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Research Article

Toxicity of Withania Somnifera Root Extract in Rats and Mice

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Pages 205-212 | Accepted 19 May 1992, Published online: 27 Sep 2008

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Read on this site (6)

Pawan Kumar, Samudra P. Banik, Apurva Goel, Sanjoy Chakraborty, Manashi Bagchi & Debasis Bagchi. (2023) Revisiting the Multifaceted Therapeutic Potential of Withaferin A (WA), a Novel Steroidal Lactone, W-ferinAmax Ashwagandha, from Withania Somnifera (L) Dunal. Journal of the American Nutrition Association 0:0, pages 1-16.
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Deepa S. Mandlik (Ingawale)Ajay G. Namdeo. (2021) Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements 18:2, pages 183-226.
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Dharmendra K Yadav, Surendra Kumar, Saloni, Harpreet Singh, Mi-hyun Kim, Praveen Sharma, Sanjeev Misra & Feroz Khan. (2017) Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer. Drug Design, Development and Therapy 11, pages 1859-1870.
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Divya Singh, Rajiv Gupta & ShubhiniA. Saraf. (2012) Herbs–Are they Safe Enough? An Overview. Critical Reviews in Food Science and Nutrition 52:10, pages 876-898.
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Gita Rani, Saroj Arora & Avinash Nagpal. (2003) Direct Rhizogenesis from in vitro Leaves of Withania somnifera (L.) Dunal. Journal of Herbs, Spices & Medicinal Plants 10:3, pages 47-54.
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A. Chandrashekar Sharada, F. Emerson Solomon, Pathirisseri Uma Devi, Nayanabhirama Udupa & K. Kaitheri Srinivasan. (1996) Antitumor and Radiosensitizing Effects of Withaferin a on Mouse Ehrlich Ascites Carcinoma in vivo. Acta Oncologica 35:1, pages 95-100.
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Articles from other publishers (28)

Deepak Langade, Jayshree Dawane & Priti Dhande. (2023) Sub-acute toxicity of Ashwagandha (Withania somnifera) root extract in wistar rats. Toxicology Reports.
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Nosipho Fakudze, Paromita Sarbadhikary, Blassan George & Heidi Abrahamse. (2023) Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review. Pharmaceuticals 16:8, pages 1117.
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Christopher H. Fry, David Fluck & Thang S. Han. (2022) Adrenal hypofunction associated with ashwagandha (Withania somnifera) supplementation: a case report. Toxicology and Environmental Health Sciences 14:2, pages 141-145.
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Henok Kessete Afewerky, Hao Li, Tongmei Zhang, Xinyan Li, Yacoubou Abdoul Razak Mahaman, Limin Duan, Pengwei Qin, Jiequn Zheng, Lei Pei & Youming Lu. (2022) Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease. Scientific Reports 12:1.
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Henok Kessete Afewerky, Ayeni Emmanuel Ayodeji, Bashir Bolaji Tiamiyu, Joshua Iseoluwa Orege, Emmanuel Sunday Okeke, Aanuoluwapo Opeyemi Oyejobi, Petuel Ndip Ndip Bate & Sherif Babatunde Adeyemi. (2021) Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Bulletin of the National Research Centre 45:1.
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Subhabrata Paul, Shreya Chakraborty, Uttpal Anand, Swarnali Dey, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Manoj Tukaram Patil, Ramesh Kandimalla, Jarosław Proćków & Abhijit Dey. (2021) Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomedicine & Pharmacotherapy 143, pages 112175.
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Pulok K. Mukherjee, Subhadip Banerjee, Sayan Biswas, Bhaskar Das, Amit Kar & C.K. Katiyar. (2021) Withania somnifera (L.) Dunal - Modern perspectives of an ancient Rasayana from Ayurveda. Journal of Ethnopharmacology 264, pages 113157.
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N.P. Sibiya, E. Kayitesi & A. Moteetee. (2020) Mineral composition of selected indigenous wild southern African fruits. South African Journal of Botany 132, pages 87-94.
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Sultan Zahiruddin, Parakh Basist, Abida Parveen, Rabea Parveen, Washim Khan, Gaurav & Sayeed Ahmad. (2020) Ashwagandha in brain disorders: A review of recent developments. Journal of Ethnopharmacology 257, pages 112876.
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Neeraj Tandon & Satyapal Singh Yadav. (2020) Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. Journal of Ethnopharmacology 255, pages 112768.
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Hareram Birla, Chetan Keswani, Sachchida Nand Rai, Saumitra Sen Singh, Walia Zahra, Hagera Dilnashin, Aaina Singh Rathore & Surya Pratap Singh. (2019) Neuroprotective effects of Withania somnifera in BPA induced-cognitive dysfunction and oxidative stress in mice. Behavioral and Brain Functions 15:1.
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A.A. Ajao, N.P. Sibiya & A.N. Moteetee. (2019) Sexual prowess from nature: A systematic review of medicinal plants used as aphrodisiacs and sexual dysfunction in sub-Saharan Africa. South African Journal of Botany 122, pages 342-359.
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Muzamil Ahmad & Nawab J. Dar. 2017. Sustained Energy for Enhanced Human Functions and Activity. Sustained Energy for Enhanced Human Functions and Activity 137 154 .
Jasdeep Dhami, Edwin Chang & Sanjiv S. Gambhir. (2016) Withaferin A and its potential role in glioblastoma (GBM). Journal of Neuro-Oncology 131:2, pages 201-211.
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Anuradha Sehrawat, Suman K. Samanta, Su-Hyeong Kim, Eun-Ryeong Hahm & Shivendra V. Singh. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 175 196 .
Kallol Dutta, Vivek Swarup & Jean-Pierre Julien. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 389 415 .
Shruti B. Patel, Nirav J. Rao & Lal L. Hingorani. (2016) Safety assessment of Withania somnifera extract standardized for Withaferin A: Acute and sub-acute toxicity study. Journal of Ayurveda and Integrative Medicine 7:1, pages 30-37.
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Nawab John Dar, Abid Hamid & Muzamil Ahmad. (2015) Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cellular and Molecular Life Sciences 72:23, pages 4445-4460.
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Vikas Kumar, Amitabha Dey, Mallinath B. Hadimani, Tatjana Marcovic & Mila Emerald. (2015) Chemistry and pharmacology of withania somnifera: An update. TANG [HUMANITAS MEDICINE] 5:1, pages 1.1-1.13.
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Ruchi Tiwari, Sandip Chakrabort, Mani Saminathan, Kuldeep Dhama & Shoor Vir Singh. (2014) Ashwagandha (Withania somnifera): Role in Safeguarding Health, Immunomodulatory Effects, Combating Infections and Therapeutic Applications: A Review. Journal of Biological Sciences 14:2, pages 77-94.
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. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 353 961 .
Nadia Alam, Monzur Hossain, Md. Ibrahim Khalil, Mohammed Moniruzzaman, Siti Amrah Sulaiman & Siew Hua Gan. (2011) Recent advances in elucidating the biological properties of Withania somnifera and its potential role in health benefits. Phytochemistry Reviews 11:1, pages 97-112.
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Ya-ming Xu, Marilyn T. Marron, Emily Seddon, Steven P. McLaughlin, Dennis T. Ray, Luke Whitesell & A.A. Leslie Gunatilaka. (2009) 2,3-Dihydrowithaferin A-3β-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera. Bioorganic & Medicinal Chemistry 17:6, pages 2210-2214.
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. 2007. Veterinary Herbal Medicine. Veterinary Herbal Medicine 459 672 .
Haruyo Ichikawa, Yasunari Takada, Shishir Shishodia, Bolleddula Jayaprakasam, Muraleedharan G. Nair & Bharat B. Aggarwal. (2006) Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression. Molecular Cancer Therapeutics 5:6, pages 1434-1445.
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Ganesh Chandra Jagetia & Venkatasubbaiah Ashoka Kumar Venkatesha. (2005) Enhancement of Radiation Effect by <i>Aphanamixis polystachya</i> in Mice Transplanted with Ehrlich Ascites Carcinoma. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 28:1, pages 69-77.
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Ganesh Chandra Jagetia & Manjeshwar Shrinath Baliga. (2003) Treatment of mice with a herbal preparation (Mentat) protects against radiation‐induced mortality. Phytotherapy Research 17:8, pages 876-881.
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S. Banerjee, A. A. Naqvi, S. Mandal & P. S. Ahuja. (2006) Transformation of Withania somnifera (L) Dunal by Agrobacterium rhizogenes : Infectivity and phytochemical studies . Phytotherapy Research 8:8, pages 452-455.
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