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Research Article

Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity

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Pages 1680-1686 | Received 22 Aug 2014, Accepted 10 Nov 2015, Published online: 26 Feb 2016

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Sungwan Ahn, Hwayoung Yun & Young Taek Han. (2018) An Improved C-Deglycosylation of Mangiferin to Norathyriol. Organic Preparations and Procedures International 50:1, pages 91-94.
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Articles from other publishers (20)

Zhongqi Shi, Xueli Ge, Shuna Zheng, Pengjiao Zeng, Zhenguo Su, Xiulian Li & Jiayu Zhang. (2023) Mangiferin reduces uric acid via regulation of amino acid and lipid metabolism. Journal of Functional Foods 108, pages 105716.
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Miriam Martinez-Canton, Victor Galvan-Alvarez, Eduardo Garcia-Gonzalez, Angel Gallego-Selles, Miriam Gelabert-Rebato, Giovanni Garcia-Perez, Alfredo Santana, Laura Lopez-Rios, Tanausu Vega-Morales, Marcos Martin-Rincon & Jose A. L. Calbet. (2023) A Mango Leaf Extract (Zynamite®) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle. Nutrients 15:13, pages 2848.
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Hongyan Zhou, Shuyi Song, Xianming Lan, Yanan Li, Xiaoqing Yuan, Jingyi Yang, Min Li, Ting Cao & Jiayu Zhang. (2023) Comprehensive Profiling of Mangiferin Metabolites In Vivo and In Vitro Based on the “Drug Metabolite Clusters” Analytical Strategy. ACS Omega 8:11, pages 9934-9946.
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Fanying Meng, Fan Zhang, Qiuding Chen, Min Yang, Yaqin Yang, Xue Li, Wen Gu & Jie Yu. (2022) Virtual screening and in vitro experimental verification of LuxS inhibitors from natural products for Lactobacillus reuteri. Biomedicine & Pharmacotherapy 147, pages 112521.
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Uswatun Hasanah, Kasumi Miki, Teruhiko Nitoda & Hiroshi Kanzaki. (2021) Aerobic bioconversion of C -glycoside mangiferin into its aglycone norathyriol by an isolated mouse intestinal bacterium . Bioscience, Biotechnology, and Biochemistry 85:4, pages 989-997.
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Liqian Chen, Zhengmao Luo, Ming Wang, Jingru Cheng, Fei Li, Hanqi Lu, Qiuxing He, Yanting You, Xinghong Zhou, Hiu Yee Kwan, Xiaoshan Zhao & Lin Zhou. (2021) The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review. Frontiers in Pharmacology 11.
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Ilkay E. Orhan & Fatma S.S. Deniz. (2021) Natural Products and Extracts as Xantine Oxidase Inhibitors - A Hope for Gout Disease?. Current Pharmaceutical Design 27:2, pages 143-158.
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Qiurui Li, Hua Lin, Yanfen Niu, Yan Liu, Zhenyu Wang, Liudong Song, Lihui Gao & Ling Li. (2020) Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. European Journal of Pharmacology 888, pages 173490.
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Liangliang Liu, Li Zhang, Licheng Ren & Yixi Xie. (2020) Advances in structures required of polyphenols for xanthine oxidase inhibition. Food Frontiers 1:2, pages 152-167.
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Marcos Martin-Rincon, Miriam Gelabert-Rebato, Victor Galvan-Alvarez, Angel Gallego-Selles, Miriam Martinez-Canton, Laura Lopez-Rios, Julia C. Wiebe, Saul Martin-Rodriguez, Rafael Arteaga-Ortiz, Cecilia Dorado, Sergio Perez-Regalado, Alfredo Santana, David Morales-Alamo & Jose A L Calbet. (2020) Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise. Nutrients 12:3, pages 614.
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Xuechen Li, Zhenxin Yan, Mattias Carlström, Jinying Tian, Xiaolin Zhang, Wenxuan Zhang, Song Wu & Fei Ye. (2020) Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion. Frontiers in Pharmacology 11.
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Miriam Gelabert-Rebato, Marcos Martin-Rincon, Victor Galvan-Alvarez, Angel Gallego-Selles, Miriam Martinez-Canton, Tanausú Vega-Morales, Julia C. Wiebe, Constanza Fernandez-del Castillo, Elizabeth Castilla-Hernandez, Oriana Diaz-Tiberio & Jose A. L. Calbet. (2019) A Single Dose of The Mango Leaf Extract Zynamite® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women. Nutrients 11:11, pages 2592.
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Jing Wang, Wuwen Feng, Fei Tang, Hui Ao & Cheng Peng. (2019) Gut microbial transformation, a potential improving factor in the therapeutic activities of four groups of natural compounds isolated from herbal medicines. Fitoterapia 138, pages 104293.
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Hua Lin, Caixia Tu, Yanfen Niu, Fashuang Li, Lixian Yuan, Na Li, Aiping Xu, Lihui Gao & Ling Li. (2019) Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition. European Journal of Pharmacology 853, pages 371-380.
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Wenjie Xue, Jinlong Tian, Xiang Simon Wang, Jie Xia & Song Wu. (2019) Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives. Bioorganic Chemistry 86, pages 224-234.
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Miriam Gelabert-Rebato, Julia C. Wiebe, Marcos Martin-Rincon, Victor Galvan-Alvarez, David Curtelin, Mario Perez-Valera, Julian Juan Habib, Alberto Pérez-López, Tanausú Vega, David Morales-Alamo & Jose A L Calbet. (2019) Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men. Nutrients 11:2, pages 344.
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Xiaozhen Guo, Mingcang Cheng, Pei Hu, Zhangpeng Shi, Shuoji Chen, Huan Liu, Haoyun Shi, Zhou Xu, Xiaoting Tian & Chenggang Huang. (2018) Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS. Journal of Agricultural and Food Chemistry 66:46, pages 12227-12235.
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Miriam Gelabert-Rebato, Julia C. Wiebe, Marcos Martin-Rincon, Nigel Gericke, Mario Perez-Valera, David Curtelin, Victor Galvan-Alvarez, Laura Lopez-Rios, David Morales-Alamo & Jose A. L. Calbet. (2018) Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans. Frontiers in Physiology 9.
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Hua Yang, Wenwei Bai, Lihui Gao, Jun Jiang, Yingxi Tang, Yanfen Niu, Hua Lin & Ling Li. (2018) Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases. Journal of Pharmacological Sciences 137:2, pages 154-161.
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Xiaodan Wang, Lihui Gao, Hua Lin, Jingling Song, Jinwen Wang, Yumin Yin, Jianghu Zhao, Xiangwei Xu, Zhenkun Li & Ling Li. (2018) Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli. European Journal of Pharmacology 824, pages 170-178.
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