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Pharmaceutical Biology Volume 53, 2015 - Issue 12
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Original Article

Hepatoprotective effect of Commiphora myrrha against d-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes

Ajaz AhmadDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia,
,
Mohammad RaishDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia,
,
Majid A. GanaieDepartment of Pharmacology, College of Pharmacy, Salman Bin-Abdulaziz University, AlKharj, Saudi Arabia,
,
Syed Rizwan AhmadResearch Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia,
,
Kazi MohsinDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia,
,
Fahad I. Al-JenoobiDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia,
,
Abdullah M. Al-MohizeaDepartment of Pharmacology, College of Pharmacy, Salman Bin-Abdulaziz University, AlKharj, Saudi Arabia,
&
Khalid M. AlkharfyDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, ;Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, Saudi Arabia, and ;Biomarkers Research Program, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence[email protected]
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Pages 1759-1767 | Received 04 Jun 2014, Accepted 02 Jan 2015, Published online: 05 May 2015

Citations (23)

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Shuxian Zhao, Yan Liu & Zenghui Pu. (2019) Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro. Drug Design, Development and Therapy 13, pages 2887-2897.
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Articles from other publishers (22)

Amira M. Elmoslemany, Mohamed Elzallat, Mai Hussein Abd-Elfatah, Dina Mostafa Mohammed & Eman E.Abd Elhady. (2024) Possible therapeutic effect of frankincense (Gum olibanum) and myrrh (Commiphora myrrha) resins extracts on DEN/CCL4 induced hepatocellular carcinoma in rats. Phytomedicine Plus 4:1, pages 100517.
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Nancy S. Younis. (2023) Myrrh Essential Oil Mitigates Renal Ischemia/Reperfusion-Induced Injury. Current Issues in Molecular Biology 45:2, pages 1183-1196.
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Hend Mohamed Anter, Reham Mokhtar Aman, Ahmed Abdelaziz Shaaban, Irhan Ibrahim Abu Hashim & Mahasen Mohamed Meshali. (2022) Propitious maneuvering for delivery of the phytopharmaceutical “apocynin” to induced fulminant hepatitis in BALB/c mice: In vitro and in vivo assessments. International Journal of Pharmaceutics 626, pages 122165.
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Cuiyun Zou, Xinyue Hu, Yingxin Wu, Lijuan Zhao, Rishen Liang, Dongyi Cao, Meng Zhou & Li Lin. (2022) Protective role of Saikosaponin d in d-galactosamine and lipopolysaccharide-induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). Aquaculture 548, pages 737601.
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Ali S. Alqahtani, Rashed N. Herqash, Faleh Alqahtani, Syed Rizwan Ahamad, Fahd A. Nasr & Omar M. Noman. (2021) GC-MS Method for Quantification and Pharmacokinetic Study of Four Volatile Compounds in Rat Plasma after Oral Administration of Commiphora myrrh (Nees) Engl. Resin and In Vitro Cytotoxic Evaluation. Separations 8:12, pages 239.
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Mohammadmehdi Hassanzadeh-Taheri, Mojtaba Salimi, Khadijeh Vazifeshenas-Darmiyan, Mahtab Mohammadifard & Mehran Hosseini. (2021) Investigating the effect of ethanolic extract of Commiphora myrrha (Nees) Engl. gum-resin against hepatorenal injury in diabetic rats. Journal of Diabetes & Metabolic Disorders 20:2, pages 1573-1581.
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Md Anzar Alam, Mohd Aleemuddin Quamri, Umme Ayman, Ghulamuddin Sofi & Bangalore Nagaraj Renuka. (2021) Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine . Journal of Complementary and Integrative Medicine 18:3, pages 469-476.
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Chia-Yu HuangMei-Yao WuHsiang-Chi WangYuan-Ching LiaoSio-Ian TouHung-Rong Yen. (2021) Chinese Herbal Medicine Decreases Incidence of Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease in Taiwan: A Propensity Score-Matched Cohort Study. The Journal of Alternative and Complementary Medicine 27:7, pages 596-605.
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Nancy S. Younis & Maged E. Mohamed. (2021) Protective effects of myrrh essential oil on isoproterenol-induced myocardial infarction in rats through antioxidant, anti-inflammatory, Nrf2/HO-1 and apoptotic pathways. Journal of Ethnopharmacology 270, pages 113793.
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Sana Fatima, Nafis Haider, Md Anzar Alam, Mohd Abdul Gani, Rafeeque Ahmad & Murtada Taha. (2021) Herbal approach for the management of C0VID-19: an overview. Drug Metabolism and Drug Interactions 36:1, pages 1-8.
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Soodeh Karami, Shiva Shamshiri, Mohammad Abdollahi & Roja Rahimi. (2021) An Evidence-based Review of Medicinal Plants used in Traditional Persian Medicine for Treatment of Osteoarthritis. Current Drug Discovery Technologies 18:2, pages 244-271.
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Md Anzar Alam, Mohd Aleemuddin Quamri, Ghulamuddin Sofi, Umme Ayman, Shabnam Ansari & Mariyam Ahad. (2020) Understanding COVID-19 in the light of epidemic disease described in Unani medicine. Drug Metabolism and Drug Interactions 35:4.
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Sana Fatima, Nafis Haider, Md Anzar Alam, Mohd Abdul Gani, Rafeeque Ahmad & Murtada Taha. (2020) Herbal approach for the management of C0VID-19: an overview. Drug Metabolism and Personalized Therapy 0:0.
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Md Anzar Alam, Mohd Aleemuddin Quamri, Ghulamuddin Sofi, Umme Ayman, Shabnam Ansari & Mariyam Ahad. (2020) Understanding COVID-19 in the light of epidemic disease described in Unani medicine. Drug Metabolism and Personalized Therapy 0:0.
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Hammad Ullah, Ajmal Khan, Najeeb Ur Rehman, Sobia Ahsan Halim, Haroon Khan, Imran Khan, Rene Csuk, Ahmed Al-Rawahi, Saif Al-Hatmi & Ahmed Al-Harrasi. (2020) Lophenol and lathosterol from resin of Commiphora kua possess hepatoprotective effects in vivo. Journal of Ethnopharmacology 252, pages 112558.
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Sahar H. Orabi, Eman SH. Al-Sabbagh, Hanem K. Khalifa, Mostafa Abd El-Gaber Mohamed, Moustafa Elhamouly, Shaban M. Gad-Allah, Mohamed M. Abdel-Daim & Mabrouk A. Abd Eldaim. (2020) Commiphora myrrha Resin Alcoholic Extract Ameliorates High Fat Diet Induced Obesity via Regulation of UCP1 and Adiponectin Proteins Expression in Rats. Nutrients 12:3, pages 803.
Crossref
Zhaojian Zhang, Liang Tian & Kai Jiang. (2019) Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-κB/NLRP3 pathway. International Immunopharmacology 77, pages 105974.
Crossref
Cuiyun Zou, Xiaohong Tan, Huaqun Ye, Zhenzhu Sun, Shu Chen, Qingying Liu, Minglei Xu, Chaoxia Ye & Anli Wang. (2018) The hepatoprotective effects of Radix Bupleuri extracts against D-galactosamine/lipopolysaccharide induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). Fish & Shellfish Immunology 83, pages 8-17.
Crossref
R. S. Maghembe, G. Bakari G.A. Max R.T. Balthazary S.. (2017) Effect of Commiphora swynnertonii resin on liver functions and levels of plasma glucose and lipids in carbon-tetrachloride treated chickens. International Journal of Nutrition and Metabolism 9:7, pages 58-66.
Crossref
Ayman M. Mahmoud, Sultan Alqahtani, Sarah I. Othman, Mousa O. Germoush, Omnia E. Hussein, Gadh Al-Basher, Jong Seong Khim, Maha A. Al-Qaraawi, Hanan M. Al-Harbi, Abdulmannan Fadel & Ahmed A. Allam. (2017) Commiphora molmol Modulates Glutamate-Nitric Oxide-cGMP and Nrf2/ARE/HO-1 Pathways and Attenuates Oxidative Stress and Hematological Alterations in Hyperammonemic Rats . Oxidative Medicine and Cellular Longevity 2017, pages 1-15.
Crossref
Zhenxing He, Xuanfei Li, Hao Chen, Kun He, Yiming Liu, Junhua Gong & Jianping Gong. (2016) Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated cytokine production. Molecular Medicine Reports 14:6, pages 5595-5600.
Crossref
Mohammad Raish, Ajaz Ahmad, Khalid M. Alkharfy, Syed Rizwan Ahamad, Kazi Mohsin, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea & Mushtaq Ahmad Ansari. (2016) Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model. BMC Complementary and Alternative Medicine 16:1.
Crossref

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