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Pharmaceutical Biology Volume 54, 2016 - Issue 10
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Research Article

Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-κB signalling pathway in human chronic myelogenous leukaemia

Sung-Moo Kim
,
Eun-Jung LeeDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
,
Jong Hyun LeeDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
,
Woong Mo YangDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
,
Dongwoo NamDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
,
Jun-Hee LeeDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
,
Seok-Geun LeeDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
,
Jae-Young UmDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
,
Bum Sang ShimDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea
&
Kwang Seok AhnDepartment of Oriental Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaCorrespondence[email protected]
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Pages 2050-2060 | Received 14 Jul 2015, Accepted 07 Jan 2016, Published online: 25 Feb 2016

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José Villalaín. (2023) Bergamottin: location, aggregation and interaction with the plasma membrane. Journal of Biomolecular Structure and Dynamics 41:21, pages 12026-12037.
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Zhongfang Zhao & Nong Liao. (2021) Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis. OncoTargets and Therapy 14, pages 3769-3781.
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Bushra Aziz, Iffat Aziz, Ahmat Khurshid, Ehsan Raoufi, Fahime Nasr Esfahani, Zahra Jalilian, M. R. Mozafari, Elham Taghavi & Masroor Ikram. (2023) An Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy. Biomedicines 11:1, pages 224.
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Fatemeh Zahedipour, Alexandra E. Butler, Manfredi Rizzo & Amirhossein Sahebkar. (2022) Statins and angiogenesis in non-cardiovascular diseases. Drug Discovery Today 27:10, pages 103320.
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Lixia Fan, Wanqin Liao, Zezhen Chen, Shaojing Li, Anping Yang, Min-Min Chen, Hui Liu & Fang Liu. (2022) In vitro and in vivo anti-lymphoma effects of Ophiorrhiza pumila extract. Aging 14:9, pages 3801-3812.
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Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Habbanakuppe D. Preetham, S. Chandra Nayaka, Vijai K. Gupta, Salundi Basappa, Gautam Sethi & Kanchugarakoppal S. Rangappa. (2022) Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature. Seminars in Cancer Biology 80, pages 157-182.
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Tomasz Piotr Kubrak, Przemysław Kołodziej, Jan Sawicki, Anna Mazur, Katarzyna Koziorowska & David Aebisher. (2022) Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy. Molecules 27:4, pages 1192.
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Saisai Liu, Dan Song & Dongya Yuan. (2021) Bergamottin protects against LPS-induced endotoxic shock by regulating the NF-κB signaling pathway. Immunologic Research 70:1, pages 33-43.
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Wen Jiang, Jin-Wei Hu, Xu-Ran He, Wei-Lin Jin & Xin-Yang He. (2021) Statins: a repurposed drug to fight cancer. Journal of Experimental & Clinical Cancer Research 40:1.
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Ning An, Tao Yang, Xiao-Xia Zhang & Mei-xia Xu. (2021) Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB. Innate Immunity 27:7-8, pages 543-552.
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Opalina Vetrichelvan, Priyatham Gorjala, Oscar Goodman & Ranjana Mitra. (2021) Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis. PLOS ONE 16:9, pages e0257984.
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Amir R. Afshari, Hamid Mollazadeh, Neil C. Henney, Tannaz Jamialahmad & Amirhossein Sahebkar. (2021) Effects of statins on brain tumors: a review. Seminars in Cancer Biology 73, pages 116-133.
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Kasipandi Muniyandi, Blassan George, Thangaraj Parimelazhagan & Heidi Abrahamse. (2020) Role of Photoactive Phytocompounds in Photodynamic Therapy of Cancer. Molecules 25:18, pages 4102.
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Salman Ahmed, Haroon Khan, Michael Aschner, Hamed Mirzae, Esra Küpeli Akkol & Raffaele Capasso. (2020) Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects. International Journal of Molecular Sciences 21:16, pages 5622.
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Sandip A. Bandgar, Namdeo R. Jadhav & Arehalli S. Manjappa. (2020) A remarkable in vitro cytotoxic, cell cycle arresting and proapoptotic characteristics of low-dose mixed micellar simvastatin combined with alendronate sodium. Drug Delivery and Translational Research 10:4, pages 1122-1135.
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Jun Ma, Li-Na Han, Jian-Rui Song, Xiao-Ming Bai, Ju-Zi Wang, Li-Feng Meng, Jian Li, Wen Zhou, Yun Feng, Wei-Rong Feng, Jun-Jun Ma, Jun-Tao Hao & Zeng-Qiang Shen. (2020) Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation. Cellular Oncology 43:3, pages 377-394.
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Balázs Zoltán Zsidó, Mária Balog, Nikolett Erős, Miklós Poór, Violetta Mohos, Eszter Fliszár-Nyúl, Csaba Hetényi, Masaki Nagane, Kálmán Hideg, Tamás Kálai & Balázs Bognár. (2020) Synthesis of Spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity. International Journal of Molecular Sciences 21:2, pages 508.
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Huayao Li, Lijuan Liu, Jing Zhuang, Cun Liu, Chao Zhou, Jing Yang, Chundi Gao, Gongxi Liu & Changgang Sun. (2019) Identification of key candidate targets and pathways for the targeted treatment of leukemia stem cells of chronic myelogenous leukemia using bioinformatics analysis. Molecular Genetics & Genomic Medicine 7:9.
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Renato Bruni, Davide Barreca, Michele Protti, Virginia Brighenti, Laura Righetti, Lisa Anceschi, Laura Mercolini, Stefania Benvenuti, Giuseppe Gattuso & Federica Pellati. (2019) Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest. Molecules 24:11, pages 2163.
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Serena Fiorito, Francesco Epifano, Francesca Preziuso, Vito Alessandro Taddeo & Salvatore Genovese. 2019. Progress in the Chemistry of Organic Natural Products 108. Progress in the Chemistry of Organic Natural Products 108 143 205 .
Jeong-Hyeon Ko, Frank Arfuso, Gautam Sethi & Kwang Ahn. (2018) Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy. International Journal of Molecular Sciences 19:12, pages 4048.
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Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung & Kwang Seok Ahn. (2018) Bergamottin Inhibits Adipogenesis in 3T3-L1 Cells and Weight Regulation in Diet-Induced Obese Mice. The American Journal of Chinese Medicine 46:03, pages 601-615.
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Wenzheng Luo, Zhenyu Song, Hongwei Sun, Junxin Liang & Shanshan Zhao. (2017) Bergamottin, a natural furanocoumarin abundantly present in grapefruit juice, suppresses the invasiveness of human glioma cells via inactivation of Rac1 signaling. Oncology Letters.
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Wei-Lun Hung, Joon Hyuk Suh & Yu Wang. (2017) Chemistry and health effects of furanocoumarins in grapefruit. Journal of Food and Drug Analysis 25:1, pages 71-83.
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