiang Han, Hai Xu, Xiao-bin Xu & Jun-ying Xue. (2017) Inhibition of Yuyihe Powder on Tumor Growth in Mice Models of Sarcoma 180. Chinese Herbal Medicines 9:2, pages 183-187.
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Shinya Okubo, Takuhiro Uto, Aya Goto, Hiroyuki Tanaka, Tsuyoshi Nishioku, Katsushi Yamada & Yukihiro Shoyama. (2017) Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure–Activity Relationships. The American Journal of Chinese Medicine 45:07, pages 1497-1511.
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Zahoor Ahmed Wani, Dania Nazir Mirza, Palak Arora & Syed Riyaz-Ul-Hassan. (2016) Molecular phylogeny, diversity, community structure, and plant growth promoting properties of fungal endophytes associated with the corms of saffron plant: An insight into the microbiome of Crocus sativus Linn.. Fungal Biology 120:12, pages 1509-1524.
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Parya Hashemi & F. Bedia Erim. (2016) Analysis of Vitamin B2 in Saffron Stigmas (Crocus sativus L) by Capillary Electrophoresis Coupled with Laser-Induced Fluorescence Detector. Food Analytical Methods 9:8, pages 2395-2399.
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Shoib Ahmad Baba, Tabasum Mohiuddin, Swaraj Basu, Mohit Kumar Swarnkar, Aubid Hussain Malik, Zahoor Ahmed Wani, Nazia Abbas, Anil Kumar Singh & Nasheeman Ashraf. (2015) Comprehensive transcriptome analysis of Crocus sativus for discovery and expression of genes involved in apocarotenoid biosynthesis. BMC Genomics 16:1.
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Shoib Ahmad Baba, Aubid Hussain Malik, Zahoor Ahmed Wani, Tabasum Mohiuddin, Zeeshan Shah, Nazia Abbas & Nasheeman Ashraf. (2015) Phytochemical analysis and antioxidant activity of different tissue types of Crocus sativus and oxidative stress alleviating potential of saffron extract in plants, bacteria, and yeast. South African Journal of Botany 99, pages 80-87.
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Nasheeman Ashraf, Deepti Jain & Ram A Vishwakarma. (2015) Identification, cloning and characterization of an ultrapetala transcription factor CsULT1 from Crocus: a novel regulator of apocarotenoid biosynthesis. BMC Plant Biology 15:1, pages 25.
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Angela Rubio Moraga, Oussama Ahrazem, José Luis Rambla, Antonio Granell & Lourdes Gómez Gómez. (2013) Crocins with High Levels of Sugar Conjugation Contribute to the Yellow Colours of Early-Spring Flowering Crocus Tepals. PLoS ONE 8:9, pages e71946.
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