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Research Article

In vitro and in vivo antitumour activities of puerarin 6″-O-xyloside on human lung carcinoma A549 cell line via the induction of the mitochondria-mediated apoptosis pathway

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Pages 1793-1799 | Received 30 Mar 2015, Accepted 01 Dec 2015, Published online: 05 Jan 2016

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Read on this site (3)

Bashir Ahmad, Suliman Khan, Yang Liu, Mengzhou Xue, Ghulam Nabi, Sunjeet Kumar, Mohammed Alshwmi & Abdul Wakeel Qarluq. (2020) Molecular Mechanisms of Anticancer Activities of Puerarin. Cancer Management and Research 12, pages 79-90.
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Yeon Ju Kim, Haribalan Perumalsamy, Verónica Castro-Aceituno, Donghyuk Kim, Josua Markus, Seungah Lee, Sung Kim, Ying Liu & Deok Chun Yang. (2019) Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines. International Journal of Nanomedicine 14, pages 8195-8208.
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Articles from other publishers (15)

Harinder Singh, Priyanka KriplaniSweta Kamboj & Kumar Guarve. (2024) Puerarin: An Anticancer and Anti-Inflammatory Agent. Recent Patents on Anti-Cancer Drug Discovery 19:1, pages 18-36.
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Xindong Chen, Zhiruo Zhou, Zhi Zhang, Chenhao Zhao, Jiayu Li, Jingwen Jiang, Biao Huang & Yuan Qin. (2022) Puerarin inhibits EMT induced by oxaliplatin via targeting carbonic anhydrase XII. Frontiers in Pharmacology 13.
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Yaxi Han, Dong-Uk Yang, Yue Huo, Jianyu Pu, Seung-Jin Lee, Deok-Chun Yang & Se Chan Kang. (2021) In Vitro Evaluation of Anti-Lung Cancer and Anti-COVID-19 Effects using Fermented Black Color Ginseng Extract . Natural Product Communications 16:9, pages 1934578X2110343.
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Xuhong Chang, Minmin Tian, Qiong Zhang, Fangfang Liu, Jinxia Gao, Sheng Li, Han Liu, Xiangbo Hou, Lei Li, Chengyun Li & Yingbiao Sun. (2021) Grape seed proanthocyanidin extract ameliorates cisplatin‐induced testicular apoptosis via PI3K/Akt/mTOR and endoplasmic reticulum stress pathways in rats. Journal of Food Biochemistry 45:8.
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Bhanupriya Kanthaliya, Abhishek Joshi, Supriya Meena & Jaya Arora. 2021. Medicinal Plants. Medicinal Plants 693 719 .
Long Li, Jun‐Dong Liu, Guo‐Dong Gao, Kai Zhang, Yu‐Wei Song & Hong‐Bo Li. (2020) Puerarin 6″‐O‐xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR. Cancer Medicine 9:17, pages 6399-6410.
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Xiaomei Tao, Yefeng Yin, Dongbo Lian, Hongyan Gu, Wen Chen, Lu Yang, Gang Yin, Pengfei Liu, Lili Li, Yuanyuan Wei, Zhengzheng Xie, Fei Liu, Hangshuo Sui, Dan Yan & Weiwei Tao. (2020) Puerarin 6″‐O‐xyloside suppresses growth, self‐renewal and invasion of lung cancer stem‐like cells derived from A549 cells via regulating Akt/c‐Myc signalling. Clinical and Experimental Pharmacology and Physiology 47:7, pages 1311-1319.
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Manikanta Murahari, Vikas Singh, Pramila Chaubey & Vasanti Suvarna. (2020) A Critical Review on Anticancer Mechanisms of Natural Flavonoid Puerarin. Anti-Cancer Agents in Medicinal Chemistry 20:6, pages 678-686.
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Yuefei Zhang, Zhangli Zhou, Lian Zou, Mei Zhang & Ruan Chi. (2019) Investigating the solid-liquid extraction process of puerarin by molecular dynamics simulations. International Journal of Heat and Mass Transfer 143, pages 118584.
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Tianyi Yuan, Huifang Zhang, Di Chen, Yucai Chen, Yang Lyu, Lianhua Fang & Guanhua Du. (2019) Puerarin protects pulmonary arteries from hypoxic injury through the BMPRII and PPARγ signaling pathways in endothelial cells. Pharmacological Reports 71:5, pages 855-861.
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Guomei Ye, Shifeng Kan, Jianfeng Chen & Xin Lu. (2018) Puerarin in inducing apoptosis of bladder cancer cells through inhibiting SIRT1/p53 pathway. Oncology Letters.
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Xiao‑Lan Zhang, Bin‑Bin Wang & Jian‑Shu Mo. (2018) Puerarin 6''‑O‑xyloside possesses significant antitumor activities on colon cancer through inducing apoptosis. Oncology Letters.
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Xu Ma, Lei Yan, Qing Zhu & Fengmin Shao. (2017) Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway. PLOS ONE 12:2, pages e0171612.
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Li-Ling Shen, Chih-Hsin Muo, Shan-Yu Su & Donald E. Morisky. (2017) Use of Chinese Medicine Reduces the Development of Cervical Cancer from Pap Smear-Diagnosed Cervical Dysplasia: A Case-Control Study. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-7.
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Hua Qin, Yan Zhang, Ru Wang, Xiaoyan Du, Liping Li & Haiwei Du. (2016) Puerarin Suppresses Na+-K+-ATPase–Mediated Systemic Inflammation and CD36 Expression, and Alleviates Cardiac Lipotoxicity In Vitro and In Vivo. Journal of Cardiovascular Pharmacology 68:6, pages 465-472.
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