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Original Article

Decreased Blood Loss After Cardiopulmonary Bypass using Heparin-Coated Circuit and 50% Reduction of Heparin Dose

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Pages 177-185 | Accepted 08 May 1992, Published online: 12 Jul 2009

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Read on this site (6)

Per Olsson, Javier Sanchez, Tom Eirik Mollnes & Johan Riesenfeld. (2000) On the blood compatibility of end-point immobilized heparin . Journal of Biomaterials Science, Polymer Edition 11:11, pages 1261-1273.
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Tor Ole Klemsdal. (1997) Transdermal Kinetics and Nitrate Tolerance. Measurements of Vasodilation by Photoplethysmography. Scandinavian Cardiovascular Journal 31:6, pages 369-369.
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Lars Bagge, Jan W. Borowiec, Stefan Thelin & Jan Hultman. (1997) Haemostasis at Low Heparin Dosage During Cardiopulmonary Bypass with Heparin-coated Circuits in Pigs. Scandinavian Cardiovascular Journal 31:5, pages 275-281.
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Jan W. Borowiec, Leif Hagman, Thomas H. Tötterman, Marcela Pekna, Per Venge & Stefan Thelin. (1995) Circulating Cytokines and Granulocyte-Derived Enzymes During Complex Heart Surgery: A Clinical Study with Special Reference to Heparin-Coating of Cardiopulmonary Bypass Circuits. Scandinavian Journal of Thoracic and Cardiovascular Surgery 29:4, pages 167-174.
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Mats Ernofsson, Stefan Thelin & Agneta Siegbahn. (1995) Thrombin Generation During Cardiopulmonary Bypass Using Heparin-Coated or Standard Circuits. Scandinavian Journal of Thoracic and Cardiovascular Surgery 29:4, pages 157-165.
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Marcela Pekna, Jan Borowiec, Magne K. Fagerhol, Per Venge & Stefan Thelin. (1994) Biocompatibility of Heparin-Coated Circuits Used in Cardiopulmonary Bypass. Scandinavian Journal of Thoracic and Cardiovascular Surgery 28:1, pages 5-11.
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Kalervo Werkkala, Janne J. Jokinen, Leena Soininen, Göran Dellgren, Stefan Hallhagen, Fredrik Sundberg, Jonas Andersson, Lars I. Dahms, Nadine Jurrmann & Simon Ersel. (2016) Clinical Durability of the CARMEDA BioActive Surface in EXCOR Ventricular Assist Device Pumps. ASAIO Journal 62:2, pages 139-142.
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Paul C. Begovac, Daniel Pond, Jennifer Recknor & Elisabeth Scholander. 2015. Drug-Device Combinations For Chronic Diseases. Drug-Device Combinations For Chronic Diseases 142 181 .
J. Nilsson, S. Scicluna, G. Malmkvist, L. Pierre, L. Algotsson, P. Paulsson, H. Bjursten & P. Johnsson. (2012) A randomized study of coronary artery bypass surgery performed with the Resting Heart  System utilizing a low vs a standard dosage of heparin. Interactive CardioVascular and Thoracic Surgery 15:5, pages 834-839.
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M. Ranucci. 2012. Minimized Cardiopulmonary Bypass Techniques and Technologies. Minimized Cardiopulmonary Bypass Techniques and Technologies 17 34 .
Marco Ranucci, Solomon Aronson, Wulf Dietrich, Cornelius M. Dyke, Axel Hofmann, Keyvan Karkouti, Marcel Levi, Gavin J. Murphy, Frank W. Sellke, Linda Shore-Lesserson & Christian von Heymann. (2011) Patient blood management during cardiac surgery: Do we have enough evidence for clinical practice?. The Journal of Thoracic and Cardiovascular Surgery 142:2, pages 249.e1-249.e32.
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Victor A. Ferraris, Jeremiah R. Brown, George J. Despotis, John W. Hammon, T. Brett Reece, Sibu P. Saha, Howard K. Song, Ellen R. Clough, Linda J. Shore-Lesserson, Lawrence T. Goodnough, C. David Mazer, Aryeh Shander, Mark Stafford-Smith, Jonathan Waters, Robert A. Baker, Timothy A. Dickinson, Daniel J. FitzGerald, Donald S. Likosky & Kenneth G. Shann. (2011) 2011 Update to The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines. The Annals of Thoracic Surgery 91:3, pages 944-982.
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Marco Ranucci, Anna Balduini, Antonio Ditta, Alessandra Boncilli & Simonetta Brozzi. (2009) A Systematic Review of Biocompatible Cardiopulmonary Bypass Circuits and Clinical Outcome. The Annals of Thoracic Surgery 87:4, pages 1311-1319.
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Theodore E. Warkentin & Andreas GreinacherDavid H. Lee & Theodore E. Warkentin. 2007. Heparin-Induced Thrombocytopenia. Heparin-Induced Thrombocytopenia 67 116 .
Ravi Taneja & Davy CH Cheng. (2006) Con: Heparin-Bonded Cardiopulmonary Bypass Circuits Should Be Routine for All Cardiac Surgical Procedures. Anesthesia & Analgesia 103:6, pages 1370-1372.
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Gregory A. Nuttall, William C. Oliver, David N. Fass, Whyte G. Owen, Devin Dinenno, Mark H. Ereth, Brent A. Williams, Joseph A. Dearani & Hartzell V. Schaff. (2006) A Prospective, Randomized Platelet-Function Study of Heparinized Oxygenators and Cardiotomy Suction. Journal of Cardiothoracic and Vascular Anesthesia 20:4, pages 554-561.
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Keisuke Ichinose, Taisuke Okamoto, Hironari Tanimoto, Atsushi Yoshitake, Masafumi Tashiro, Yuji Sakanashi, Katsuyuki Kuwana, Koichiro Tahara, Masahiro Kamiya & Hidenori Terasaki. (2004) Comparison of a New Heparin-coated Dense Membrane Lung with Nonheparin-coated Dense Membrane Lung for Prolonged Extracorporeal Lung Assist in Goats. Artificial Organs 28:11, pages 993-1001.
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Laurance Lequier. (2016) Extracorporeal Life Support in Pediatric and Neonatal Critical Care: A Review. Journal of Intensive Care Medicine 19:5, pages 243-258.
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Patrícia da Luz Moreira, Paula Rulf Marreco, Angela Maria Moraes, Maria Lúcia Furlan Wada & Selma Candelária Genari. (2003) Analysis of cellular morphology, adhesion, and proliferation on uncoated and differently coated PVC tubes used in extracorporeal circulation (ECC). Journal of Biomedical Materials Research Part B: Applied Biomaterials 69B:1, pages 38-45.
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William C. OliverJrJr. (2016) Overview of Heparin and Protamine Management and Dosing Regimens in Pediatric Cardiac Surgical Patients. Seminars in Cardiothoracic and Vascular Anesthesia 7:4, pages 387-410.
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Rena M. Cornelius, Javier Sanchez, Per Olsson & John L. Brash. (2003) Interactions of antithrombin and proteins in the plasma contact activation system with immobilized functional heparin. Journal of Biomedical Materials Research 67A:2, pages 475-483.
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Gabriel S. Aldea, Louise O. Soltow, Wayne L. Chandler, Christopher M. Triggs, Craig R. Vocelka, Gregory I. Crockett, Yong T. Shin, William E. Curtis & Edward D. Verrier. (2002) Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits. The Journal of Thoracic and Cardiovascular Surgery 123:4, pages 742-755.
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Javier Sánchez, Per Birger Lundquist, Graciela Elgue, Rolf Larsson & Per Olsson. (2002) Measuring the degree of plasma contact activation induced by artificial materials. Thrombosis Research 105:5, pages 407-412.
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M.E. Mukadam, P. Pritchard, D. Riddington, M. Wilkes, T.R. Graham, Jay Charles Horrow & Bruce D. Spiess. (2001) Case 7—2001 Management during cardiopulmonary bypass of patients with presumed fish allergy. Journal of Cardiothoracic and Vascular Anesthesia 15:4, pages 512-519.
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Staffan Svenmarker, Erik Sandström, Thomas Karlsson, Sören Häggmark, Erica Jansson, Micael Appelblad, Ronny Lindholm & Torkel Åberg. (2001) Neurological and general outcome in low-risk coronary artery bypass patients using heparin coated circuits. European Journal of Cardio-Thoracic Surgery 19:1, pages 47-53.
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Takayuki Nakajima, Kohei Kawazoe, Kazuyuki Ishibashi, Yoshimitsu Kubota, Tatsuya Sasaki, Hiroshi Izumoto & Tohru Nitatori. (2000) Reduction of heparin dose is not beneficial to platelet function. The Annals of Thoracic Surgery 70:1, pages 186-190.
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Patrícia Da Luz Moreira, Maria Lucia Furlan Wada & Waldyr P. Novello. (2001) Importance of Uniform Heparin Coating on Biopolymers. Artificial Organs 24:3, pages 209-211.
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Christian Olsson, Agneta Siegbahn, Eric Haldén, Bo Nilsson, Per Venge & Stefan Thelin. (2000) No benefit of reduced heparinization in thoracic aortic operation with heparin-coated bypass circuits. The Annals of Thoracic Surgery 69:3, pages 743-749.
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Arthur E. Baue. 2000. Multiple Organ Failure. Multiple Organ Failure 82 85 .
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Hans Peter Wendel, Hans-Joachim Schulze, Wolfgang Heller & Hans-Martin Hoffmeister. (1999) Platelet protection in coronary artery surgery: Benefits of heparin-coated circuits and high-dose aprotinin therapy. Journal of Cardiothoracic and Vascular Anesthesia 13:4, pages 388-392.
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George J. Despotis & J. Heinrich Joist. (1999) Anticoagulation and Anticoagulation Reversal With Cardiac Surgery Involving Cardiopulmonary Bypass: An Update. Journal of Cardiothoracic and Vascular Anesthesia 13:4, pages 18-29.
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Hans P WendelAlbertus M Scheule, Friedrich S Eckstein & Gerhard Ziemer. (2016) Haemocompatibility of paediatric membrane oxygenators with heparin-coated surfaces. Perfusion 14:1, pages 21-28.
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Rex L. Woolf & Monty G. Mythen. (1998) Con: heparin-bonded cardiopulmonary bypass circuits do not represent a desirable and cost-effective advance in cardiopulmonary bypass technology. Journal of Cardiothoracic and Vascular Anesthesia 12:6, pages 710-712.
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Linda Shore-Lesserson. (1998) Pro: heparin-bonded circuits represent a desirable option for cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia 12:6, pages 705-709.
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L.Henry EdmundsJrJr. (1998) Inflammatory response to cardiopulmonary bypass. The Annals of Thoracic Surgery 66:5, pages S12-S16.
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J. S�nchez, G. Elgue, J. Riesenfeld & P. Olsson. (1997) Inhibition of the plasma contact activation system of immobilized heparin: Relation to surface density of functional antithrombin binding sites. Journal of Biomedical Materials Research 37:1, pages 37-42.
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Sunao Watanabe, Kazuhide Hayashi, Hideki Yamanishi, Hideyuki Tomioka, Masaharu Minami, Noaki Shindoh & Kohji Miyamoto. (1997) Use of Percutaneous Cardiopulmonary Support System with Rotary Blood Pump in Graft Replacement of the Descending Thoracic and Thoracoabdominal Aorta. Artificial Organs 21:7, pages 846-851.
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Kiyofumi Morishita, Satomi Inoue, Toshio Baba, Jyun‐ichi Sakata, Teruhisa Kazui & Tomio Abe. (2008) Our Distal Aortic Perfusion System in Descending Thoracic and Thoracoabdominal Aortic Aneurysm Repairs. Artificial Organs 21:7, pages 822-824.
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