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Research Article

Evaluation of anti-inflammatory effect of Withania somnifera root on collagen-induced arthritis in rats

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Pages 308-320 | Received 22 Feb 2013, Accepted 13 Aug 2013, Published online: 05 Nov 2013

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Muskan Gupta & Gurcharan Kaur. (2018) Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation. NeuroMolecular Medicine 20:3, pages 343-362.
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Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Equar Taka & Karam F.A. Soliman. (2017) Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells. Journal of Neuroimmunology 302, pages 10-19.
Crossref
Muzamil Ahmad & Nawab J. Dar. 2017. Sustained Energy for Enhanced Human Functions and Activity. Sustained Energy for Enhanced Human Functions and Activity 137 154 .
Rajat Sandhir & Abhilasha Sood. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 373 387 .
Elizabeth A. Mazzio, Nan Li, David Bauer, Patricia Mendonca, Equar Taka, Mohammed Darb, Leeshawn Thomas, Henry Williams & Karam F. A. Soliman. (2016) Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis. BMC Complementary and Alternative Medicine 16:1.
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Amitabha Dey, Shyam Sunder Chatterjee & Vikas Kumar. (2016) Analgesic activity of a Withania somnifera extract in stressed mice. Oriental Pharmacy and Experimental Medicine 16:4, pages 295-302.
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Shailendra Bhatt, Priyanka Shukla, Jibril Raval & Sunita Goswami. (2016) Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats. Basic & Clinical Pharmacology & Toxicology 119:1, pages 10-18.
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Shan Huang, Hai Feng Liu, Xianghua Quan, Yan Jin, Guangshan Xuan, Ren-Bo An, Tsering Dikye & Bin Li. (2016) Rhamnella gilgitica Attenuates Inflammatory Responses in LPS-Induced Murine Macrophages and Complete Freund’s Adjuvant-Induced Arthritis Rats . The American Journal of Chinese Medicine 44:07, pages 1379-1392.
Crossref
Peter T. White, Chitra Subramanian, Hashim F. Motiwala & Mark S. Cohen. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 329 373 .
Nawab John Dar, Abid Hamid & Muzamil Ahmad. (2015) Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cellular and Molecular Life Sciences 72:23, pages 4445-4460.
Crossref
Jonathan Gorelick, Rivka Rosenberg, Avinoam Smotrich, Lumír Hanuš & Nirit Bernstein. (2015) Hypoglycemic activity of withanolides and elicitated Withania somnifera. Phytochemistry 116, pages 283-289.
Crossref
Vikas Kumar, Amitabha Dey, Mallinath B. Hadimani, Tatjana Marcovic & Mila Emerald. (2015) Chemistry and pharmacology of withania somnifera: An update. TANG [HUMANITAS MEDICINE] 5:1, pages 1.1-1.13.
Crossref
Vikram Khedgikar, Naseer Ahmad, Priyanka Kushwaha, Jyoti Gautam, Geet K. Nagar, Divya Singh, Prabodh K. Trivedi, Prabhat R. Mishra, Neelam S. Sangwan & Ritu Trivedi. (2015) Preventive effects of withaferin A isolated from the leaves of an Indian medicinal plant Withania somnifera (L.): Comparisons with 17-β-estradiol and alendronate. Nutrition 31:1, pages 205-213.
Crossref
Sukhbir Kaur, Kalpana Chauhan & Heena Sachdeva. (2014) Protection against experimental visceral leishmaniasis by immunostimulation with herbal drugs derived from Withania somnifera and Asparagus racemosus. Journal of Medical Microbiology 63:10, pages 1328-1338.
Crossref
Shaily Goyal, Jaya Arora & Kishan G. Ramawat. 2014. Biotechnology and Biodiversity. Biotechnology and Biodiversity 203 245 .

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