Advanced search
Publication Cover
Pharmaceutical Biology Volume 54, 2016 - Issue 10
Submit an article Journal homepage
2,005
Views
31
CrossRef citations to date
0
Altmetric
Research Article

Trypanocidal and leishmanicidal activities of flavonoids isolated from Stevia satureiifolia var. satureiifolia

María Florencia BeerInstituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; ;Instituto de Tecnología Química (INTEQUI-CONICET), Universidad Nacional de San Luis, San Luis, Argentina;
,
Fernanda Maria FrankCátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina; ;Instituto de Microbiología y Parasitología Médica (IMPaM) (UBA-CONICET), Facultad de Medicina, Buenos Aires, Argentina;
,
Orlando Germán ElsoInstituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; ;Cátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina;
,
Augusto Ernesto BivonaCátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina; ;Instituto de Microbiología y Parasitología Médica (IMPaM) (UBA-CONICET), Facultad de Medicina, Buenos Aires, Argentina;
,
Natacha CernyCátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina; ;Instituto de Microbiología y Parasitología Médica (IMPaM) (UBA-CONICET), Facultad de Medicina, Buenos Aires, Argentina;
,
Gustavo GibertiInstituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina;
,
Emilio Luis MalchiodiCátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina; ;Instituto de Microbiología y Parasitología Médica (IMPaM) (UBA-CONICET), Facultad de Medicina, Buenos Aires, Argentina;
,
Virginia Susana MartinoInstituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; ;Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
,
María Rosario AlonsoInstituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina;
,
Valeria Patricia SülsenInstituto de Química y Metabolismo del Fármaco (IQUIMEFA) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina; ;Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, ArgentinaCorrespondence[email protected]
&
Silvia Ines CazorlaCátedra de Inmunología, Instituto de Estudios de la Inmunidad Humoral (IDEHU) (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina; ;Instituto de Microbiología y Parasitología Médica (IMPaM) (UBA-CONICET), Facultad de Medicina, Buenos Aires, Argentina; Correspondence[email protected]
 show all
Pages 2188-2195 | Received 01 Jul 2015, Accepted 01 Feb 2016, Published online: 17 Mar 2016

Citations (31)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Esther Della Nina Sahid, Josiane Clarice Claudino, Fernando Bombarda Oda, Flávio Alexandre Carvalho, André Gonzaga dos Santos, Marcia A. S. Graminha & Leandro da Costa Clementino. (2022) Baccharis trimera (Less.) DC leaf derivatives and eupatorin activities against Leishmania amazonensis. Natural Product Research 36:6, pages 1599-1603.
Read now

Articles from other publishers (30)

Erika Chriscensia, Alya Aqila Arham, Elizabeth Chrestella Wibowo, Lavisiony Gracius, Joshua Nathanael & Pietradewi Hartrianti. (2023) Eupatorin from Orthosiphon aristatus: A Review of The Botanical Origin, Pharmacological Effects and Isolation Methods. Current Bioactive Compounds 19:8.
Crossref
Neda Moradian, Gholamreza Hatam, Azadeh Hamedi & Ardalan Pasdaran. (2023) In vitro and in vivo antileishmanial activity of the hanging sedge flavonoids based on bio‐ guided fractionation assay. Chemical Biology & Drug Design 101:6, pages 1425-1434.
Crossref
Laura C. Laurella, Orlando G. Elso, Rachel Nápoles Rodriguez, Juan M. Viecenz, María Rosario Alonso, Esteban J. Bontempi, Emilio Malchiodi, Cesar A.N. Catalán, Silvia I. Cazorla & Valeria P. Sülsen. (2023) Antiprotozoal compounds from Mikania periplocifolia (Asteraceae). Fitoterapia 167, pages 105499.
Crossref
Nilanjana Majumder, Antara Banerjee & Samiran Saha. (2023) A review on new natural and synthetic anti-leishmanial chemotherapeutic agents and current perspective of treatment approaches.. Acta Tropica 240, pages 106846.
Crossref
Jimena Borgo, Orlando G. Elso, Jessica Gomez, Mauro Coll, Cesar A. N. Catalán, Juan Mucci, Guzmán Alvarez, Lía M. Randall, Patricia Barrera, Emilio L. Malchiodi, Augusto E. Bivona, María Florencia Martini & Valeria P. Sülsen. (2023) Anti-Trypanosoma cruzi Properties of Sesquiterpene Lactones Isolated from Stevia spp.: In Vitro and In Silico Studies. Pharmaceutics 15:2, pages 647.
Crossref
Jacqueline Soto-Sánchez. (2022) Bioactivity of Natural Polyphenols as Antiparasitic Agents and their Biochemical Targets. Mini-Reviews in Medicinal Chemistry 22:20, pages 2661-2677.
Crossref
Taoufiq Benali, Imane Jaouadi, Rokia Ghchime, Nasreddine El Omari, Kaoutar Harboul, Khalil Hammani, Maksim Rebezov, Mohammad Ali Shariati, Mohammad S. Mubarak, Jesus Simal-Gandara, Gokhan Zengin, Moon-Nyeo Park, Bonglee Kim, Shafi Mahmud, Learn-Han Lee & Abdelhakim Bouyahya. (2022) The Current State of Knowledge in Biological Properties of Cirsimaritin. Antioxidants 11:9, pages 1842.
Crossref
C. M. Albani, J. Borgo, J. Fabbri, P. Pensel, A. Paladini, M. F. Beer, L. Laurella, O. Elso, N. Farias, N. Elissondo, G. Gambino, V. Sülsen & M. C. Elissondo. (2022) Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-10.
Crossref
Dinesh Kumar Patel. (2022) Health Beneficial Aspect and Therapeutic Potential of Cirsimaritin in the Medicine for the Treatment of Human Health Complications. Current Bioactive Compounds 18:7.
Crossref
C. M. Albani, J. Borgo, J. Fabbri, P. Pensel, L. Fasciani, O. Elso, D. Papademetrio, D. Grasso, A. Paladini, M. F. Beer, N. E. Farias, N. Elissondo, G. Gambino, J. Zoppi, V. Sülsen & M. C. Elissondo. (2021) Anthelmintic activity of Stevia multiaristata extract against Echinococcus granulosus sensu stricto . Parasitology 149:4, pages 519-528.
Crossref
Daniel Pardo-Rodriguez, Paola Lasso, José Mateus, John Mendez, Concepción J. Puerta, Adriana Cuéllar, Jorge Robles & Claudia Cuervo. (2022) A terpenoid-rich extract from Clethra fimbriata exhibits anti-Trypanosoma cruzi activity and induces T cell cytokine production. Heliyon 8:3, pages e09182.
Crossref
Paola García-Huertas & Nora Cardona-Castro. (2021) Advances in the treatment of Chagas disease: Promising new drugs, plants and targets. Biomedicine & Pharmacotherapy 142, pages 112020.
Crossref
Jimena Borgo, Laura C. Laurella, Florencia Martini, Cesar A. N. Catalán & Valeria P. Sülsen. (2021) Stevia Genus: Phytochemistry and Biological Activities Update. Molecules 26:9, pages 2733.
Crossref
J. Sebastián Castañeda, María Suta-Velásquez, Jose Mateus, Daniel Pardo-Rodriguez, Concepción J. Puerta, Adriana Cuéllar, Jorge Robles & Claudia Cuervo. (2021) Preliminary chemical characterization of ethanolic extracts from Colombian plants with promising anti - Trypanosoma cruzi activity. Experimental Parasitology 223, pages 108079.
Crossref
María José Larrazábal-Fuentes, Carlos Fernández-Galleguillos, Jenifer Palma-Ramírez, Javier Romero-Parra, Kevin Sepúlveda, Alexandra Galetovic, Jorge González, Adrián Paredes, Jorge Bórquez, Mario J. Simirgiotis & Javier Echeverría. (2020) Chemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials of Artemisia copa Phil. (Asteraceae). Frontiers in Pharmacology 11.
Crossref
Ivica Dimkić, Marija Petrović, Milan Gavrilović, Uroš Gašić, Petar Ristivojević, Slaviša Stanković & Peđa Janaćković. (2020) New perspectives of purple starthistle (Centaurea calcitrapa) leaf extracts: phytochemical analysis, cytotoxicity and antimicrobial activity. AMB Express 10:1.
Crossref
Jian-Hua Xu, Yangming Martin Lo, Wen-Chang Chang, Da-Wei Huang, James Swi-Bea Wu, Yu-Yuan Jhang, Wen-Chung Huang, Chih-Yuan Ko & Szu-Chuan Shen. (2020) Identification of Bioactive Components from Ruellia tuberosa L. on Improving Glucose Uptake in TNF-α-Induced Insulin-Resistant Mouse FL83B Hepatocytes. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-7.
Crossref
Marina Themoteo Varela & João Paulo S. Fernandes. (2020) Natural Products: Key Prototypes to Drug Discovery Against Neglected Diseases Caused by Trypanosomatids. Current Medicinal Chemistry 27:13, pages 2133-2146.
Crossref
Ana Lidia Pérez-Castorena, Antonio Nieto-Camacho & Emma Maldonado. (2020) Sesquiterpene lactones and other constituents from Stevia jorullensis. Biochemical Systematics and Ecology 89, pages 104003.
Crossref
Zhiping Zhang, Yanzhi He & Xinyue Zhang. 2020. Pectins - Extraction, Purification, Characterization and Applications. Pectins - Extraction, Purification, Characterization and Applications.
Jessica K.T. Sousa, Luciana M.R. Antinarelli, Débora V.C. Mendonça, Daniela P. Lage, Grasiele S.V. Tavares, Daniel S. Dias, Patrícia A.F. Ribeiro, Fernanda Ludolf, Vinicio T.S. Coelho, João A. Oliveira-da-Silva, Luísa Perin, Bianka A. Oliveira, Denis F. Alvarenga, Miguel A. Chávez-Fumagalli, Geraldo C. Brandão, Vandack Nobre, Guilherme R. Pereira, Elaine S. Coimbra & Eduardo A.F. Coelho. (2019) A chloroquinoline derivate presents effective in vitro and in vivo antileishmanial activity against Leishmania species that cause tegumentary and visceral leishmaniasis. Parasitology International 73, pages 101966.
Crossref
Pone Kamdem Boniface & Elizabeth Igne Ferreira. (2019) Flavonoids as efficient scaffolds: Recent trends for malaria, leishmaniasis, Chagas disease, and dengue. Phytotherapy Research 33:10, pages 2473-2517.
Crossref
Federico Salsi, Gisele Bulhões Portapilla, Saskia Simon, Maximilian Roca Jungfer, Adelheid Hagenbach, Sérgio de Albuquerque & Ulrich Abram. (2019) Effect of Fluorination on the Structure and Anti- Trypanosoma cruzy Activity of Oxorhenium(V) Complexes with S , N , S -Tridentate Thiosemicarbazones and Benzoylthioureas. Synthesis and Structures of Technetium(V) Analogues . Inorganic Chemistry 58:15, pages 10129-10138.
Crossref
Kaio S. Gomes, Thais A. da Costa-Silva, Igor H. Oliveira, Andrea M. Aguilar, Diogo Oliveira-Silva, Miriam Uemi, Wender A. Silva, Lennine R. Melo, Carlos Kleber Z. Andrade, Andre G. Tempone, João L. Baldim & João Henrique G. Lago. (2019) Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis. Bioorganic & Medicinal Chemistry Letters 29:12, pages 1459-1462.
Crossref
Roberval Nascimento Moraes Neto, Ruth Flávia Barros Setúbal, Taciana Mirely Maciel Higino, Maria Carolina Accioly Brelaz-de-Castro, Luís Cláudio Nascimento da Silva & Amanda Silva dos Santos Aliança. (2019) Asteraceae Plants as Sources of Compounds Against Leishmaniasis and Chagas Disease. Frontiers in Pharmacology 10.
Crossref
A. L. Perez-Castorena, A. Arciniegas, A. Nieto-Camacho, J. L. Villasenor & A. Romo de V ivar. (2019) Chemical Constituents of Stevia subpubescens var. subpubescens and Evaluation of the Anti-Inflammatory Activity. Chemistry of Natural Compounds 55:3, pages 538-539.
Crossref
M. A. M. Salih, M. Fakiola, P. A. Lyons, B. M. Younis, A. M. Musa, A. M. Elhassan, D. Anderson, G. Syn, M. E. Ibrahim, J. M. Blackwell & H. S. Mohamed. (2017) Expression profiling of Sudanese visceral leishmaniasis patients pre- and post-treatment with sodium stibogluconate. Parasite Immunology 39:6, pages e12431.
Crossref
João Luiz Baldim, Bianca Gonçalves Vasconcelos de Alcântara, Olívia da Silva Domingos, Marisi Gomes Soares, Ivo Santana Caldas, Rômulo Dias Novaes, Tiago Branquinho Oliveira, João Henrique Ghilardi Lago & Daniela Aparecida Chagas-Paula. (2017) The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids. Oxidative Medicine and Cellular Longevity 2017, pages 1-12.
Crossref
Danielle Oliveira dos Anjos, Eliomara Sousa Sobral Alves, Vinicius Tomaz Gonçalves, Sheila Suarez Fontes, Mateus Lima Nogueira, Ana Márcia Suarez-Fontes, João Batista Neves da Costa, Fabricio Rios-Santos & Marcos André Vannier-Santos. (2016) Effects of a novel β–lapachone derivative on Trypanosoma cruzi : Parasite death involving apoptosis, autophagy and necrosis. International Journal for Parasitology: Drugs and Drug Resistance 6:3, pages 207-219.
Crossref
Daniel Pardo-Rodriguez, Paola Lasso, Jose Mateus, Jonh Jairo Mendez Arteaga, Concepción J. Puerta, Adriana Cuéllar, Jorge Robles & Claudia L. Cuervo. (2021) A Terpenoid-Rich Extract from <i>Clethra Fimbriata</i> Exhibits anti- <i>Trypanosoma cruzi</i> Activity and Induces T Cell Cytokine Production. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.