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Original Article

Pathophysiology and Mediators of Ischemia-Reperfusion Injury with Special Reference to Cardiac Surgery: A Review

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Pages 1-18 | Published online: 12 Jul 2009

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José García-de-la-Asunción, Ernesto Pastor, Jaime Perez-Griera, Francisco Javier Belda, Tania Moreno, Eva García-del-Olmo & Francisco Martí. (2013) Oxidative stress injury after on-pump cardiac surgery: Effects of aortic cross clamp time and type of surgery. Redox Report 18:5, pages 193-199.
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Guro Valen, Peter Sellei, Anders Öwall, Elsa Eriksson, Anders Kallner, Helge Waldum, Bo Risberg & Jarle Vaage. (1997) Release of Markers of Myocardial and Endothelial Injury Following Cold Cardioplegia Arrest in Pigs. Scandinavian Cardiovascular Journal 31:1, pages 45-50.
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Articles from other publishers (31)

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N Dhyani, B Saidullah, M Fahim & S Omanwar. (2019) Fenofibrate ameliorates neural, mechanical, chemical, and electrical alterations in the murine model of heart failure. Human & Experimental Toxicology 38:10, pages 1183-1194.
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Amir Ali Rahsepar, Asadollah Mirzaee, Fatemeh Moodi, Mohsen Moohebati, Shima Tavallaie, Fatemeh Khorashadizadeh, Behrooz Mottahedi, Jamil Esfehanizadeh, Ali Azari, Roshanak Khojasteh, Somayeh Mousavi, Roghayeh Paydar, Maral Amini, Majid Ghayour-Mobarhan, Gordon A. Ferns & Amirhossein Sahebkar. (2015) Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients. Medical Principles and Practice 24:5, pages 424-431.
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Walid Hamdy El-Tantawy. (2013) Biochemical effects of Solidago virgaurea extract on experimental cardiotoxicity. Journal of Physiology and Biochemistry 70:1, pages 33-42.
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Amir Ali Rahsepar, Asadollah Mirzaee, Fatemeh Moodi, Mohsen Moohebati, Shima Tavallaie, Fatemeh Khorashadizadeh, Ali Eshraghi, Maryam-Sadat Alavi, Laya Zarrabi, Mostafa Sajjadian, Maral Amini, Roshanak Khojasteh, Roghayeh Paydar, Somayeh Mousavi, Majid Ghayour-Mobarhan & Gordon A. Ferns. (2012) Changes in anti-heat shock protein 27 antibody and C-reactive protein levels following cardiac surgery and their association with cardiac function in patients with cardiovascular disease. Cell Stress and Chaperones 18:1, pages 65-74.
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Yasin Bayir, Zekai Halici, Emre Karakus, Abdulmecit Albayrak, Irmak Ferah, Esref Kabalar, Osman Keles, Mevlut Sait Keles & Bunyami Unal. (2012) Comparing Effects of Lacidipine, Ramipril, and Valsartan Against Experimentally Induced Myocardial Infarcted Rats. Cardiovascular Toxicology 12:2, pages 166-174.
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Wichert J. Kuijt, Judson Williams, Christopher B. Granger, Mitchell W. Krucoff & Matthew T. Roe. 2012. Management of Myocardial Reperfusion Injury. Management of Myocardial Reperfusion Injury 215 238 .
Andrea L. Tranquilli & Beatrice Landi. (2010) The origin of pre-eclampsia: From decidual “hyperoxia” to late hypoxia. Medical Hypotheses 75:1, pages 38-46.
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Song Zhang, Ben He, Junbo Ge, Changlin Zhai, Xin Liu & Pingang Liu. (2010) Characterization of chemical composition of Agaricus brasiliensis polysaccharides and its effect on myocardial SOD activity, MDA and caspase-3 level in ischemia–reperfusion rats. International Journal of Biological Macromolecules 46:3, pages 363-366.
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Roshan Tiwari, Mahalaxmi Mohan, Sanjay Kasture, Andrea Maxia & Mauro Ballero. (2009) Cardioprotective potential of myricetin in isoproterenol‐induced myocardial infarction in wistar rats. Phytotherapy Research 23:10, pages 1361-1366.
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Fengjiang Zhang, Gang Chen, Congcong Chen & Min Yan. (2009) Sevoflurane postconditioning converts persistent ventricular fibrillation into regular rhythm. European Journal of Anaesthesiology 26:9, pages 766-771.
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V.V. PADMA & C.S.S. DEVI. (2009) CARDIOPROTECTIVE EFFECT OF FISH OIL ON ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN RATS. Journal of Food Lipids 16:1, pages 19-32.
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Gino A. Kurian, M. Phil & Jose Paddikkala. (2008) Antioxidant status of South Indian patients undergoing coronary artery bypass graft surgery: A role of intra operative magnesium supplementation. International Journal of Cardiology 128:1, pages 139-141.
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Hairong Huang, Rong Yin, Jiaquan Zhu, Xiaomei Feng, Changtian Wang, Yi Sheng, Guohua Dong, Demin Li & Hua Jing. (2008) Exogenous melatonin ameliorates hepatic injury in a rat cardiopulmonary bypass model. European Journal of Pharmacology 580:3, pages 416-424.
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Hairong Huang, Rong Yin, Jiaquan Zhu, Xiaomei Feng, Changtian Wang, Yi Sheng, Guohua Dong, Demin Li & Hua Jing. (2007) Protective Effects of Melatonin and N-Acetylcysteine on Hepatic Injury in a Rat Cardiopulmonary Bypass Model. Journal of Surgical Research 142:1, pages 153-161.
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M. Rajadurai & P. Stanely Mainzen Prince. (2007) Preventive effect of naringin on isoproterenol-induced cardiotoxicity in Wistar rats: an in vivo and in vitro study. Toxicology 232:3, pages 216-225.
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M. Rajadurai & P. Stanely Mainzen Prince. (2007) Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. Toxicology 230:2-3, pages 178-188.
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Alessandra Bordoni, Cristina Angeloni, Emanuela Leoncini, Francesca Danesi, Magda Maranesi, Pier Luigi Biagi & Silvana Hrelia. (2005) Hypoxia/reoxygenation alters essential fatty acids metabolism in cultured rat cardiomyocytes: Protection by antioxidants. Nutrition, Metabolism and Cardiovascular Diseases 15:3, pages 166-173.
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Guro Valen, Anders Öwall, Shigeto Takeshima, Michel Goiny, Urban Ungerstedt & Jarle Vaage. (2004) Metabolic changes induced by ischemia and cardioplegia: a study employing cardiac microdialysis in pigs. European Journal of Cardio-Thoracic Surgery 25:1, pages 69-75.
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Marie-Christine Seghaye. (2005) The clinical implications of the systemic inflammatory reaction related to cardiac operations in children. Cardiology in the Young 13:3, pages 228-239.
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Julio J Ochoa, Maria J Vilchez, José Mataix, Susana Ibáñez-Quiles, Miguel A Palacios & Antonio Muñoz-Hoyos. (2003) Oxidative stress in patients undergoing cardiac surgery: comparative study of revascularization and valve replacement procedures. Journal of Surgical Research 111:2, pages 248-254.
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Guro Valen. (2003) The basic biology of apoptosis and its implications for cardiac function and viability. The Annals of Thoracic Surgery 75:2, pages S656-S660.
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Alessandra Bordoni, Silvana Hrelia, Cristina Angeloni, Emanuele Giordano, Carlo Guarnieri, Claudio M Caldarera & Pier L Biagi. (2002) Green tea protection of hypoxia/reoxygenation injury in cultured cardiac cells. The Journal of Nutritional Biochemistry 13:2, pages 103-111.
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G. Clermont, C. Vergely, C. de Girard & L. Rochette. (2002) Atteintes cellulaires associées à une circulation extracorporelle. Annales de Cardiologie et d'Angéiologie 51:1, pages 38-43.
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Guro Valen, Gabrielle Paulsson & Jarle Vaage. (2001) Induction of inflammatory mediators during reperfusion of the human heart. The Annals of Thoracic Surgery 71:1, pages 226-232.
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Jakob Vinten-Johansen & Gerald D. Buckberg. 2000. Nitric Oxide. Nitric Oxide 661 685 .
Ulrich Pantke, Thomas Volk, Martin Schmutzler, Wolfgang J. Kox, Nicolle Sitte & Tilman Grune. (1999) Oxidized proteins as a marker of oxidative stress during coronary heart surgery. Free Radical Biology and Medicine 27:9-10, pages 1080-1086.
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Andras Nagy, Guro Valen, Bengt Ek, Peter Sellei, Per-Ove Sjöquist & Jarle Vaage. (1998) Effects of a Novel, Low-Molecular Weight Inhibitor of Lipid Peroxidation on Ischemia–Reperfusion Injury in Isolated Rat Hearts and in Cultured Cardiomyocytes. Free Radical Biology and Medicine 24:9, pages 1462-1469.
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Guro Valen, Shigeto Takeshima & Jarle Vaage. (1996) Preconditioning improves cardiac function after global ischemia, but not after cold cardioplegia. The Annals of Thoracic Surgery 62:5, pages 1397-1403.
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Guro Valen, Olöf Sigurdardottir & Jarle Vaage. (1996) SYSTEMIC RELEASE OF THROMBOMODULIN, BUT NOT FROM THE CARDIOPLEGIC, REPERFUSED HEART DURING OPEN HEART SURGERY. Thrombosis Research 83:4, pages 321-328.
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Anders Winnerkvist, Björn Wiman, Guro Valen & Jarle Vaage. (1996) Release of tissue plasminogen activator during reperfusion after different times of ischaemia in isolated, perfused rat hearts. Thrombosis Research 82:6, pages 533-542.
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