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Pharmaceutical Biology Volume 54, 2016 - Issue 10
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Research Article

Shengmai injection attenuates the cerebral ischemia/reperfusion induced autophagy via modulation of the AMPK, mTOR and JNK pathways

Haopeng YangJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
,
Long LiJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
,
Kecheng ZhouJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
,
Yuqing WangJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
,
Teng GuanJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
,
Chengzhi ChaiJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
,
Junping KouJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR ChinaCorrespondence[email protected]
,
Boyang YuJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
&
Yongqing YanJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, PR China
 show all
Pages 2288-2297 | Received 17 Jun 2015, Accepted 13 Feb 2016, Published online: 17 Mar 2016

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Narayana Pineda-Ramírez, Germán Fernando Gutiérrez Aguilar, Mónica Espinoza-Rojo & Penélope Aguilera. (2018) Current evidence for AMPK activation involvement on resveratrol-induced neuroprotection in cerebral ischemia. Nutritional Neuroscience 21:4, pages 229-247.
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Articles from other publishers (24)

Huanhuan Wang, Liying Tang, Shaowei Hu, Xixian Kong, Yi Ouyang, Dong Zhang, Yi Zhang, Shihuan Tang, Hongwei Wu & Hongjun Yang. (2024) Chemical profiling of Shengmai injection, tissue distribution and pharmacokinetic characteristics of ginsenosides after intravenous dosing Shengmai injection in rats with cerebral ischemia. Journal of Ethnopharmacology 319, pages 117119.
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Changchun Hei, Yujia Zhou, Chenyang Zhang, Furong Gao, Meiling Cao, Shilin Yuan, Yixin Qin, P. Andy Li & Xiao Yang. (2022) Rapamycin ameliorates brain damage and maintains mitochondrial dynamic balance in diabetic rats subjected to middle cerebral artery occlusion. Metabolic Brain Disease 38:2, pages 409-418.
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Marjan Talebi, Seyyed Ali Mohammadi Vadoud, Alireza Haratian, Mohsen Talebi, Tahereh Farkhondeh, Ali Mohammad Pourbagher-Shahri & Saeed Samarghandian. (2022) The interplay between oxidative stress and autophagy: focus on the development of neurological diseases. Behavioral and Brain Functions 18:1.
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Yi Ouyang, Liying Tang, Shaowei Hu, Guanghuan Tian, Caihong Dong, Huaqing Lai, Huanhuan Wang, Jie Zhao, Hongwei Wu, Fangbo Zhang & Hongjun Yang. (2022) Shengmai san-derived compound prescriptions: A review on chemical constituents, pharmacokinetic studies, quality control, and pharmacological properties. Phytomedicine 107, pages 154433.
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Qian Zhang, Meng Jia, YunFu Wang, Qun Wang & Jianping Wu. (2022) Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury. Neurochemical Research 47:12, pages 3525-3542.
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Min Wang & Ya Peng. (2022) Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke. Frontiers in Molecular Neuroscience 15.
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Tianchi Lan, Yangyang Xu, Shucui Li, Ning Li, Shuping Zhang & Haibo Zhu. (2022) Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway. BMC Pharmacology and Toxicology 23:1.
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Ke Song, Yikun Sun, Haoqi Liu, Yuanyuan Li, Na An, Liqin Wang, Hanlai Zhang, Fan Yang, Yanwei Xing & Yonghong Gao. (2022) Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of Ischaemic Stroke. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-17.
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Toushen Hong, Yang Zhou, Li Peng, Xiaoying Wu, Yixin Li, Yumei Li & Yong Zhao. (2022) Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia–Reperfusion Injury by Enhancing Mitophagy. Neuroscience 482, pages 30-42.
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Ping Huang, Haitong Wan, Chongyu Shao, Chang Li, Ling Zhang & Yu He. (2022) Recent Advances in Chinese Herbal Medicine for Cerebral Ischemic Reperfusion Injury. Frontiers in Pharmacology 12.
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Linjie Su, Yining Liu, Huifen Ma, Fan Zheng, Yujie Daia, Tiezheng Wang, Guangyun Wang, Fang Li, Yuanyuan Zhang, Boyang Yu, Shuaishuai Gong & Junping Kou. (2022) YiQiFuMai lyophilized injection attenuates cerebral ischemic injury with inhibition of neuronal autophagy through intervention in the NMMHC IIA–actin–ATG9A interaction. Phytomedicine 95, pages 153882.
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Lian Liu, Quan Cao, Wenwei Gao, Bing‐yu Li, Cheng Zeng, Zhongyuan Xia & Bo Zhao. (2021) Melatonin ameliorates cerebral ischemia‐reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1‐BMAL1 pathway. The FASEB Journal 35:12.
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Qi Chen, Ping Zhang, Qiu-Xia Xiao, Qing Liu & Ying Zhang. (2020) Protective effect of Shengmai injection on myocardial endothelial cell glycoprotein detachment after myocardial ischemia-reperfusion injury in isolated rat hearts. Perfusion 36:7, pages 757-765.
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Pengqian Wang, Yanan Yu, Jun Liu, Bing Li, Yingying Zhang, Dongfeng Li, Wenjuan Xu, Qiong Liu & Zhong Wang. (2021) IMCC: A Novel Quantitative Approach Revealing Variation of Global Modular Map and Local Inter-Module Coordination Among Differential Drug’s Targeted Cerebral Ischemic Networks. Frontiers in Pharmacology 12.
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Yangxin Li, Jiayi Sun, Ruixia Wu, Jinrong Bai, Ya Hou, Yong Zeng, Yi Zhang, Xiaobo Wang, Zhang Wang & Xianli Meng. (2020) Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition. Frontiers in Pharmacology 11.
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Guangyun Wang, Tiezheng Wang, Yuanyuan Zhang, Fang Li, Boyang Yu & Junping Kou. (2019) Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway. Molecules 24:19, pages 3624.
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Yi Zhang, Li-tian Ma, Jie Li, Yu Qiao, Jun-ye Liu, Jin Wang, Qin-you Ren, Jin-tao Hu & Jin Zheng. (2018) Anti-fibrotic Effects and Mechanism of Shengmai Injection (生脉注射液) on Human Hepatic Stellate Cells LX-2. Chinese Journal of Integrative Medicine 25:3, pages 197-202.
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Ya-Guang Huang, Wei Tao, Song-Bai Yang, Jin-Feng Wang, Zhi-Gang Mei & Zhi-Tao Feng. (2019) Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/ reperfusion injury. Neural Regeneration Research 14:6, pages 954.
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Dong Liu, Liqun Xu, Xiaoyan Zhang, Changhong Shi, Shubin Qiao, Zhiqiang Ma & Jiansong Yuan. (2019) Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury. Aging and disease 10:1, pages 116.
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Hae-Young Lopilly Park, Jie Hyun Kim & Chan Kee Park. (2018) Different contributions of autophagy to retinal ganglion cell death in the diabetic and glaucomatous retinas. Scientific Reports 8:1.
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Guang Yang, Ning Wang, Sai Wang Seto, Dennis Chang & Huangzheng Liang. (2018) Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: Involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway. Brain Research Bulletin 140, pages 243-257.
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Shuyu Zhan, Baoyue Ding, Yu-er Ruan, Xuan Huang, Guoqiang Liu, Xiaoqing Lv, Xiong Huang, Mingjuan Li, Ninghua Jiang & Qing Shao. (2018) A simple blood microdialysis in freely-moving rats for pharmacokinetic–pharmacodynamic modeling study of Shengmai injection with simultaneous determination of drug concentrations and efficacy levels in dialysate. Journal of Pharmaceutical and Biomedical Analysis 154, pages 23-30.
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Xiang Li, Qinhui Zhu, Yuanyuan Liu, Zhiyong Yang & Bin Li. (2018) Gastrodin protects myocardial cells against hypoxia/reoxygenation injury in neonatal rats by inhibiting cell autophagy through the activation of mTOR signals in PI3K-Akt pathway. Journal of Pharmacy and Pharmacology 70:2, pages 259-267.
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Zhi-gang Mei, Ling-jing Tan, Jin-feng Wang, Xiao-li Li, Wei-feng Huang & Hua-jun Zhou. (2017) Fermented Chinese formula Shuan-Tong-Ling attenuates ischemic stroke by inhibiting inflammation and apoptosis. Neural Regeneration Research 12:3, pages 425.
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